To investigate the thermodynamic parameters of Li, Na and K salt of L leucinate at various temperature and concentration by conductometric measurement

Abstract

Recently in this laboratory the conductometric measurement of aqueous solutions of Li, Na and K salt of L-leucine were studied at different temperature and molar concentration to investigate the solute-solvent, ion-solvent interactions (solute means drug) and also the effect of dilution was investigated. During this work the thermodynamic parameters (change in free energy, change in entropy and change in enthalpy) were investigated at concentrations range (0.01 to 0.15) M and at various temperature 298.15, 303.15, 308.15, and 313.15 K. The thermodynamic parameters helps to understand a solute-solute, solute-solvent and solvent-solvent interaction and this information will also be helpful to understand pharmacokinetics and pharmacodynamics of these drug salts.