TNF-α May Exert Different Antitumor Effects in Response to Radioactive Iodine Therapy in Papillary Thyroid Cancer with/without Autoimmune Thyroiditis

Gheorghe, Dan Cristian; Stanciu, Mihai; Zamfirescu, Anca; Stanciu, Adina Elena

doi:10.3390/cancers13143609

Cited by 7 publications

(5 citation statements)

References 29 publications

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“…Furthermore, the application of 131 I evokes thyroid cancer cell immobilization, which conforms to a previous study that found that the administration of 131 I represses thyroid cancer cell migration by modulating NIS expression and location (37). Moreover, the administration of 131 I upregulates the secretion of tumor necrosis factor-a (TNF-a) and its receptors TNFR1 and TNFR2 to initiate anti-tumor effects (38).…”

Section: Discussionsupporting

confidence: 87%

Poly (lactic-co-glycolic acid)-encapsulated iodine-131 nanoparticles fabricated with rhTSH induce apoptosis and immobilization of thyroid cancer cells

Fan

Xiong²,

Wang³

et al. 2023

Front. Oncol.

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BackgroundAggressive thyroid carcinoma (ATC) usually loses radioiodine avidity to iodine-131 (131I) due to the downregulation of sodium/iodide symporter (NIS). The expression of thyroid stimulating hormone receptor (TSHR) is more persistent than NIS and the administration of recombinant human thyroid stimulating hormone (rhTSH) promotes de novo NIS synthesis. Hence, exploring methods integrating 131I with rhTSH might be a feasible therapeutic strategy for selective delivery of 131I into thyroid cancer to fortify the effect of radioiodine ablation.MethodsThe 131I, poly (lactic-co-glycolic acid) (PLGA) and rhTSH were used to synthesize of the 131I-PLGA-rhTSH nanoparticles. The characteristics of the 131I-PLGA-rhTSH nanoparticles was determined using a light microscopy, scanning electron microscopy (SEM), autoradiography and immunofluorescence (IF) staining. The diameter of the 131I-PLGA-rhTSH nanoparticles was measured with a Mastersizer 3000, and the encapsulation efficiency (EF) of 131I in 131I-PLGA-rhTSH nanoparticles and the radioactivity of a single nanoparticle were determined. Then, the mouse tumor xenograft model was established, and the biodistribution and effect of 131I-PLGA-rhTSH nanoparticles on apoptosis of thyroid cance cells were investigated in vivo. Thereafter, the role of 131I-PLGA-rhTSH nanoparticles in cell viability using cell counting kit-8 and lactate dehydrogenase (LDH) release assays. Subsequently, the underlying mechanism of 131I-PLGA-rhTSH nanoparticles in reducing cell viability was assessed using immunostaining, boyden invasion assays and phalloidin staining.ResultsOur results showed that the method of developing nanoparticles-encapsulated 131I using poly (lactic-co-glycolic acid) (PLGA) and modified with rhTSH (131I-PLGA-rhTSH), was a feasible avenue for the integration of 131I and rhTSH. Meanwhile, the encapsulation efficiency (EF) of 131I-PLGA-rhTSH nanoparticles was approximately 60%, and the radioactivity of a single nanoparticle was about 1.1×10-2 Bq. Meanwhile, the 131I-PLGA-rhTSH nanoparticles were selectively delivered into, gradually enriched and slowly downregulated in xenograft tumor after the administration of 131I-PLGA-rhTSH nanoparticles through tail vein in mouse tumor xenograft model. Thereafter, the tumor weight was significantly reduced after the administration of 131I-PLGA-rhTSH nanoparticles. Subsequently, the application of 131I-PLGA-rhTSH nanoparticles facilitated apoptosis and attenuated immobilization via inhibiting F-actin assembling of FTC-133 cells.ConclusionThe present study develops a suitable approach integrating 131I and rhTSH, and this strategy is a feasible regimen enhancing the effect of radioiodine ablation for the treatment of thyroid cancer.

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Section: Discussionsupporting

confidence: 87%

Poly (lactic-co-glycolic acid)-encapsulated iodine-131 nanoparticles fabricated with rhTSH induce apoptosis and immobilization of thyroid cancer cells

Fan

Xiong²,

Wang³

et al. 2023

Front. Oncol.

