To Analyze the Efficacy of Platelet-rich Plasma in Contrast to Platelet-rich Fibrin along with Synthetic Nanocrystalline Hydroxyapatite and β-tricalcium Phosphate Bone Graft in Regeneration of Bony Defects in Children

Sharma, Anshul; Saha, Sonali; Rai, Amit; Dhinsa, Kavita; Shadap, Nonie Marianne Koksi Sangma; Yadav, Gunjan

doi:10.5005/jp-journals-10005-2710

International Journal of Clinical Pediatric Dentistry

2024

DOI: 10.5005/jp-journals-10005-2710

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To Analyze the Efficacy of Platelet-rich Plasma in Contrast to Platelet-rich Fibrin along with Synthetic Nanocrystalline Hydroxyapatite and β-tricalcium Phosphate Bone Graft in Regeneration of Bony Defects in Children

Anshul Sharma,

Sonali Saha,

Amit Rai

et al.

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2024

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Release kinetics of growth factors loaded into β-TCP ceramics in an in vitro model

Waldmann,

Bohner,

Baghnavi

et al. 2024

Front. Bioeng. Biotechnol.

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Introductionβ-TCP ceramics are bone replacement materials that have recently been tested as a drug delivery system that can potentially be applied to endogenous substances like growth factors found in blood platelets to facilitate positive attributes.MethodsIn this work, we used flow chamber loading to load β-TCP dowels with blood suspensions of platelet-rich plasma (PRP), platelet-poor plasma (PPP), or buffy coat (BC) character. PRP and BC platelet counts were adjusted to the same level by dilution. Concentrations of TGF-β1, PDGF-AB, and IGF-1 from dowel-surrounding culture medium were subsequently determined using ELISA over 5 days. The influence of alginate was additionally tested to modify the release.ResultsConcentrations of TGF-β1 and PDGF-AB increased and conclusively showed a release from platelets in PRP and BC compared to PPP. The alginate coating reduced the PDGF-AB release but did not reduce TGF-β1 and instead even increased TGF-β1 in the BC samples. IGF-1 concentrations were highest in PPP, suggesting circulating levels rather than platelet release as the driving factor. Alginate samples tended to have lower IGF-1 concentrations, but the difference was not shown to be significant.DiscussionThe release of growth factors from different blood suspensions was successfully demonstrated for β-TCP as a drug delivery system with release patterns that correspond to PRP activation after Ca2+-triggered activation. The release pattern was partially modified by alginate coating.

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Release kinetics of growth factors loaded into β-TCP ceramics in an in vitro model

Waldmann,

Bohner,

Baghnavi

et al. 2024

Front. Bioeng. Biotechnol.

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show abstract

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To Analyze the Efficacy of Platelet-rich Plasma in Contrast to Platelet-rich Fibrin along with Synthetic Nanocrystalline Hydroxyapatite and β-tricalcium Phosphate Bone Graft in Regeneration of Bony Defects in Children

Cited by 1 publication

References 35 publications

Release kinetics of growth factors loaded into β-TCP ceramics in an in vitro model

Release kinetics of growth factors loaded into β-TCP ceramics in an in vitro model

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