To assess the effectiveness of a chlorhexidine chip in the treatment of chronic periodontitis: A clinical and radiographic study

Abstract

Context:Controlled local delivery of disinfecting agents has been demonstrated to be efficient in improving the outcome of periodontal therapy.Aims:The aim of the present study was to evaluate the efficacy of a controlled-release biodegradable chlorhexidine chip (Periocol CG) when used as an adjunct to scaling and root planing in the treatment of periodontitis.Settings and Design:The study was carried out as randomized controlled two-group parallel clinical trial.Materials and Methods:Forty patients in the age group of 30-65 years suffering from mild to moderate chronic periodontitis, having pocket depth ranging between 5 and 8 mm, were selected for the study. At the screening visit, complete history taking, periodontal examination and full-mouth supragingival scaling was carried out for each patient. At the baseline visit (on the 7th day), all clinical parameters and radiographic parameters were recorded at selected sites and patients were randomly assigned to either the control group (group A) or the treatment group (group B). All patients in both the groups received complete subgingival scaling and root planing. Then, in group B, chlorhexidine chip (Periocol CG) was inserted at the selected site. Patients were recalled at 1 month, 2 months and 3 months from the baseline for recording clinical observations, and radiographic parameters were recorded at the end of the study.Statistical Analysis:Mean, standard deviation, Chi-square test, “t” test for equality of means and paired samples correlations were used.Results:There was a statistically significant clinical attachment gain, reduction in bleeding index scores, probing pocket depth reduction and bone gain in both the groups, but group B showed better results than group A, and these differences were statistically significant.Conclusions:The results of this study show that chlorhexidine chip (PerioCol-CG) is an effective adjunctive therapy to scaling and root planing in the treatment of chronic periodontitis.

Adjunctive Effects of A Piscean Collagen-Based Controlled-Release Chlorhexidine Chip in the Treatment of Chronic Periodontitis: A Clinical and Microbiological Study

“…The novelty and utility of this agent warrants further research. These clinical trials have attested the safety and non-toxicity of the product reporting no serious adverse effects [17][18][19][20]. The clinical efficacy of this chip in reducing probing depth, bleeding on probing and clinical attachment loss has been reported [18][19][20][21].…”

“…The drug delivery agent used here is a small orange-brown rectangular chip which contains approximately 2.5mg of chlorhexidine in a biodegradable matrix of fish collagen type I derived from the air bladder of fresh water fishes [16,17]. If needed the chip was trimmed with a scalpel.…”

Management of Chronic Periodontitis Using Chlorhexidine Chip and Diode Laser-A Clinical Study

“…Controlled delivery system has duration of drug release more than 24 hours. The effects of locally delivered controlled-release chlorhexidine have been shown to be evident upto 11weeks [25] [12,[26][27][28][29].…”

Local Drug Delivery in the Treatment of Periodontitis: A Review.

“…Perio chip releases chlorhexidine in vitro in a biphasic manner, initially releasing approximately 40% of the chlorhexidine within the first 24 hours, and then releasing the remaining chlorhexidine in an almost linear fashion for 7-10 days. Grover et al reported that chlorhexidine chip and SRP resulted in a clinically significant improvement in PPD and CAL compared with SRP alone 26 . Jagadish Pai et al showed that Clinically significant reduction in PPD, BOP and CAL by using chlorhexidine varnish and chlorhexidine chip along with SRP but the results were not statistically significant when compared with SRP alone 27 .…”