To study the prevalence of thyroid autoimmune antibody in chronic kidney disease patients with hypothyroidism in Eastern Uttar Pradesh

Abstract

Chronic kidney disease (CKD) is defined as the presence of kidney damage. Hypothyroidism is prevalent in patients with CKD, including those on dialysis. The present observational cross-sectional study included 120 patients (70 subjects and 50 controls) who had previously been diagnosed with chronic kidney disease and primary hypothyroidism, as well as those who presented with primary hypothyroidism alone. Serological Estimation of Anti-TPO Antibody, T3, T4 and TSH levels were done as per standard protocol. We enrolled 120 patients, 70 of whom had hypothyroidism in addition to CKD and 50 of whom had hypothyroidism without CKD. Twenty percent of the cases tested positive for anti-TPO antibodies, while 80 % tested negative for anti-TPO antibodies. 71.5 % of positive cases were female, while 28.5 % were male. Among the controls, 74% were positive for anti-TPO antibodies, and 26% were negative. 64.9 % of the positive controls were female, while 35.1 % were male.Our findings indicate that primary hypothyroidism is prevalent in a subgroup of patients with chronic kidney disease. The non-autoimmune mechanism appears to be more prevalent. However, additional multi-centric studies will be necessary to improve the reliability and generalizability of the current study's observations.

Spectrum of Thyroid Dysfunction in Patients with Chronic Kidney Disease in Benin City, Nigeria

“…The fact that most of the CKD patients in this study had no concurrent autoimmune thyroid disease showed that there are other etiological causes of CKD. Other authors reported 20% CKD patients with hypothyroidism were TPO-Abs positive while 80% were negative and 74% of the control subjects were positive for TPO-Abs [ 24 ]. This is also partially consistent with the present study.…”