To evaluate the microcirculation of retinochoroid capillary between acute and chronic central serous chorioretinopathy with OCTA

Abstract

To investigate the difference in chorioretinal microcirculation between acute central serous chorioretinopathy (aCSC) and chronic central serous chorioretinopathy (cCSC) using optical coherence tomography angiography. In total, 65 patients previously diagnosed with central serous chorioretinopathy (33 aCSC and 32 cCSC) were included in our cross-sectional study. All patients underwent complete ophthalmologic assessment including logarithm of the minimum angle of resolution best-corrected visual acuity, fundus fluorescein angiography, and optical coherence tomography angiography. Sixty eyes of 60 refractive error and age matched healthy people were selected as control. The vessel density of inner retina in patients with aCSC were higher than that in patients with cCSC (51.32 ± 2.01 vs 49.15 ± 3.68, P = .004), however, the vessel density of superficial choroid layer in aCSC were significantly lower than that in cCSC (49.83 ± 6.96 vs 53.42 ± 6.28, P = .033). Further analysis of the data reveals the presence of a distinct choroidal neovascularization (CNV) in 8 patients (25%) with cCSC while there was no evidence of CNV in patients with aCSC. Our study can contribute to a better understanding of the difference in retinochoroid microcirculation between aCSC and cCSC. The vessel density of inner retina was lower and the vessel density of superficial choroid was higher in cCSC, and patients with cCSC were more susceptible to CNV than patients with aCSC.

Evaluation of Predictive Factors Associated with Resolution of Acute Central Serous Chorioretinopathy

“…In agreement with that, Cakir et al [25] , Wang et al [26] , Han et al [27] and Lu et al [28] concluded that the vessel density of superficial CC was significantly lower in eyes with acute CSC than in fellow eyes and in age and refractive error matched normal eyes.…”

Active-fluidics versus gravity-fluidics system in phacoemulsification for age-related cataract (AGSPC): study protocol for a prospective, randomised, double-blind, controlled clinical trial

“…40 Changes in the microcirculation of the retina may be an early stage of some diseases but relevant mechanism has not been studied in sufficient detail. [41][42][43] It is not yet clear whether there is a correlation between perfusion pressure, CDE and vessel density, between changes in blood flow and changes in retinal thickness or macular oedema. Our study will devote to analysing the clinical significance of changes in vessel density after cataract surgery and whether there is a difference in the effect of surgery on blood flow under the two systems.…”

“…Thanks to the advent of OCTA, which helps to visualise and analyse the retinal vasculature in a non-invasive way and allows quantitative calculation of vessel density with the aid of specific software 40. Changes in the microcirculation of the retina may be an early stage of some diseases but relevant mechanism has not been studied in sufficient detail 41–43. It is not yet clear whether there is a correlation between perfusion pressure, CDE and vessel density, between changes in blood flow and changes in retinal thickness or macular oedema.…”

Quantitative analysis of choroidal vasculature in central serous chorioretinopathy using ultra-widefield swept-source optical coherence tomography angiography

“…Similar to previous studies, we found higher density of choriocapillaris in cCSC than in aCSC at the inferotemporal subfield. We hypothesized that the hypoperfusion with surrounding hyperperfusion on OCTA may be the compensatory status due to ischemia in cCSC [31][32][33] . However, in contrary to some published studies 34,35 , we found the choroidal thickness and volume, as well as large-vessel density were higher in the aCSC group.…”