To Study the effects of Alcohol on Lipid Profile on Basis of Amount, Type and Duration of Alcohol Consumption

Paul, Kavita; Bairwa, Nariender Kumar; Kazal, Henry L.; Batta, Anil

doi:10.5958/0976-5506.2015.00186.2

Cited by 2 publications

(1 citation statement)

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“…The studies that showed positive changes of lipid metabolism, except for HDL-C, as a consequence of light–moderate drinking of alcohol were inconclusive, especially cross-sectional studies where some outcome had a longer half-life time than those analyzed [115]. On the other hand, the effects of light–moderate drinking of alcohol, including red wine, on triglycerides, LDL, very low density lipoproteins (VLDL), and lipoprotein (a) are unclear and still under debate [116].…”

Section: Putative Mechanisms Of Actionmentioning

confidence: 99%

Red Wine Consumption and Cardiovascular Health

et al. 2019

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Wine is a popular alcoholic beverage that has been consumed for hundreds of years. Benefits from moderate alcohol consumption have been widely supported by the scientific literature and, in this line, red wine intake has been related to a lesser risk for coronary heart disease (CHD). Experimental studies and meta-analyses have mainly attributed this outcome to the presence in red wine of a great variety of polyphenolic compounds such as resveratrol, catechin, epicatechin, quercetin, and anthocyanin. Resveratrol is considered the most effective wine compound with respect to the prevention of CHD because of its antioxidant properties. The mechanisms responsible for its putative cardioprotective effects would include changes in lipid profiles, reduction of insulin resistance, and decrease in oxidative stress of low-density lipoprotein cholesterol (LDL-C). The aim of this review is to summarize the accumulated evidence correlating moderate red wine consumption with prevention of CHD by focusing on the different mechanisms underlying this relationship. Furthermore, the chemistry of wine as well as chemical factors that influence the composition of the bioactive components of red wine are also discussed.

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Section: Putative Mechanisms Of Actionmentioning

confidence: 99%

Red Wine Consumption and Cardiovascular Health

et al. 2019

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Gene-Environment Interaction of Interleukin 10 Gene Polymorphism, rs1800896, with Lifestyle on Cardiovascular Risk in Type 2 Diabetes

Udenze,

Taiwo,

Amadi

et al. 2024

International Journal of Advanced Medical and Health Research

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Background: Gene–environment interactions play a major role in the phenotypic expression of complex disease traits such as those for cardiovascular diseases. Aims: This study aimed to determine the gene–environment interactions that underpin the relationship between interleukin-10 (IL-10) single-nucleotide polymorphism (1082 G/A [rs1800896]) with lifestyle on cardiovascular disease risk in adult Nigerians with type 2 diabetes mellitus (DM). Setting and Design: This case–control study involved patients with type 2 DM with high cardiovascular risk, determined by the Framingham’s classification, and age, sex, and diabetes-duration matched subjects with low and intermediate cardiovascular risks. Subjects and Methods: The genotypes were detected by polymerase chain reaction (PCR) followed by allelic discrimination using the Applied Biosystems 7900HT Fast Real-Time PCR System. One-way analysis of variance and logistic regression were employed for analysis. Odds ratios (ORs) with 95% confidence intervals (CI) were calculated to estimate the risk caused by the polymorphism. P <0.05 was considered significant. Results: The odds for cardiovascular risk decreased progressively in individuals with the GG, GA, and AA genotypes (OR = 0.80, 95% CI = 0.49–1.28, P = 0.345 and OR = 0.46, 95% CI = 0.24–0.88, P = 0.018 for GA and AA genotypes, respectively. A significantly higher proportion of homozygous (AA) individuals were in the low cardiovascular risk group (54.2%, P = 0.018). Compared with the whole study population, individuals with the AA genotype had consistently lower odds for cardiovascular risk in subpopulations like alcohol users (OR = 0.25 [0.11–0.55], P = 0.001), but the odds were higher among smokers (OR = 1.80 [1.14–2.90], P = 0.017) and those with sedentary lifestyles (OR = 2.46, 95% CI = 1.14–5.33, P = 0.024). Conclusions: The homozygous mutant genotype AA of the IL-10 gene 1082 G/A had a protective effect on cardiovascular risk in type 2 DM. However, this protection was absent in those leading a sedentary lifestyle.

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To Study the effects of Alcohol on Lipid Profile on Basis of Amount, Type and Duration of Alcohol Consumption

Cited by 2 publications

References 0 publications

Red Wine Consumption and Cardiovascular Health

Red Wine Consumption and Cardiovascular Health

Gene-Environment Interaction of Interleukin 10 Gene Polymorphism, rs1800896, with Lifestyle on Cardiovascular Risk in Type 2 Diabetes

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