To normalize or not to normalize? Fat is the question

Hebert, Craig E.; Keenleyside, Karen

doi:10.1002/etc.5620140509

Cited by 224 publications

(131 citation statements)

References 17 publications

Supporting

Mentioning

127

Contrasting

Unclassified

Order By: Relevance

“…Because timing in the reproductive cycle plays a major role in the natural oscillations of circulating hormones, correlations (coefficients) between TH and OC levels were adjusted for day of capture in the incubation period. Likewise, OC levels (ww basis) were corrected for plasma fat content because of their lipophilic properties, using extractable plasma fat (percent of whole blood; Hebert and Keenleyside 1995). Correlations are expressed using the Pearson correlation coefficient (r).…”

Section: Methodsmentioning

confidence: 99%

Effects of organochlorine contaminants on thyroid hormone levels in Arctic breeding glaucous gulls, Larus hyperboreus.

Verreault

Skaare

Jenssen

et al. 2004

Environ Health Perspect

View full text Add to dashboard Cite

Studies on glaucous gulls (Larus hyperboreus) breeding in the Barents Sea have reported that high blood levels of halogenated organic contaminants in this species might cause reproductive, behavioral, and developmental stress. However, potential endocrine system modulation caused by contaminant exposure has yet not been reported in this Arctic apical predator. In this present study we aimed to investigate whether the current levels of a selection of organochlorines (OCs) were associated with altered circulating levels of thyroid hormones (THs) in free-ranging adult glaucous gulls breeding at Bear Island in the Barents Sea. Blood concentrations of 14 polychlorinated biphenyls, hexachlorobenzene (HCB), oxychlordane, and p,p´-dichlorodiphenyldichloroethylene (p,p´-DDE) were quantified, in addition to free and total thyroxine (T 4 ) and triiodothyronine (T 3 ), in plasma of 66 glaucous gulls in the spring of 2001. Negative correlations were found between plasma levels of T 4 and T 4 :T 3 ratio, and blood levels of OCs in male glaucous gulls. Despite their relatively low contribution to the total OC fraction, HCB and oxychlordane were the most prominent compounds in terms of their negative effect on the variation of the T 4 :T 3 ratio. Moreover, lower T 4 levels and T 4 :T 3 ratios were measured in glaucous gulls breeding in a colony exposed to high levels of OCs, compared with a less exposed colony. Levels of T 3 were elevated in the high-OC-exposed colony. This may indicate that the glaucous gull is susceptible to changes to TH homeostasis mediated by exposure to halogenated organic contaminants.

show abstract

Section: Methodsmentioning

confidence: 99%

Effects of organochlorine contaminants on thyroid hormone levels in Arctic breeding glaucous gulls, Larus hyperboreus.

Verreault

Skaare

Jenssen

et al. 2004

Environ Health Perspect

View full text Add to dashboard Cite

show abstract

“…28,52,101,118,138,153,180) and DDT compounds (p,p 0 -DDE, p,p 0 -DDD and p,p 0 -DDT). Keenleyside, 1995;Pastor et al, 1996). The wild sea bass show a significantly higher amount of pollutants in their muscles compared to the sea bass from aquaculture, especially in total PCBs and DDE lipid-normalized concentration.…”

Section: ± 136 180 ± 95 This Workmentioning

confidence: 99%

Effects of persistent organic pollutants on the thyroid function of the European sea bass (Dicentrarchus labrax) from the Aegean sea, is it an endocrine disruption?

Schnitzler¹,

Koutrakis²,

Siebert³

et al. 2008

Marine Pollution Bulletin

View full text Add to dashboard Cite

Article history: Available online xxxx a b s t r a c tWe evaluated the alterations of organochlorinated compounds such as polychlorobiphenyls (PCB), dichloro-diphenyl-dichloroethylene (DDE) and dichloro-diphenyl-trichloroethane (DDT) on the thyroid in wild and cultured sea bass (Dicentrarchus labrax) at environmental concentrations. These compounds influence the endocrine system of many fish species and are qualified as endocrine disruptors. The thyroid seems to be a target organ. Two alteration endpoints: the thyroid histology and the muscular thyroid hormone concentrations, were used simultaneously. High concentrations in PCBs and DDT were detected in muscles, supporting the idea that the Mediterranean fauna could be more polluted than the Atlantic fauna. The high abundance of DDE indicates a progressive degradation of remnant DDT load and the absence of new inputs in this area. Aquaculture sea bass shows a significant higher amount of pollutants on fresh weight basis (especially PCBs) in their muscles compared to the wild sea bass. Those differences may be related mainly to the contaminations of diet. Thyroid parameters vary between wild and aquaculture sea bass, wild sea bass were characterized by higher follicle diameters, epithelial cell heights and muscular T 4 concentrations. A significant relationship between persistent organic pollutants (muscular PCBs and DDT concentration) and the different thyroid parameters (diameters of follicles, epithelial cell heights and muscular T 4 levels) could be observed, which support the hypothesis that these compounds have an adverse impact on thyroid morphometry and function.

show abstract

“…Differences in p,p'DDE concentrations were highest (87 percent) in samples of different species (common carp and largescale sucker), possibly due to 39 percent higher lipid content in the common carp. Organochlorine compounds are typically lipophilic, which suggests that these compounds accumulate in proportion to tissue lipid content (Hebert and Keenleyside, 1995). Concentrations of p,p'DDE in samples of the same species from multiple-reach sites were similar; differences ranged from 8 to 26 percent.…”

Section: Field and Laboratory Quality Assurancementioning

confidence: 99%

Organochlorine compounds in fish tissue and bed sediment in the upper Snake River basin, Idaho and western Wyoming, 1992-94

Maret¹,

Ott²

1997

View full text Add to dashboard Cite

To normalize or not to normalize? Fat is the question

Cited by 224 publications

References 17 publications

Effects of organochlorine contaminants on thyroid hormone levels in Arctic breeding glaucous gulls, Larus hyperboreus.

Effects of organochlorine contaminants on thyroid hormone levels in Arctic breeding glaucous gulls, Larus hyperboreus.

Effects of persistent organic pollutants on the thyroid function of the European sea bass (Dicentrarchus labrax) from the Aegean sea, is it an endocrine disruption?

Organochlorine compounds in fish tissue and bed sediment in the upper Snake River basin, Idaho and western Wyoming, 1992-94

Contact Info

Product

Resources

About