TNFRSF11B: A potential plasma biomarker for diagnosis of obstructive sleep apnea

Wen, Wanwan; Ning, Yu; Zhang, Qing; Yang, Yunxiao; Jia, Yixin; Sun, Haili; Qin, Yanwen; Fang, Fang; Zhang, Ming; Wei, Yongxiang

doi:10.1016/j.cca.2018.12.017

Cited by 14 publications

(16 citation statements)

References 39 publications

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“…Drinkers were participants who consumed alcohol more than three days a week. Serum lipid, high-sensitivity C-reactive protein (hs-CRP), and other indicators were measured as previously described [ 22 , 23 ].…”

Section: Methodsmentioning

confidence: 99%

“…We quickly obtained fasting blood samples after the PSG examination. Procedures for plasma collection, processing, and storage have been previously described [ 22 , 23 ].…”

Section: Methodsmentioning

confidence: 99%

“…In the study, we custom-made a Luminex panel including CTSS to assess the impact of OSA in T2D (R&D Systems, Inc., Minneapolis, MN, USA). To ensure the accuracy and validity of the results, as previously described, we assessed the Luminex results by the intra-assay variability and standard curve [ 22 ]. In this study, the intra-assay coefficient of variation (CV%) of the standard curve was <4.0% (see Table S1 in the Supplementary Materials).…”

Section: Methodsmentioning

confidence: 99%

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Usefulness of Cathepsin S to Predict Risk for Obstructive Sleep Apnea among Patients with Type 2 Diabetes

et al. 2020

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Background. Obstructive sleep apnea (OSA) was highly prevalent in patients with type 2 diabetes (T2D). Cathepsin S (CTSS), a cysteine protease, is involved in the inflammatory activity in T2D and hypoxia conditions. The aim of the study was to evaluate whether CTSS could be involved in the inflammatory reaction of OSA in patients with T2D. Methods. We included 158 participants in this study matched for age, gender, and body mass index in 4 groups (control, non-OSA&T2D, OSA&non-T2D, and OSA&T2D). After overnight polysomnography, we collected the clinical data including anthropometrical characteristics, blood pressure, and fasting blood samples in the morning. Plasma CTSS concentration was evaluated using the human Magnetic Luminex Assay. Results. Compared with the control group, both the non-OSA&T2D group and the OSA&non-T2D group showed higher CTSS levels. Plasma CTSS expression was significantly increased in subjects with OSA&T2D compared to subjects with non-OSA&T2D. The OSA&T2D group had higher CTSS levels than the OSA&non-T2D group, but there were no statistically significant differences. Plasma CTSS levels showed significant correlation with the apnea-hypopnea index (AHI) (r=0.559, P<0.001) and plasma fasting blood glucose (r=0.427, P<0.001). After adjusting confounding factors, plasma CTSS levels were independently associated with the AHI (Beta: 0.386, 95% confidence intervals (CI): 21.988 to 57.781; P<0.001). Furthermore, we confirmed the higher pinpoint accuracy of plasma CTSS in the diagnosis of OSA (area under the curve: 0.868). Conclusions. Plasma CTSS expression was significantly elevated in the OSA&T2D group and was independently associated with the AHI; it could be a biomarker with a positive diagnostic value on diagnosing OSA among patients with T2D.

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Section: Methodsmentioning

confidence: 99%

“…We quickly obtained fasting blood samples after the PSG examination. Procedures for plasma collection, processing, and storage have been previously described [ 22 , 23 ].…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Usefulness of Cathepsin S to Predict Risk for Obstructive Sleep Apnea among Patients with Type 2 Diabetes

et al. 2020

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“…Plasm ESM-1 levels were quantitated by using a Human Magnetic Luminex Screening Assay (R&D Systems, Minneapolis, MN, USA). The concentrations of ESM-1 in plasm were determined according to the manufacturer’s instructions [17]. In order to determine the precision of the standards and cytokines levels values obtained by the Luminex platforms, coefficient of variation (CV%) was used to calculate intra-assay performance to determine the precision of results.…”

