TNF-α secretion and macrophage mortality induced by cobalt and chromium ions in vitro-Qualitative analysis of apoptosis

Catelas, Isabelle; Petit, Alain; Zukor, David J.; Antoniou, John; Huk, Olga L.

doi:10.1016/s0142-9612(02)00351-4

Cited by 129 publications

(116 citation statements)

References 47 publications

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“…28,29 Cytotoxic effects of cobalt ions have been demonstrated in macrophages, with cobalt ions inducing apoptosis, necrosis, and TNF-a secretion. [30][31][32][33][34] A similar cytotoxic effect has been observed in osteoblast-like cells, with reduced osteoblast proliferation, [35][36][37] viability, 35,37 and function 35,36,38 observed. In this study we investigated the in vitro effect of cobalt ions on primary human osteoblasts (pHOBs).…”

mentioning

confidence: 75%

Cobalt ions induce chemokine secretion in primary human osteoblasts

Queally¹,

Devitt²,

Butler³

et al. 2009

Journal Orthopaedic Research

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Chemokines are major regulators of the inflammatory response and have been shown to play an important role in periprosthetic osteolysis. Titanium particles have previously been shown to induce IL-8 and MCP-1 secretion in osteoblasts. These chemokines result in the chemotaxis and activation of neutrophils and macrophages, respectively. Despite a resurgence in the use of cobalt-chromium-molybdenum alloys in metal-on-metal arthroplasty, cobalt and chromium ion toxicity in the periprosthetic area has been insufficiently studied. In this study we investigate the in vitro effect of cobalt ions on primary human osteoblast activity. We demonstrate that cobalt ions rapidly induce the protein secretion of IL-8 and MCP-1 in primary human osteoblasts. This elevated chemokine secretion is preceded by an increase in the transcription of the corresponding chemokine gene. Using a Transwell migration chemotaxis assay we also demonstrate that the chemokines secreted are capable of inducing neutrophil and macrophage migration. Furthermore, cobalt ions significantly inhibit osteoblast function as demonstrated by reduced alkaline phosphatase activity and calcium deposition. In aggregate these data demonstrate that cobalt ions can activate transcription of the chemokine genes IL-8 and MCP-1 in primary human osteoblasts. Cobalt ions are not benign and may play an important role in the pathogenesis of osteolysis by suppressing osteoblast function and stimulating the production and secretion of chemokines that attract inflammatory and osteoclastic cells to the periprosthetic area. ß

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mentioning

confidence: 75%

Cobalt ions induce chemokine secretion in primary human osteoblasts

Queally¹,

Devitt²,

Butler³

et al. 2009

Journal Orthopaedic Research

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“…Co toxicity can affect many organs, and can cause various types of symptoms: neurological (tinnitus, vertigo, deafness, blindness, convulsions); cardiological (cardiomyopathy); haematological (polycythemia); and endocrine (hypothyroidism). Cr seems to be less cytotoxic but more genotoxic than Co (13,23). It induces tubular necrosis and interstitial cell damage which can result in impaired renal functioning (24).…”

Section: Systemic Effects Of Metal Ionsmentioning

confidence: 99%

The effects on bone cells of metal ions released from orthopaedic implants. A review

Sansone

Pagani

Melato

2013

CCMBM

168

182

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SummaryThe increasing use of orthopedic implants and, in particular, of hip and knee joint replacements for young and active patients, has stimulated interest and concern regarding the chronic, long-term effects of the materials used. This review focuses on the current knowledge of the adverse biologic reactions to metal particles released from orthopaedic implants in vivo and in vitro. More specifically, the purpose of this article is to provide an overview of the current literature about the adverse effects of metal particles on bone cells and peri-implant bone.

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“…TNF-α was chosen as a marker of cellular apoptotic activity. It was shown that both Co2+ and Cr3+ induce TNF-α secretion in a dose and time dependent manner (Catelas et al, 2003). Studies reported that human neuroblastoma cells treated with CdTe QD nanoparticles induced apoptosis associated with the increased Fas expression (Choi et al, 2007).…”

Section: J U S T a C C E P T E Dmentioning

confidence: 99%

Cadmium induces oxidative stress and apoptosis in lung epithelial cells

Kumar

Patil

et al. 2016

Toxicology Mechanisms and Methods

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Abstract:Cadmium (Cd) is one of the well-known highly toxic environmental and industrial pollutants.Cd first accumulates in the nucleus, and later interacts with zinc finger proteins of antiapoptotic genes; inhibit the binding of transcriptional factors and transcription. However, the role of Cd in oxidative stress and apoptosis is less understood. Hence the present study was undertaken to unveil the mechanism of action. A549 cells were treated with or without Cd

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TNF-α secretion and macrophage mortality induced by cobalt and chromium ions in vitro-Qualitative analysis of apoptosis

Cited by 129 publications

References 47 publications

Cobalt ions induce chemokine secretion in primary human osteoblasts

Cobalt ions induce chemokine secretion in primary human osteoblasts

The effects on bone cells of metal ions released from orthopaedic implants. A review

Cadmium induces oxidative stress and apoptosis in lung epithelial cells

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