To grow and to stay, both controlled by RhoA: Opposing cellular effects on axon regeneration

Hintermayer, Matthew A; Drake, Sienna S.; Fournier, Alyson E.

doi:10.1016/j.neuron.2021.10.009

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…Ras homolog family member A (RhoA), on the other hand, is a well-characterized cytoskeleton regulating factor with extensive roles in neuronal survival and in axon growth and regeneration ( 19 , 32 , 33 ). Local translation of RHOA has been reported in embryonic axon growth cone collapse and in inhibitory axon growth pathways in embryonic and postnatal neurons ( 34 , 35 ), with a tightly regulated dynamics of local synthesis coupled with localized degradation to control RhoA activation in the growth cone ( 36 ).…”

Section: Discussionmentioning

confidence: 99%

PTBP1 regulates injury responses and sensory pathways in adult peripheral neurons

et al. 2023

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Polypyrimidine tract binding protein 1 (PTBP1) is thought to be expressed only at embryonic stages in central neurons. Its down-regulation triggers neuronal differentiation in precursor and non-neuronal cells, an approach recently tested for generation of neurons de novo for amelioration of neurodegenerative disorders. Moreover, PTBP1 is replaced by its paralog PTBP2 in mature central neurons. Unexpectedly, we found that both proteins are coexpressed in adult sensory and motor neurons, with PTBP2 restricted mainly to the nucleus, while PTBP1 also shows axonal localization. Levels of axonal PTBP1 increased markedly after peripheral nerve injury, and it associates in axons with mRNAs involved in injury responses and nerve regeneration, including importin β1 (KPNB1) and RHOA. Perturbation of PTBP1 affects local translation in axons, nociceptor neuron regeneration and both thermal and mechanical sensation. Thus, PTBP1 has functional roles in adult axons. Hence, caution is required before considering targeting of PTBP1 for therapeutic purposes.

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