Section: Methodsmentioning

confidence: 99%

Circulating ESM-1 levels are correlated with the presence of coronary artery disease in patients with obstructive sleep apnea

Sun

Fang

et al. 2019

Respir Res

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Background Endothelial dysfunction is one of the most important early indicators of atherosclerosis in obstructive sleep apnea (OSA) patients. Endothelial cell specific molecules-1 (ESM-1), which is a novel endothelial dysfunction marker that may be linked to cardiovascular disease. We investigated to assess whether circulating ESM-1 levels are correlated with the presence of coronary artery disease (CAD) in patients with OSA. Methods We performed a cross-sectional study in 228 Chinese OSA subjects, including 185 patients with OSA and 43 controls. The Gensini stenosis scoring system was used to assess the severity of CAD. Circulating ESM-1 levels were measured by Human Magnetic Luminex Screening Assay. The associations between circulating ESM-1 levels and CAD were determined by multivariate logistic regression analysis. The association between ESM-1 levels and Gensini scores was determined by multivariate linear regression analysis. Results CAD patients had significantly higher circulating ESM-1 levels compared with non-CAD patients (1279.01[918.52–1770.71] pg/ml vs 585.46[423.61–812.56] pg/ml, P < 0.001). After adjusting for confounding factors, we found that circulating ESM-1 levels were an independent risk factor for CAD (OR = 1.633/100 pg ESM-1, 95%CI =1.179–2.262, P = 0.003), while circulating ESM-1 levels have no significant correlation with the Gensini score. Furthermore, circulating ESM-1 showed higher discriminatory accuracy in predicting the presence of OSA (AUC:0.910). Conclusions Circulating ESM-1 might function as a useful biomarker for monitoring the development and progression of CAD in OSA patients. Electronic supplementary material The online version of this article (10.1186/s12931-019-1143-6) contains supplementary material, which is available to authorized users.

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“…Fasting whole blood sample was collected after the PSG examination. Procedures for plasma collection, processing, and storage have been previously described [28].…”

Section: Collection and Storage Of Plasma Samplementioning

confidence: 99%

Plasma APRIL as a Potential Biomarker in the Diagnosis of Obstructive Sleep Apnea

Wen

Sun

Yang

et al. 2020

Preprint

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Background: Obstructive sleep apnea (OSA) is the most common type of sleep breathing disorder and is characterized by chronic intermittent hypoxia, which could cause inflammation and NF-KB-dependent inflammatory pathways activation. Circulating APRIL might play an important role in promoting inflammation and NF-KB-dependent inflammatory pathways activation. We explored the role of APRIL as a potential mechanism of inflammation in OSA patients. Methods: After detailed sleep evaluated, venous blood and demographic data were collected from 155 subjects with varying severity of OSA and 52 control subjects. Plasma levels of APRIL were measured by human Magnetic Luminex assay. Results: Plasma APRIL levels were significantly higher in OSA subjects compared with control subjects. Categorization of the OSA subjects into mild, moderate, and severe OSA subgroups showed that plasma levels of APRIL increased with severity. After adjusting confounding factors, found that increased plasma APRIL levels were conferred a higher odds ratio (OR) of OSA. Moreover, plasma APRIL levels were positively associated with the apnea-hypopnea index. Furthermore, plasma APRIL showed higher discriminatory accuracy in predicting the presence of OSA. Conclusions:Plasma APRIL levels were significantly associated with the occurrence of OSA and its severity. APRIL could be a plasma biomarker with a positive diagnostic value for inflammation and NF-KB–dependent inflammatory pathways activation in subjects with OSA.

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TNFRSF11B: A potential plasma biomarker for diagnosis of obstructive sleep apnea

Cited by 14 publications

References 39 publications

Usefulness of Cathepsin S to Predict Risk for Obstructive Sleep Apnea among Patients with Type 2 Diabetes

Usefulness of Cathepsin S to Predict Risk for Obstructive Sleep Apnea among Patients with Type 2 Diabetes

Circulating ESM-1 levels are correlated with the presence of coronary artery disease in patients with obstructive sleep apnea

Plasma APRIL as a Potential Biomarker in the Diagnosis of Obstructive Sleep Apnea

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