TNF-α is upregulated in T2DM patients with fracture and promotes the apoptosis of osteoblast cells in vitro in the presence of high glucose

The effect of experimental diabetes and glycaemic control on guided bone regeneration: histology and gene expression analyses

“…Therefore, our results indicated that a delayed and prolonged inflammatory response characterised the osseous wound healing events in the diabetic status, which is in accordance with evidence from Lee et al (2016), who have shown that experimental T1DM significantly increases the expression of pro-inflammatory cytokines during the regeneration of calvarial CSDs according to the GBR principle. Furthermore, our observations are in accordance with a recent clinical study demonstrating that pro-inflammatory cytokines and chemokines were upregulated in T2DM patients with bone fracture, as well as in osteoblasts subjected to high glucose stimulation (Sun et al 2016).…”

“…Furthermore, our observations are in accordance with a recent clinical study demonstrating that pro‐inflammatory cytokines and chemokines were upregulated in T2DM patients with bone fracture, as well as in osteoblasts subjected to high glucose stimulation (Sun et al. ).…”

Platelet-functionalized three-dimensional poly-ε-caprolactone fibrous scaffold prepared using centrifugal spinning for delivery of growth factors

“…Similarly, TNF-α was shown to inhibit the progress of bone healing by inducing osteoblast and chondrocyte apoptosis. 26,27 However, some reports show that some level of TNF-α signalizing is necessary for bone resorption during the repair process. 28 Thrombospondin is one of the most abundant platelet proteins.…”

Cytokine Regulation of Regenerative Processes in Pancreatic Gland in Alloxan-Induced Diabetic Rats, and It Correction by 1,3,4-Thiadiazine Composition and Lipoic Acid

“…Регуляция воспалитель-ных и аутоиммунных реакций иммунокомпе-тентными клетками осуществляется посредством секреции таких провоспалительных цитокинов, как фактор некроза опухолей-альфа (TNFα), ин-терлейкин-1 (IL-1) и интерлейкин-6 (IL-6) [17,35]. Согласно данным литературы, увеличение содержания TNFα в плазме крови наблюдается у пациентов с сахарным диабетом 1 и 2 типа [39,40], причем увеличение этого показателя корре-лирует с уровнем гипергликемии [18]. Отмечают повышенный уровень TNFα также у грызунов с аллоксановым и стрептозотоциновым диабетом [20].…”