2008
DOI: 10.1016/j.neulet.2008.01.070
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TNF-α differentially modulates ion channels of nociceptive neurons

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Cited by 135 publications
(112 citation statements)
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“…Most research performed points towards reduction in ion current densities, e.g., for Na ϩ , Ca 2ϩ , and chloride conductances. For voltage-gated Na ϩ channels, a hyperpolarizing shift of inactivation curves is induced in chronic sepsis and steroid-denervation models of critical illness, thus reducing availability of Na This suggests a specific PKC-mediated change in Na ϩ channel gating through phosphorylation, probably between domains III and IV (45) by TNF-␣ in skeletal muscle, similar to what has been found in neurons (139). Whether TNF-␣ does so in muscle primarily by either the A 2 phospholipase, phospholipase C, or protein kinase A pathways or combination of those, all of which stimulate PKC (593), remains to be determined.…”
Section: Na V + -Channelsmentioning
confidence: 65%
“…Most research performed points towards reduction in ion current densities, e.g., for Na ϩ , Ca 2ϩ , and chloride conductances. For voltage-gated Na ϩ channels, a hyperpolarizing shift of inactivation curves is induced in chronic sepsis and steroid-denervation models of critical illness, thus reducing availability of Na This suggests a specific PKC-mediated change in Na ϩ channel gating through phosphorylation, probably between domains III and IV (45) by TNF-␣ in skeletal muscle, similar to what has been found in neurons (139). Whether TNF-␣ does so in muscle primarily by either the A 2 phospholipase, phospholipase C, or protein kinase A pathways or combination of those, all of which stimulate PKC (593), remains to be determined.…”
Section: Na V + -Channelsmentioning
confidence: 65%
“…Consequently, its longer-lasting receptors are considered to provide a more sensitive measure of TNFa 30 and other cytokine activity. 31,32 Although these and other cytokines can cause sensitization and hyperalgesia, [33][34][35] relationships between cytokine levels and CRPS severity have not been clearly demonstrated. Whereas 1 study found that higher levels of sTNF-RI in CRPS were correlated with mechanical hyperalgesia, 36 others found no correlations between the clinical symptoms of CRPS and the levels of TNFa 18,25 and IL-6.…”
mentioning
confidence: 99%
“…The rotarod test integrates motor and proprioceptive aspects of peripheral nerve function. There were no significant differences in performance ( TNF neutralizing antibody reduces peripheral nerve sensory function in pain models as well as in normal patients (27,28,(36)(37)(38), potentially through ion channels in nociceptive neurons (13). We directly assessed sensory function in response to thermal stimuli by using the hot plate test.…”
Section: Tnf Is a Network Hub In Peripheral Nerve Development That Linksmentioning
confidence: 99%
“…Patients receiving anti-TNF therapy experience nervous system pathologies (11). Although this has been largely attributed to the sequelae of an immune response, an alternative hypothesis is that nervous system tissues that use these molecules for communication are disrupted (12,13). Indeed, these hypotheses are not mutually exclusive.…”
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confidence: 99%