To investigate the effect of <i>Citrullus colocynthis</i> (Schrad) fruit on oxidative stress parameters in type 2 diabetic patients

Husein, H Fallah; Zaree, AB; Sharifabad, R Rezaii; Heshmat, Ramin; Larijani, Bagher

doi:10.1111/j.2042-7166.2006.tb04745.x

Cited by 3 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Undamaged Garlic (swallowed) had no improving effect on serum lipid level but crushed Garlic (chewed) reduced cholesterol, triglyceride, lipid peroxidation, and blood pressure [14]. Two randomized clinical trial showed no significant antilipidemic effect of Citrullus colocynthis L and Satureja Khuzestanica in diabetic patients [19,20]. Of course, small groups of patients were included in these two studies.…”

Section: Discussionmentioning

confidence: 99%

“…Mey reduce lipid peroxidation and increase total antioxidant power in healthy subjects [11,13]. Gluthation, catalaze, malondialdehyde, superoxide dismutase do not change with Cytrollus colocynthis [19].…”

Section: Human Studiesmentioning

confidence: 91%

“…Of publications identified in the initial database search, 10 trials on the efficacy of medicinal plants were reviewed [11][12][13][14][15][16][17][18][19][20]. Information of these clinical trials is summarized in the Table 1.…”

Section: Human Studiesmentioning

confidence: 99%

See 2 more Smart Citations

A Systematic Review of the Potential Herbal Sources of Future Drugs Effective in Oxidant-Related Diseases

Hasani‐Ranjbar¹,

Larijani²,

Abdollahi

2009

IADT

176

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Human Studiesmentioning

confidence: 91%

See 1 more Smart Citation

A Systematic Review of the Potential Herbal Sources of Future Drugs Effective in Oxidant-Related Diseases

Hasani‐Ranjbar¹,

Larijani²,

Abdollahi

2009

IADT

176

View full text Add to dashboard Cite

show abstract

“…Mechanism of this protective effect of C. colocynthis against high glucose condition is not clearly understood yet. In previous studies on the experimental model of diabetes and clinical trials in type 2 diabetic patients, we have shown that C. colocynthis has antioxidant properties in addition to its hypoglycemic function [8,[11][12].…”

Section: Discussionmentioning

confidence: 99%

“…Experimental studies have reported its antidiabetic and antioxidant properties [9 -11]. The anti-diabetic and antioxidant effects of C. colocynthis were also observed in clinical trials [12,13]. In order to provide evidence on mechanism of action of C. colocynthis in diabetic condition in neuronal cells, the protective effect of the methanolic extract and fractions of the fruits of C. colocynthis was investigated in high glucose treated PC-12 cells.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of Citrullus colocynthis (L.) Schard. fruit extract on high glucose-induced neurotoxicity in PC-12 cells

et al. 2021

View full text Add to dashboard Cite

Background: Diabetic neuropathy is a consequence of chronic hyperglycemia that leads to neural damage over time. The fruits of Citrullus colocynthis (L.) Schard. (C. colocynthis) have long been used in Iranian traditional medicine for treatment of diabetes. Objective: In this study, we investigated the protective effects of C. colocynthis against high glucose-induced neurotoxicity in PC-12 cells as a suitable in vitro model for neuronal functions. Methods: The seedless dry fruit powder was extracted with methanol and then dried by rotary evapoartion. Later the obtain extract was fractionated as hexane, chloroform, ethyl acetate, and n-butanol fractions and aqueous residue. HPLC method was used for qualitative analysis of colocynthin in C. colocynthis pulp. The PC-12 cell viability of total extract and fractions of C. colocynthis were evaluated by means of dose and time in high glucose medium in PC-12 cells as a suitable culture model for studying neuronal functions through MTT assay. Results: The PC-12 cell viability significantly decreased in wells containing high glucose, compared with normal glucose treated cells. C. colocynthis extract treatment significantly enhanced the cells viability under toxic high glucose condition in a dose and time depending manner. Methanol extract of C. colocynthis exhibited a protective effect against high glucoseinduced cytotoxicity in PC-12 cells. Conclusion: C. colocynthis has neuroprotective properties against high glucose condition in vitro.

show abstract

Effect of fruit on glucose control in diabetes mellitus: a meta-analysis of nineteen randomized controlled trials

Ren

Sun

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

ObjectiveDiabetes mellitus is a worldwide health problem, and it remains unclarified whether fruit is beneficial in glycemic control. This study aimed to analyze evidence from randomized controlled trials evaluating the effect of fruit consumption on glucose control.MethodsWe searched the PubMed, EMBASE, Ovid, Web of Science, and Cochrane Central Register of Controlled Trials databases from the respective database inception dates to December 30, 2022, to identify randomized controlled trials that evaluated the effects of fruit consumption on glucose control. Two researchers independently screened the studies in accordance with the inclusion and exclusion criteria, and performed the literature quality evaluation and data extraction. RevMan 5.4 software was used to perform the data analysis.ResultsNineteen randomized controlled trials with 888 participants were included. Fruit consumption significantly decreased the fasting blood glucose concentration (MD -8.38, 95% CI -12.34 to -4.43), but it showed no significant difference in the glycosylated hemoglobin (MD -0.17, 95% CI -0.51 to 0.17). Subgroup analyses further suggested that the consumption of both fresh and dried fruit decreased the fasting blood glucose concentration.ConclusionsIncreasing the fruit intake reduced fasting blood glucose concentration. Therefore, we recommend that patients with diabetes eat more fruits while ensuring that their total energy intake remains unchanged.

show abstract

To investigate the effect of Citrullus colocynthis (Schrad) fruit on oxidative stress parameters in type 2 diabetic patients

Cited by 3 publications

References 0 publications

A Systematic Review of the Potential Herbal Sources of Future Drugs Effective in Oxidant-Related Diseases

A Systematic Review of the Potential Herbal Sources of Future Drugs Effective in Oxidant-Related Diseases

Protective effect of Citrullus colocynthis (L.) Schard. fruit extract on high glucose-induced neurotoxicity in PC-12 cells

Effect of fruit on glucose control in diabetes mellitus: a meta-analysis of nineteen randomized controlled trials

Contact Info

Product

Resources

About