2016
DOI: 10.1111/febs.13712
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To deliver or to degrade – an interplay of the ubiquitin–proteasome system, autophagy and vesicular transport in plants

Abstract: The efficient utilization and subsequent reuse of cell components is a key factor in determining the proper growth and functioning of all cells under both optimum and stress conditions. The process of intracellular and intercellular recycling is especially important for the appropriate control of cellular metabolism and nutrient management in immobile organisms, such as plants. Therefore, the accurate recycling of amino acids, lipids, carbohydrates or micro-and macronutrients available in the plant cell become… Show more

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Cited by 41 publications
(38 citation statements)
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References 195 publications
(254 reference statements)
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“…ATG18g (hub #20) was the most highly connected autophagy hub followed by APG9 (hub # 122). Autophagy is an important part of the senescence process [54, 55]. …”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…ATG18g (hub #20) was the most highly connected autophagy hub followed by APG9 (hub # 122). Autophagy is an important part of the senescence process [54, 55]. …”
Section: Resultsmentioning
confidence: 99%
“…The most highly connected hub for autophagy was the ATG18g transcript in the turquoise module (hub #20; Additional file 11). Autophagy is a degradative process that involves the formation of autophagosomes [54] and intracellular vesicle transport [55]. ATG18g , APG9 ( ATG9 ) and ATG2 , all hubs in the turquoise module, are part of the ATG9 cycling system, which participates in the formation of autophagosomes [54].…”
Section: Discussionmentioning
confidence: 99%
“…The covalent modification of a protein by ubiquitin, or ubiquitination, modulates responses to ever-changing environmental conditions as well as numerous aspects of plant development. This type of post-translational modification is associated with all three major protein degradation pathways-the proteasome, the vacuole/lysosome, and the autophagosome-where it helps control the half-life of proteins (Clague and Urbe, 2010;Zientara-Rytter and Sirko, 2016), but also affects localization, activity, and interactions of many proteins (Komander and Rape, 2012). Ubiquitin conjugation is extraordinarily complex in plants, with more than 1500 ubiquitin-protein ligases actively participating in this process (Hua and Vierstra, 2011).…”
Section: Introductionmentioning
confidence: 99%
“…The protein RABG3B is located at the surface of the autophagosome, however, it remains unclear whether RABG3B can regulate the fusion of the autophagosome and vacuole in plants. It is suggested that the homologous yeast proteins such as Ykt6, Vam3, Ypt7, and complex HOPS are involved in the fusion of autophagosome and vacuole in plants [46,82]. Moreover, it is also suggested that the plant components of the ESCRT complex, such as the charged multi-vesicular body protein 1 (CHMP1), FYVE-domain protein required for endosomal sorting 1 (FREE1), vacuolar protein sorting 2.1 (VPS2.1), cell death-related endosomal FYVE/SYLF protein 1 (CFS1), and plant exocyst complex component EXO70B1 (EXO70B1) are involved in trafficking of the autophagosome, the fusion of autophagosome and vacuole, and the release of the autophagic body into the vacuole [25].…”
Section: Fusion Of the Autophagosome With The Vacuole And Formation Omentioning
confidence: 99%