TNFRSF11B gene haplotype and its association with bone mineral density variations in postmenopausal Mexican-Mestizo women

Rojano-Mejía, David; Coral‐Vázquez, Ramón Mauricio; Espinosa, Leticia Cortes; Romero‐Hidalgo, Sandra; López-Medina, Guillermo; García, María del Carmen Aguirre; Coronel, Agustín; Ibarra, Roberto; Canto, Patricia

doi:10.1016/j.maturitas.2011.10.009

Cited by 7 publications

(12 citation statements)

References 35 publications

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“…This allele and GG genotype were not associated with BMD variations in postmenopausal Mexican-Mestizo women [37] corroborating data presented in this meta-analysis ( Table 2). Nevertheless the stratified evaluation in this polymorphism in mixed population showed data from only one study, so this result must be considered with caution.…”

Section: Discussionsupporting

confidence: 90%

Quantitative Assessment of the Association between Polymorphisms in Osteoprotegerin Gene and Risk of Low Bone Mineral Density

et al. 2015

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Background: Low bone mineral density (BMD) predisposes to os-teoporosis and elevated risk of fractures. Osteoprotegerin is a soluble molecule associated to metabolism of bone tissue with inhibition of osteoclast-differentiation. Several studies determined the relation among polymorphisms in osteoprotegerin gene and low BMD, but the results are contradictory, so an evaluation about these polymorphisms is necessary. This study carried out a meta-analysis to four polymor-phisms in osteoprotegerin gene (A163G, G1181C, T950C, T245G). Methods: A search in literature was made to identify studies with relevant information. The data was extracted by two investigators independently, following a standardized form. The statistical software Review Manager version 5.2 was used to calculation of heterogeneity (I²), Odds Ratio (OR) and Funnel plots with P<0.05. Results: Nineteen papers with twenty-one eligible studies with 5,120 patients and 4,386 controls were identified. G allele was associated to case group in A163G, G1181C and T245G polymorphisms (OR = 1.27, 95% CI 1.10, 1.46, P = 0.0010; OR = 1.25, 95% CI 1.14, 1.37, P < 0.00001; OR = 1.24, 95% CI 1.05, 1.48, P = 0.01, respectively). In T950C polymorphism, T allele neither C allele was associated to risk of bone low mineral density. No bias of publication was found in this analysis. Rerefences 1. Gnudi S, Sitta E, Fiumi N: Relationship between body composition and bone mineral density in women with and without osteoporosis: relative contribution of lean and fat mass. J Bone Miner Metab 2007, 25(5):326. 2. Jian WX, Long JR, Li MX, Liu XH, Deng HW: Genetic determination of variation and covariation of bone mineral density at the hip and spine in a Chinese population. J Bone Miner Metab 2005, 23(2):181-185. 3. Hussien YM, Shehata A, Karam RA, Alzahrani SS, Magdy H, El-Shafey AM: Polymorphism in vitamin D receptor and osteoprotegerin genes in Egyptian rheumatoid arthritis patients with and without osteoporosis. Mol Biol Rep 2013, 40:3675-3680. 4. Panach L, Mifsut D, Tarín JJ, Cano A, García-Pérez MÁ: Replication study of three functional polymorphisms associated with bone mineral density in a cohort of Spanish women. J Bone Miner Metab 2014, 32(6):691-698. 5. Horst-Sikorska W, Kalak R, Wawrzyniak A, Marcinkowska M, Celczynska-Bajew L, Slomski R: Association analysis of the polymorphisms of the VDR gene with bone mineral density and the occurrence of fractures. J Bone Miner Metab 2007, 25(5):310-319. 6. Yu F, Huang X, Miao J, Guo L, Tao D: Association between osteoprotegerin genetic variants and osteoporosis in Chinese postmenopausal women. Endocr J 2013, 60(12):1303-1307. 7. Nakashima T, Takayanagi H: Osteoclasts and the immune system. J Bone Miner Metab 2009, 27(5):519-529. 8. Wu ZZ, Liu M: The effect of low-body weight combined with T149C and A163G polymorphism of osteoprotegerin promoter region on osteoporosis. Chin J Geriatr 2006, 25:645-650. 9. Shui MM, Na SP, Xie RJ, Wang MG, Mu SH: Relationship between the polymorphisms of T149C and T950C in osteoprotegerin gene and the...

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Section: Discussionsupporting

confidence: 90%

Quantitative Assessment of the Association between Polymorphisms in Osteoprotegerin Gene and Risk of Low Bone Mineral Density

et al. 2015

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“…The frequency of risk alleles A and C of both polymorphisms (rs4355801 and rs6993813, respectively) was different from that described in other populations: 69% and 50.4% for European women (Richards et al, ; Styrkarsdottir et al, ), 76.6% and 66% for Asian women (Styrkarsdottir et al, ), 50% for Mexican‐Mestizo women (Rojano‐Mejía et al, ), and 36% and 39.8% for Maya‐Mestizo women (this study).…”

Section: Discussionmentioning

confidence: 62%

“…Styrkarsdottir et al () reported that rs4355801 and rs6993813 of TNFRSF11B were associated with low LS‐BMD in Korean and two Chinese Hong Kong populations. On the other hand, Rojano‐Mejía et al () did not find any association of the same polymorphisms with BMD variations in postmenopausal Mexican‐Mestizo women.…”

Section: Discussionmentioning

confidence: 91%

“…Likewise, several studies have examined the association between the p.K3N (rs2073618) polymorphism and osteoporosis in different ethnic groups (Rojano‐Mejía et al, ; Zhao et al, ). In contrast to Caucasian populations where the CC genotype (Asn/Asn) was the most frequent and is associated with an increase of BMD at the LS (Langdahl et al, ; Zhao et al, ), in our population we observed a low frequency of this genotype (13.5%) and no association with BMD variations.…”

Section: Discussionmentioning

confidence: 99%

“…Because of the fact that important ethnic differences have been observed in BMD variations (Leslie, ; Morton et al, ; Rojano‐Mejía et al, ) and that the Amerindian‐Mestizo population of México are genetically heterogeneous (Juárez‐Velázquez et al, ), the principal aim of this study was to analyze the possible association among one polymorphism of LRP5 and three polymorphisms of TNFRSF11B (as well their haplotypes) with BMD variations in one Amerindian‐Mestizo population from México, Maya.…”

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confidence: 99%

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Polymorphism of LRP5, but not of TNFRSF11B, is associated with a decrease in bone mineral density in postmenopausal maya‐mestizo women

Canto-Cetina

Reyes

Herrera

et al. 2013

American J Hum Biol

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Relation of the estrogen receptor and vitamin D receptor polymorphisms with bone mineral density in postmenopausal Mexican-mestizo women

Rojano-Mejía¹,

Coral‐Vázquez²,

Coronel³

et al. 2014

Gene

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TNFRSF11B gene haplotype and its association with bone mineral density variations in postmenopausal Mexican-Mestizo women

Cited by 7 publications

References 35 publications

Quantitative Assessment of the Association between Polymorphisms in Osteoprotegerin Gene and Risk of Low Bone Mineral Density

Quantitative Assessment of the Association between Polymorphisms in Osteoprotegerin Gene and Risk of Low Bone Mineral Density

Polymorphism of LRP5, but not of TNFRSF11B, is associated with a decrease in bone mineral density in postmenopausal maya‐mestizo women

Relation of the estrogen receptor and vitamin D receptor polymorphisms with bone mineral density in postmenopausal Mexican-mestizo women

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