To Correlate the Association of Markers of Chronic Renal Failure in Patients With and without Haemodialysis

Abstract

Abstract:Chronic kidney disease is a worldwide public health problem with an increasing incidence and prevalence, poor outcomes, and high cost. Outcomes of chronic kidney disease include not only kidney failure but also complications of decreased kidney function and cardiovascular disease. Current evidence suggests that some of these adverse outcomes can be prevented or delayed by early detection and by haemodialysis. The aim is to study and correlate the markers of chronic renal failure in patients undergoing with haemodialysis and without haemodialysis. The study consist of total 35 subjects as healthy controls, 35 as chronic renal failure without haemodialysis and 35 as chronic renal failures undergoing haemodialysis from last 5 months and more. Biochemical parameters studied were serum total cholesterol, triglyceride, urea, creatinine, Na + and K + . In the studied parameters, serum triglycerides, urea, creatinine, potassium were found to be significantly (p<0.01) increased in CRF without haemodialysis, but after haemodialysis these parameters were found to be normal except serum triglycerides, which was increased even after haemodialysis. No significant difference was seen in total cholesterol and sodium levels in studied groups (p>0.05). Chronic renal disease is accompanied by characteristic abnormalities of lipid metabolism, which appear as a consequence of nephrotic syndrome or renal insufficiency and are reflected in an altered urea, creatinine and potassium as well as elevated plasma triglyceride levels. Thus there is a correlation between the progression of renal disease and dyslipidemia. High triglyceride serum levels have been demonstrated to be independent risk factors for progression of renal disease in humans.