To Evaluate the Association of Stress with Serum Cortisol and Serum Homocysteine Levels in Patients of Central Serous Chorioretinopathy

Meena, Khushboo

doi:10.21088/oas.2454.7816.6120.8

Cited by 2 publications

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“…It has been noted that the oral, intravenous, intranasal, and intraarticular administration of corticosteroid preparations, as well as increased levels of endogenous glucocorticoids, are significant risk factors for the development of CSCR [ 68 – 70 ]. Moreover, increased levels of endogenous cortisol have been found in the urine and blood of patients with CSCR [ 71 , 72 ]. Some authors proposed that corticosteroids could damage the outer blood-retinal barrier and increase the permeability of the RPE and choriocapillaris, leading to subretinal fluid accumulation [ 22 , 46 ].…”

Section: Corticosteroids and Inflammationmentioning

confidence: 99%

Unraveling the Puzzle of Central Serous Chorioretinopathy: Exploring Psychological Factors and Pathophysiological Mechanisms

et al. 2023

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Central serous chorioretinopathy (CSCR) is a relatively common retinal disease involving the localized serous detachment of the neurosensory retina from the retinal pigment epithelium (RPE). Research suggests that individuals with a Type A personality, exhibiting traits such as competitiveness, urgency, aggression, and hostility, are significantly more prone to developing CSCR. Several studies have confirmed that a propensity to stress as well as different stressful events may predispose subjects to the development and recurrence of CSCR. Patients with CSCR are more depressive, report a higher level of anxiety and use more psychopharmacologic medications. Despite the research conducted on the topic, it remains unclear how a variety of psychological factors can contribute to dysfunction and pathological changes in the choroid and RPE. Some authors propose that increased levels of sympathetic neurotransmitters and glucocorticoids may alter the choroidal blood flow and increase the permeability of choriocapillaris in CSCR patients. It is generally accepted that hyperpermeable choroidal vessels are responsible for increased tissue hydrostatic pressure, which promotes RPE detachment, breaks the barrier function of the RPE and leads to subretinal fluid accumulation. Although the etiological factors and pathophysiological mechanisms have still not been fully clarified, CSCR is most likely a multifactorial disease involving disturbed interrelationships between biological and psychological factors. This comprehensive review aims to provide an up-to-date exploration of the psychological factors and pathophysiological mechanisms associated with CSCR.

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Section: Corticosteroids and Inflammationmentioning

confidence: 99%

Unraveling the Puzzle of Central Serous Chorioretinopathy: Exploring Psychological Factors and Pathophysiological Mechanisms

et al. 2023

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“…Stillbirths that occur after the 20th week of pregnancy but for unknown reasons remain agonising and challenging in perinatal care. Despite advancements in prenatal care and diagnostic in-struments, the causes of many stillbirths remain a mystery, leaving parents and medical professionals feeling helpless in the face of such tragedy [1]. To improve prenatal care and reduce the occurrence of these tragic occurrences, it is crucial to investigate possible connections between various biomarkers and unexplained stillbirths.One such biomarker of relevance is serum homocysteine, an amino acid created during methionine metabolism [2].…”

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confidence: 99%

Association of Serum Homocysteine Levels With Unexplained Stillbirths

Suman

Sinha

Singh

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Background This study examines the concept that elevated homocysteine levels are associated with sudden infant death syndrome. The study aimed to determine whether elevated serum homocysteine levels were related with an increased risk of iatrogenic stillbirths. Method In this retrospective case-control study, 100 women who had stillbirths for unknown reasons and 100 who had normal pregnancies served as cases and controls, respectively. The serum homocysteine levels were evaluated using enzyme assays, and other pertinent clinical and demographic information was also gathered. Result Significantly differing homocysteine levels were found between the case group (mean ± standard deviation: 12.5 ±2.1 units) and the control group (mean± standard deviation: 8.3± 1.5 units; p0.001). After adjusting for potential confounding factors Conclusion The results suggest that elevated serum homocysteine levels may be a biomarker for the unknown risk of stillbirth in women. Further research is required into potential treatments and prevention strategies for hyperhomocysteinemia-related pregnancy complications. This study supports the theory that elevated homocysteine levels induce sudden infant death syndrome. Significant therapeutic implications result from these findings, as systematic homocysteine monitoring throughout pregnancy may help identify high-risk patients and implement appropriate therapies to reduce stillbirths. Recommendation There is a need for additional research to validate these findings and investigate methods to reduce maternal homocysteine levels.uch as maternal age, smoking status, and gestational age, logistic regression analysis revealed a important association between elevated serum homocysteine levels and unexplained stillbirths (odds ratio: 2.90, 95% confidence interval: 1.70-4

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To Evaluate the Association of Stress with Serum Cortisol and Serum Homocysteine Levels in Patients of Central Serous Chorioretinopathy

Cited by 2 publications

References 0 publications

Unraveling the Puzzle of Central Serous Chorioretinopathy: Exploring Psychological Factors and Pathophysiological Mechanisms

Unraveling the Puzzle of Central Serous Chorioretinopathy: Exploring Psychological Factors and Pathophysiological Mechanisms

Association of Serum Homocysteine Levels With Unexplained Stillbirths

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