To assess the evidence for homoeopathic medication taken orally in variouspotencies in the treatment for osteoarthritis. Randomized clinical trials as well as animal experiments comparing homoeopathic medicine to placebo or alternative therapies for osteoarthritis (OA) were considered for inclusion. Systematic database searches and manual backtracking through reference list were used to find them. Information on the result, statistical significance, comparison to the placebo or alternative treatment, and side effects were retrieved. The primary studies methodological caliber was assessed until January 2023. In this review, four trials were chosen, and three of them found evidence that the centesimal scale of potency was successful in treating OA. One study had potency on a decimalscale. The majority of the research design substances investigated lacked significant negative effects. The so-called most recent and fresh form of potencies, 50 millesimal (LM scale) has notyet been researched.As conclusion, we were unable to reach any conclusions regarding the proper scale of potency because the data from the published articles was so limited due to the dearth of randomized controlled trials in the field. It is expected that research would increase and focus in particular on the practical applicability of homoeopathic medicine in various potencies