To compare the effect of sea buckthorn and silver sulfadiazine dressing on period of wound healing in patients with second‐degree burns: A randomized triple‐blind clinical trial

Abstract

Burn injuries can be associated with the incidence of disability and death, yet their management remains a costly difficult problem. We conducted this clinical trial to evaluate the period of wound healing with sea buckthorn dressings for the seconddegree burns and compare the results with 1% silver sulfadiazine (SSD) dressings. This randomized triple-blind clinical trial was conducted in a hospital in Isfahan, Iran.Fifty-five patients suffering second-degree burns were recruited through convenient sampling and randomly divided into two groups and treated with either sea buckthorn cream or 1% SSD. Wound dressings were done until complete wound healing was attained. The process of healing burns was monitored using the Bates-Jensen Wound Assessment Tool; complete healing was determined by using the standard burn healing checklist. It was deduced that the period of healing second-degree burns in the group treated with sea buckthorn cream was shorter than the group treated with 1% SSD (p < 0.001). The results demonstrated the greater clinical efficacy of sea buckthorn cream over 1% SSD for healing second-degree burns. It was concluded that using sea buckthorn dressing by reducing the period of wound healing can shorten the course of treatment of second-degree burns as well as reduce the burden of care in health care services.

The Potential of Medicinal Plants and Natural Products in the Treatment of Burns and Sunburn—A Review

“…In a randomised, triple-blind clinical trial, the effectiveness of sea buckthorn cream and 1% SSD cream in treating burns was investigated and compared [ 28 ]. The study involved 30 patients with second-degree thermal burns that affected no more than 10% of their total body surface area and occurred within 6 hours of arrival at the hospital.…”

Phytochemistry, health benefits, and food applications of sea buckthorn (Hippophae rhamnoides L.): A comprehensive review

“…Moreover, a randomized triple-blind clinical trial demonstrated that the healing period for second-degree burns in patients treated with 40% sea buckthorn cream was about 5 days shorter than for patients treated with 1% silver sulfadiazine dressings. The sea buckthorn cream had better clinical efficacy and shortened the healing time for second-degree burns ( 74 ). It was found that sea buckthorn seed oil promoted wound contraction by increasing hydroxyproline, hexosamine, DNA, and total protein content, which in turn promoted full-layer burn wound healing.…”

Phytochemistry and pharmacology of sea buckthorn (Elaeagnus rhamnoides; syn. Hippophae rhamnoides): progress from 2010 to 2021

“…Sea buckthorn (especially the oils) is well known for its wound and burn-healing properties. Abdullahzadeh and Shafiee ( 2021 ) compared the effectiveness of a cream containing 40% of “the active ingredient of sea buckthorn” fruit in treatment of second-degree burns, with that of a 1% silver sulfadiazine (SSD, a topical medicine commonly used for treatment of burns) cream. A randomized triple-blind clinical trial comprised 55 hospital patients.…”