To: Krebs M, Brehm A, Krssak M et al. (2003) Direct and indirect effects of amino acids on hepatic glucose metabolism in humans. Diabetologia 46:917?925

Burns, Shamus P.; Cohen, Robert

doi:10.1007/s00125-003-1254-x

Cited by 3 publications

(3 citation statements)

References 3 publications

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“…This might be explained by a consistent underestimation of the EGP by the tracer model, as part of the diluted tracer pool, due to newly produced glucose, is taken up by the liver again. 55 These limitations, however, do not weaken the conclusions drawn from our study. Finally, although our study does not provide data on reduced glucose infusion for longer than 4 h this approach appears to be safe in the initial postoperative phase which duration is individually dependent but usually lasts 6-24 h. Confirmatory studies with reduced glucose infusion during this study period are warranted.…”

Section: Discussionmentioning

confidence: 58%

Reducing glucose infusion safely prevents hyperglycemia in post-surgical children

et al. 2011

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Section: Discussionmentioning

confidence: 58%

Reducing glucose infusion safely prevents hyperglycemia in post-surgical children

et al. 2011

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“…First, glycogenolysis rates in some patients were negative during SG, but this is physiologically not possible. This may have resulted from an underestimation of EGP because of dilution of the tracer pool by re-uptake of newly produced glucose in the liver as a consequence of hepatic intralobular functional heterogeneity [59]. Second, we did not measure cerebral glucose uptake as the lower limit [17] and glucose oxidation rates as the upper limit [18] of glucose intake.…”

Section: Discussionmentioning

confidence: 99%

Does a reduced glucose intake prevent hyperglycemia in children early after cardiac surgery? a randomized controlled crossover study

et al. 2012

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IntroductionHyperglycemia in children after cardiac surgery can be treated with intensive insulin therapy, but hypoglycemia is a potential serious side effect. The aim of this study was to investigate the effects of reducing glucose intake below standard intakes to prevent hyperglycemia, on blood glucose concentrations, glucose kinetics and protein catabolism in children after cardiac surgery with cardiopulmonary bypass (CPB).MethodsSubjects received a 4-hour low glucose (LG; 2.5 mg/kg per minute) and a 4-hour standard glucose (SG; 5.0 mg/kg per minute) infusion in a randomized blinded crossover setting. Simultaneously, an 8-hour stable isotope tracer protocol was conducted to determine glucose and leucine kinetics. Data are presented as mean ± SD or median (IQR); comparison was made by paired samples t test.ResultsEleven subjects (age 5.1 (20.2) months) were studied 9.5 ± 1.9 hours post-cardiac surgery. Blood glucose concentrations were lower during LG than SG (LG 7.3 ± 0.7 vs. SG 9.3 ± 1.8 mmol/L; P < 0.01), although the glycemic target (4.0-6.0 mmol/L) was not achieved. No hypoglycemic events occurred. Endogenous glucose production was higher during LG than SG (LG 2.9 ± 0.8 vs. SG 1.5 ± 1.1 mg/kg per minute; P = 0.02), due to increased glycogenolysis (LG 1.0 ± 0.6 vs. SG 0.0 ± 1.0 mg/kg per minute; P < 0.05). Leucine balance, indicating protein balance, was negative but not affected by glucose intake (LG -54.8 ± 14.6 vs. SG -58.8 ± 16.7 μmol/kg per hour; P = 0.57).ConclusionsCurrently recommended glucose intakes aggravated hyperglycemia in children early after cardiac surgery with CPB. Reduced glucose intake decreased blood glucose concentrations without causing hypoglycemia or affecting protein catabolism, but increased glycogenolysis.Trial registrationDutch trial register NTR2079.

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“…It is therefore not surprising that fetal malnutrition has lasting effects on the liver. In rats exposed in utero to a low protein diet, there are fewer but larger liver lobules 48 . In adulthood, the response of these livers to glucagon or glucagon plus insulin infusion is altered, glucose output consequent to glucagon stimulation being reduced while addition of insulin resulted in an anomalous initial increase in glucose output followed later by the expected reduction.…”

Section: Livermentioning

confidence: 99%

Long-term health consequences of poor nutrition during pregnancy

Miese-Looy

Rollings-Scattergood

Yeung

2008

SURG

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The long-term effects of poor prenatal nutrition are becoming a matter of increasing concern throughout the world. While the consequences of inadequate caloric and/or vitamin intake during pregnancy have been well characterized, in recent years it has become clear that serious long-term adverse effects may also result from gestational nutrient imbalance, even when total caloric intake is more than sufficient to meet the demands of pregnancy. Excessive fat, carbohydrate or protein intake may permanently alter the homeostatic mechanisms in the fetus, predisposing the offspring of affected pregnancies to serious chronic diseases, including cardiovascular disease, diabetes and cancer. This review summarizes the growing literature on this subject, with particular emphasis on the lasting health-related effects of macronutrient imbalance on fetal development.

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To: Krebs M, Brehm A, Krssak M et al. (2003) Direct and indirect effects of amino acids on hepatic glucose metabolism in humans. Diabetologia 46:917?925

Cited by 3 publications

References 3 publications

Reducing glucose infusion safely prevents hyperglycemia in post-surgical children

Reducing glucose infusion safely prevents hyperglycemia in post-surgical children

Does a reduced glucose intake prevent hyperglycemia in children early after cardiac surgery? a randomized controlled crossover study

Long-term health consequences of poor nutrition during pregnancy

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