TNF-α and IL-1 β Cytokine Gene Polymorphism in Patients with Nasal Polyposis

İsmi, Onur; Özcan, Cengiz; Polat, Gürbüz; Kül, Seval; Görür, Kemal; Puturgeli, Tugce

doi:10.5152/tao.2017.2389

Cited by 10 publications

(6 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…At the same time, a component of the inflammasome, GSDMD, is sheared and participates in the formation of cell membrane pores; the inflammatory mediators IL‐18 and Il‐1β can be released into the extracellular space through these pores 46 . As a result, pyroptosis can lead to an excessive inflammatory response, accumulation of inflammatory mediators and infiltration by inflammatory cells, finally leading to fever, low blood pressure and other clinical manifestations 47,48 …”

Section: Discussionmentioning

confidence: 99%

“…※P < .05, compared with the LPS + WT groupspace through these pores 46. As a result, pyroptosis can lead to an excessive inflammatory response, accumulation of inflammatory mediators and infiltration by inflammatory cells, finally leading to fever, low blood pressure and other clinical manifestations 47,48. As shown in the present study, CC-5013 ameliorated pathological damages to the liver and kidneys in the ALF and AKI mouse model.…”

mentioning

confidence: 99%

See 1 more Smart Citation

TNF‐α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury

et al. 2020

View full text Add to dashboard Cite

Acute liver failure (ALF) is a clinically common severe liver disease syndrome caused by various factors and could lead to serious disorders and decompensation of liver synthesis, detoxification, excretion and biotransformation. The main clinical manifestations of ALF are coagulopathy, jaundice, liver sexual encephalopathy and ascites. Supportive care and liver transplantation are the main treatment strategies for ALF 1 ; however, the mortality rate is still high. The kidneys are one of the most vulnerable extrahepatic organs in patients with liver failure. Acute kidney injury (AKI) is a group of clinical syndromes characterized by renal tubular injury, inflammation and vascular dysfunction. 2 AKI usually results in an increase in mortality in patients with liver failure. Therefore,

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

TNF‐α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury

et al. 2020

View full text Add to dashboard Cite

show abstract

“…These findings were partially in line with previous reports indicating that NKA expression or activity could be suppressed by SEB, LPS, IFN-γ, IL-1β, or TNF-α intervention on a variety of tissues and cells including rat intestinal mucosa [26], rat astrocytes [27], human intestinal xenografts [28], rat cardiac myocytes [29], and HepG2 cells (a human liver cancer cell line) [30], et al Previous studies have indicated the SEB and LPS could exacerbate inflammatory responses of HNECs in CRSwNP [31][32][33], thus, collectively, it can be surmised that NKA function in HNECs is impaired following SEB and LPS treatment, indicating that bacterial infection could trigger aggravation of inflammation via impairing NKA function in HNECs. In addition, type 1 IFN-γ, type 2 IFNs (IL-4 and IL-13), and IL-1β could also exert important roles in the inflammatory responses in CRSwNP [4,34,35]; therefore, it is reasonable to speculate that NKA function in HNECs is also impaired following type 1 IFN-γ, type 2 IFNs (IL-4 and IL-13), and IL-1β stimulation, indicating that these IFNs could also induce trigger inflammatory responses via impairing NKA function in HNECs.…”

Section: Discussionmentioning

confidence: 99%

The Expression and Regulation of Na+-K+-ATPase in Nasal Epithelial Cells of Chronic Rhinosinusitis with Nasal Polyps

