To sleep, perchance to live

Hunter, Philip

doi:10.1038/embor.2008.197

Cited by 9 publications

(4 citation statements)

References 11 publications

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“…Previous studies have shown improved cognitive function after the improvement of sleep quality and quantity. 47,48 Therefore, the improvement in cognitive ability after follow-up in gabapentin treatment may be associated with sleep improvements.…”

Section: Discussionmentioning

confidence: 97%

Treatment Effects of Gabapentin for Primary Insomnia

Lo¹,

Yang²,

Lo³

et al. 2010

Clinical Neuropharmacology

104

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Section: Discussionmentioning

confidence: 97%

Treatment Effects of Gabapentin for Primary Insomnia

Lo¹,

Yang²,

Lo³

et al. 2010

Clinical Neuropharmacology

104

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“…Circadian organization optimizes organismal function at all levels of biological organization [ 4 , 39 , 40 ]. A faltering circadian organization generates symptoms that range from the fairly minor, such as jet lag, to life limiting disorders like depression, metabolic syndrome, cardiovascular or gastrointestinal disease, or cancer [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

“…A faltering circadian organization generates symptoms that range from the fairly minor, such as jet lag, to life limiting disorders like depression, metabolic syndrome, cardiovascular or gastrointestinal disease, or cancer [ 41 ]. A breakdown of circadian organization can result in death in lab animals and may contribute to death in humans [ 39 , 42 - 45 ].…”

Section: Discussionmentioning

confidence: 99%

The association of quality of life with potentially remediable disruptions of circadian sleep/activity rhythms in patients with advanced lung cancer

et al. 2011

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BackgroundCancer patients routinely develop symptoms consistent with profound circadian disruption, which causes circadian disruption diminished quality of life. This study was initiated to determine the relationship between the severity of potentially remediable cancer-associated circadian disruption and quality of life among patients with advanced lung cancer.MethodsWe concurrently investigated the relationship between the circadian rhythms of 84 advanced lung cancer patients and their quality of life outcomes as measured by the EORTC QLQ C30 and Ferrans and Powers QLI. The robustness and stability of activity/sleep circadian daily rhythms were measured by actigraphy. Fifty three of the patients in the study were starting their definitive therapy following diagnosis and thirty one patients were beginning second-line therapy. Among the patients who failed prior therapy, the median time between completing definitive therapy and baseline actigraphy was 4.3 months, (interquartile range 2.1 to 9.8 months).ResultsWe found that circadian disruption is universal and severe among these patients compared to non-cancer-bearing individuals. We found that each of these patient's EORTC QLQ C30 domain scores revealed a compromised capacity to perform the routine activities of daily life. The severity of several, but not all, EORTC QLQ C30 symptom items correlate strongly with the degree of individual circadian disruption. In addition, the scores of all four Ferrans/Powers QLI domains correlate strongly with the degree of circadian disruption. Although Ferrans/Powers QLI domain scores show that cancer and its treatment spared these patients' emotional and psychological health, the QLI Health/Function domain score revealed high levels of patients' dissatisfaction with their health which is much worse when circadian disruption is severe. Circadian disruption selectively affects specific Quality of Life domains, such as the Ferrans/Powers Health/Function domain, and not others, such as EORTC QLQ C30 Physical Domain.ConclusionsThese data suggest the testable possibility that behavioral, hormonal and/or light-based strategies to improve circadian organization may help patients suffering from advanced lung cancer to feel and function better.

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“…Circadian molecular clocks directly or indirectly synchronize these interacting systems at all levels of biological complexity. 1,2 Circadian clocks regulate clinically important biological functions such as heart rate, serum glucose levels, pain, renal function, immune function, and other physiological or psychological variables that affect an individual’s clinical status. 3,4 Mammals have a small number of photoreceptor cells in their eyes called photosensitive retinal ganglion cells.…”

Section: Introductionmentioning

confidence: 99%

Advanced cancer patients in a randomized clinical trial of night-simulating eyeglasses observed to have a normal 24-h circadian rhythm during chemotherapy

et al. 2022

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Objectives: Cancer patients routinely exhibit dysfunctional circadian organization. Indeed, a dysfunctional circadian organization is a hallmark of advanced cancer. A cohort of advanced cancer patients undergoing chemotherapy was recruited to investigate whether manipulating exposure to blue light could restore or ameliorate their circadian organization. Methods: Thirty advanced metastatic cancer patients participated in a randomized crossover trial to evaluate whether blue light-blocking night-simulating eyeglasses could ameliorate a disrupted circadian organization better than sham eyeglasses. Circadian organization was evaluated by actigraphy and patients’ self-reports of sleep, fatigue, and quality of life. Kruskal–Wallis tests compared patients’ outcomes in circadian organization with a cohort of non-cancer, disease-free individuals with normal sleep as a negative control, and with advanced cancer patients with disrupted circadian organization as a positive control. Quality-of-life outcomes of the patients were compared with population-based controls (negative controls) and with cohorts of advanced cancer patients (positive controls). Results: Actigraphy measurements, self-reported sleep, fatigue levels, and quality-of-life outcomes of trial participants were similar to those of negative controls with a normal circadian organization, in spite of the trial patients’ concurrent chemotherapy. Night-simulating glasses did not improve circadian organization. The 24-h correlation of day-to-day rhythms of rest and activity was 0.455 for the experimental eyeglasses and 0.476 for the sham eyeglasses ( p = 0.258). Actigraphic and patient-reported outcomes compared favorably to outcomes of positive controls. Conclusion: The circadian organization of patients in this study unexpectedly resembled that of healthy controls and was better than comparison populations with disrupted circadian organization. The study clinic implements chronomodulated chemotherapy and a systematic, supportive integrative treatment protocol. Results suggest a need for further research on interventions for circadian rhythm. Although the study intervention did not benefit the participants, this work highlights the value of supporting circadian time structure in advanced cancer patients.

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To sleep, perchance to live

Cited by 9 publications

References 11 publications

Treatment Effects of Gabapentin for Primary Insomnia

Treatment Effects of Gabapentin for Primary Insomnia

The association of quality of life with potentially remediable disruptions of circadian sleep/activity rhythms in patients with advanced lung cancer

Advanced cancer patients in a randomized clinical trial of night-simulating eyeglasses observed to have a normal 24-h circadian rhythm during chemotherapy

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