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“…The presence of direct correlations between autoimmune thyroiditis and the presence of repairable and nonrepairable dislocations of one of the joints may be associated with the activation of MMP expression [25].…”

Section: Discussionmentioning

confidence: 99%

Correlation Between the State of the Temporomandibular Joint and Gynecological Status in Women of Reproductive Age

Novikov,

Korostashova,

Korovina

et al. 2023

Preprint

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Introduction The processes of synthesis and degradation of connective tissue are closely related to hormonal fluctuations occurring in the female body at various stages of development. Based on this, it can be assumed that the state of the cartilage and bone tissue of the components of the temporomandibular joint (TMJ) depends on the physiological state of the female body. The objective of this study is to establish correlations between the anamnestic data of gynecological health and the presence of pathologies of the temporomandibular joint in women of reproductive age. Methods For the study, 49 female patients of reproductive age with temporomandibular joint dysfunction (TMJD) were selected. Among the gynecological health history data, we selected the following parameters: hysterectomy, breast cancer, oophorectomy, number of deliveries, number of abortions, number of miscarriages, presence of thyroid gland cyst, presence of ovarian cyst, use of hormonal contraceptives, elevated prolactin level in the blood, hypothyroidism, autoimmune thyroiditis in the anamnesis, mastopathy, rheumatoid arthritis, and uterine fibromatosis. TMJ pathologies were differentiated by magnetic resonance imaging (MRI). The presence of correlation coefficients was checked using the Real Statistics 2019 extension for Microsoft Office Excel by calculating Kendall's tau (τ). Correlation ratios were considered statistically significant at p<0.05. Results Statistically significant correlations between pathologies of the temporomandibular joint and anamnestic data of gynecological status are observed only in relation to childbirth, abortions, ovarian cysts, uterine fibroids and pathologies of the thyroid gland, including hypothyroidism, and autoimmune thyroiditis. Conclusions The presence of the aforementioned pathologies in the anamnesis of a woman of reproductive age can serve as a basis for a detailed study of these processes and their impact on the condition of the temporomandibular joint.

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“…The association of DTC with T2DM has led to a change in the tumor microenvironment [25]. The tumor microenvironment confers ionizing radiation with either immunosuppressive or immune-stimulating properties [10,26]. There is still a lack of information on the role and functionality of immune cells after irradiation.…”

Section: Discussionmentioning

confidence: 99%

“…Blood cell interactions are essential in the pathophysiology of inflammation and immune responses in DTC patients [10]. These interactions have many facets, and it is often difficult to distinguish the specific roles of each cell type in response to high cumulative doses of 131 I.…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular Effects of Cumulative Doses of Radioiodine in Differentiated Thyroid Cancer Patients with Type 2 Diabetes Mellitus

Stanciu

Zamfirescu

et al. 2022

Cancers

Self Cite

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Radioiodine (131I) therapy for differentiated thyroid cancer (DTC) involves exposure of the whole body, including the heart, to ionizing radiation. This exposure to the subsequent risk of heart disease is uncertain, especially in patients with DTC associated with type 2 diabetes mellitus (DTC/+T2DM). The current study aimed to assess the relationship between left ventricular ejection fraction (LVEF), high cumulative 131I dose, and peripheral blood parameters in patients with DTC/−T2DM and DTC/+T2DM. The study enrolled 72 female patients with DTC/−T2DM and 24 with DTC/+T2DM who received cumulative 131I doses above 150 mCi (5.55 GBq). LVEF was lower in patients with concomitant T2DM than those without (p < 0.001). The cumulative 131I dosage was inversely correlated with LVEF only in DTC/−T2DM patients (r = −0.57, p < 0.001). In the DTC/+T2DM group, LVEF was negatively associated with absolute platelet count (r = −0.67, p < 0.001) and platelet-to-lymphocyte ratio (r = −0.76, p < 0.001). Our results demonstrate that exposure to high cumulative 131I doses has different cardiovascular effects in DTC/−T2DM and DTC/+T2DM.

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TNF-α May Exert Different Antitumor Effects in Response to Radioactive Iodine Therapy in Papillary Thyroid Cancer with/without Autoimmune Thyroiditis

Cited by 7 publications

References 29 publications

Poly (lactic-co-glycolic acid)-encapsulated iodine-131 nanoparticles fabricated with rhTSH induce apoptosis and immobilization of thyroid cancer cells

Poly (lactic-co-glycolic acid)-encapsulated iodine-131 nanoparticles fabricated with rhTSH induce apoptosis and immobilization of thyroid cancer cells

Correlation Between the State of the Temporomandibular Joint and Gynecological Status in Women of Reproductive Age

Cardiovascular Effects of Cumulative Doses of Radioiodine in Differentiated Thyroid Cancer Patients with Type 2 Diabetes Mellitus

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