To Assess the Culture Proven Neonatal Sepsis at a Tertiary Care Centre: An Institutional Based Study

Abstract

Background: Organisms causing neonatal sepsis vary in different regions and also change with time in the same area. The aim of this study was to evaluate the epidemiology of culture-proven neonatal sepsis. Material & Methods: This was a retrospective descriptive study conducted in the neonatal unit of Gujrat Adani Institute of Medical sciences, Bhuj, Gujrat. It consisted of patients with a positive blood culture during the study period. The clinical data of patients with culture-proven neonatal sepsis were reviewed. Patients with bacteraemia but with no other features suggestive of sepsis or those with organisms considered as contaminants were excluded. Infants who were in the neonatal unit beyond 28 days of life were also excluded from the study. Results: Our study showed that the there was no statistically significant differences in the sex, place of birth and mode of delivery between cases of EOS and LOS. There were 213 microorganisms isolated on blood culture of 150 patients with culture proven NNS during the study period. Of the 213 microorganisms¸ gram negative organisms were the most commonly isolated organisms in cases of culture-proven NNS [105 (49.29%)]. Conclusion:We concluded that Gram-negative microorganisms comprised the majority of the neonatal sepsis, with ESBL Klebsiella pneumoniae and A. baumannii being the most prevalent.