To Evaluate the Role of Bone Marrow Aspiration and Bone Marrow Biopsy in Pancytopenia

Desalphine, Melina; Bagga, Permeet Kaur; Gupta, Parmod; Kataria, Amarjit Singh

doi:10.7860/jcdr/2014/9042.5169

Cited by 16 publications

(22 citation statements)

References 9 publications

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“…Megaloblastic anaemia was found to be predominant in various Indian studies because of high prevalence of nutritional anaemia in the Indian subcontinent. Most common complaints in their study and other Indian studies were fever followed by weakness and bleeding tendencies [2]. Vitamin B 12 is essential for normal blood synthesis and neurological function.…”

Section: Understanding About Common Cause Of Pancytopeniamentioning

confidence: 99%

“…Bone marrow aspiration and biopsy evaluation along with good clinical correlation are of utmost importance to evaluate the causes of pancytopenia and plan further investigations [2]. Pancytopenia is a common hematological problem with an extensive differential diagnosis, and the optimal diagnostic approach to pancytopenia remains undefined.…”

mentioning

confidence: 99%

“…Its greatest utility is for investigating and it is an important diagnostic modality for evaluating the causes of pancytopenia [2]. In pancytopenia, the marrow can be hypocellular or hypercellular.…”

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confidence: 99%

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Detection of Pancytopenia Associated with Clinical Manifestation and Their Final Diagnosis

Azaad¹,

Li²,

Zhang³

et al. 2015

OJBD

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Section: Understanding About Common Cause Of Pancytopeniamentioning

confidence: 99%

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confidence: 99%

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Detection of Pancytopenia Associated with Clinical Manifestation and Their Final Diagnosis

Azaad¹,

Li²,

Zhang³

et al. 2015

OJBD

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“…The causes of pancytopenia are diverse in different population or geographical areas. According to various studies from different parts of the world including some parts of India the commonest underlying cause of pancytopenia is hypoplastic anemia and its frequency varies from 10% to over 50% [4,7,8,[12][13][14][15]. Our experience in this study is different.…”

Section: Discussionmentioning

confidence: 76%

“…A total hematopathological work up is essential to find out the etiology of pancytopenia to plan case wise proper therapeutic strategies [3]. Thus performing a complete blood count (CBC), bone marrow aspiration/ imprint cytology and bone marrow trephine biopsy are very vital in the overall management of the pancytopenic patients [4]. In order to reach the final diagnosis sometimes immunophenotyping, cytogenetic analysis and molecular genetic studies etc.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic evaluation of pancytopenia - a prospective institutional study in North-East India

et al. 2016

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Introduction: Pancytopenia, the simultaneous reduction of all the three formed elements of blood, is diverse in its etiology. Full clinico-hematopathological work up is crucial in each case. This study was undertaken with the objectives of identifying the causes of pancytopenia and its phenotypic characteristics in relation to age, sex, ethnicity and socioeconomic status. Methods: Ninety two cases of pancytopenia studied here were diagnosed by complete hemogram study in automated hematology analyzer. Peripheral blood smear studies were carried out. All cases were subjected to bone marrow aspiration/ imprint smear cytology and trephine biopsy study. Hypoplastic anemia cases were investigated for paroxysmal nocturnal hemoglobinuria (PNH) with flow cytometric analysis of red blood cells treated with CD55 and CD59 antibodies. Results: Fifty eight percent of cases were males and mean age was 52 years. Children constituted 16% of patients. Thirty-seven percent of cases belonged to tribal community. Around 70% belonged to low socioeconomic status. Causes of pancytopenia detected were primary hematological malignancies (Total 39.2 % with acute leukaemia 35.9%, lymphoma 2.2% and multiple myeloma 1.1%), hypoplastic anaemia (28.3%), myelodysplastic syndrome (MDS) (21.7%), megaloblastic Anemia (6.5%) and hypersplenism (4.3%). No PNH clone was detected amongst hypoplastic anemia cases. Conclusion: It is concluded that pancytopenia often is the manifestation of serious disease-processes and the commonest cause, in our population of this NorthEastern state of Tripura, being acute leukemia. Bone marrow cytology and biopsy study must be performed in all cases of pancytopenia to find out the cause in order to institute an early treatment.

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Concomitant manifestations of systemic lupus erythematosus flare‐up and nodal marginal zone B‐cell lymphoma in a 41‐year‐old male patient: A challenging case report

Zarafshani,

Rahmanian,

Manouchehri Ardekani

et al. 2024

Clinical Case Reports

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Key Clinical MessageMalignancy may be a possible cause of systemic lupus erythematosus (SLE) flare‐ups, and it is necessary to consider it in the context of treatment resistance. In this case, we present a challenging instance of concomitant nodal marginal zone B‐cell lymphoma (NMZL) and SLE flare‐up in a 41‐year‐old male patient.AbstractSystemic lupus erythematosus (SLE) is a chronic autoimmune disease that can cause various symptoms and affect multiple organs in the body. It is also associated with the development of malignancies, especially lymphomas. This case report discusses a patient who experienced a flare‐up of SLE along with hypercalcemia, which led to the diagnosis of nodal marginal zone B‐cell lymphoma (NMZL). This is the first case of its kind to be reported. A 41‐year‐old man with a 10‐year history of SLE and antiphospholipid syndrome (APS) was referred to our center due to several symptoms, including fatigue, oral lesions, dyspnea, bilateral wrist pain and inflammation, mild pericardial effusion, organ enlargement, pancytopenia, high erythrocyte sedimentation (ESR) level, high anti‐double stranded DNA (anti‐dsDNA) level, low complement level, resistant hypercalcemia, and high brain natriuretic peptide (pro‐BNP) level. After further testing, it was discovered that the patient had NMZL, which was the ultimate diagnosis. He underwent six cycles of the R‐CHOP chemotherapy regimen, and his clinical and laboratory conditions improved during follow‐ups. The initial case of SLE flare‐up, with concomitant NMZL is being reported as the final diagnosis. In simpler terms, it is possible for lymphoma to manifest as a potential cause of SLE flare‐ups, and clinicians should be mindful that they need to consider malignant conditions when faced with treatment resistance.

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To Evaluate the Role of Bone Marrow Aspiration and Bone Marrow Biopsy in Pancytopenia

Cited by 16 publications

References 9 publications

Detection of Pancytopenia Associated with Clinical Manifestation and Their Final Diagnosis

Detection of Pancytopenia Associated with Clinical Manifestation and Their Final Diagnosis

Diagnostic evaluation of pancytopenia - a prospective institutional study in North-East India

Concomitant manifestations of systemic lupus erythematosus flare‐up and nodal marginal zone B‐cell lymphoma in a 41‐year‐old male patient: A challenging case report

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