Tang

Mao

et al. 2021

ORL

View full text Add to dashboard Cite

Objective: Na+-K+-ATPase (NKA) is essential in maintaining cell permeability, reserving potential energy, and preventing cellular edema. Nevertheless, how NKA expression is altered and regulated in chronic rhinosinusitis with nasal polyps (CRSwNPs) remain uncertain. Therefore, the present study aimed to explore the expression and regulation of NKA in CRSwNP. Methods: NKA immunolabeling was assessed by the immunohistochemistry method, NKA protein levels were detected with the Western blotting method, and mRNA levels of NKA and aquaporin-5 (AQP5) were assayed by real-time PCR in nasal tissues from CRSwNP and control subjects. The co-localization of NKA with inflammatory cells was evaluated by immunofluorescence staining. In addition, human nasal epithelial cells (HNECs) were cultured and stimulated using various stimulators to evaluate the regulation of NKA. Results: We found significantly decreased NKA positive cells, NKA protein levels, and mRNA levels of NKA and AQP5 in nasal tissues from CRSwNP patients compared to control subjects, especially in eosinophilic CRSwNP. Furthermore, NKA mRNA levels in HNECs were downregulated by staphylococcal enterotoxin B (SEB), lipopolysaccharides (LPSs), inflammatory cytokine (IFN)-γ, IL-4, IL-13, and IL-1β. Conclusion: NKA and AQP5 expressions were decreased in CRSwNP. NKA in HNECs could be suppressed by SEB, LPS, IFN-γ, IL-4, IL-13, and IL-1β. Impairment of NKA may contribute to the genesis and development of CRSwNP via inducing AQP5 downregulation and edema.

show abstract

“…It had been shown that cell pyroptosis is closely related to inflammatory response waterfall and organ damage caused by sepsis. Also, excessive activation induced by cell pyroptosis causes the release of a large amount of IL-1β, which would lead to cause inflammatory storms and organ damage once again (Ismi et al, 2017;Cavaillon, 2018). COX-2 is an inducible enzyme with enhanced the expression in tissue injury and inflammation.…”

Section: Figurementioning

confidence: 99%

The interaction of MD-2 with small molecules in huanglian jiedu decoction play a critical role in the treatment of sepsis

Chen

Wang²,

Liu³

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Huanglian Jiedu Decoction (HJD) is used for treating sepsis in China. Active components from HJD refer to various active ingredients of HJD, while active component formulation (ACF) refers to the combination of palmatine, berberine, baicalin, and geniposide from HJD according to the quantity of HJD. The detailed mechanisms of the active components from HJD and ACF in sepsis treatment are unclear. Molecular docking, surface plasmon resonance (SPR), ELISA, RT-qPCR, and Western blotting were used to assay the possible mechanism in vitro. The efficacy and mechanism of ACF and HJD were assessed by pharmacodynamics and metabolomics analyses, respectively. The results revealed that palmatine, berberine, baicalin, and geniposide showed good binding capacity to MD-2; decreased the release of NO, TNF-α, IL-6, and IL-1β; inhibited the mRNA expression of iNOS, TNF-α, IL-6, IL-1β, and COX-2; and downregulated the protein expressions of MD-2, MyD88, p-p65, and iNOS induced by LPS; which indicated that they can inactivate the LPS-TLR4/MD-2-NF-κB pathway. Thus, ACF was formed, and the pharmacodynamics assay suggested that ACF can reduce inflammatory cell infiltration and organ damage in accordance with HJD. Furthermore, 39 metabolites were selected and identified and the regulatory effect of these metabolites by ACF and HJD was almost consistent, but ACF might alleviate physical damage caused by HJD through regulating metabolites, such as 3-hydroxyanthranilic acid. ACF could represent HJD as a new formulation to treat sepsis.

show abstract

TNF-α and IL-1 β Cytokine Gene Polymorphism in Patients with Nasal Polyposis

Cited by 10 publications

References 31 publications

TNF‐α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury

TNF‐α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury

The Expression and Regulation of Na<sup>+</sup>-K<sup>+</sup>-ATPase in Nasal Epithelial Cells of Chronic Rhinosinusitis with Nasal Polyps

The interaction of MD-2 with small molecules in huanglian jiedu decoction play a critical role in the treatment of sepsis

Contact Info

Product

Resources

About