To Systematically Evaluate and Analyze the Efficacy and Safety of Transcatheter Arterial Chemoembolization (TACE) in the Treatment of Primary Liver Cancer

Abstract

The efficacy and safety of transcatheter arterial chemoembolization (TACE) are systematically evaluated in the treatment of primary liver cancer, which provides a reference for clinical practice and more in-depth research. Cochrane Library, PubMed, EMbase, CBM, CNKI, VIP, and WanFang Data, supplemented by other searches, collected all randomized controlled trials (RCT) comparing TACE combined with TACE alone for HCC. The meta-analysis, after selecting the literature, extracting data, and evaluating the methodological quality of the included studies following the inclusion criteria, was performed using RevMan 5.1 software. There was statistical difference in 3-year survival rate of TACE combined with heat treatment for advanced hepatocellular carcinoma (OR = 1.72,95%CI (1.22,2.41), P = 0.002 , I2 = 0%, and Z = 3.12), total effective rate (OR = 1.91,95%CI (1.31,2.78), P = 0.0008 , I2 = 0%, and Z = 3.37), quality-of-life improvement rate (OR = 2.29,95%CI (1.62,3.23), P < 0.00001 , I2 = 83%, and Z = 3.37), and complication rate (OR = 2.29,95%CI (1.62,3.23), P < 0.00001 , I2 = 83%, and Z = 3.37). Compared with TACE alone, TACE combined with hyperthermia can significantly improve the survival rate and recent efficacy of patients, improve the quality of life, and have a trend to reduce the incidence of toxicity. However, its long-term efficacy and more comprehensive safety need to be verified by more sample and high-quality RCT.

Prognostic efficacy and prognostic factors of TACE plus TKI with ICIs for the treatment of unresectable hepatocellular carcinoma: A retrospective study

“…However, patients with uHCC treated with TACE alone suffered high possibility of tumor recurrence and metastasis, which induces short survival. Also, repeated TACE treatment seriously damages liver function and increases the risk of liver failure ( 17 ). TACE embolizes the liver blood supply, leading to hypoxis tumor microenvironment, releasing a large number of cytokines that promotes revascularization of the residual tumor tissue ( 18 ).…”

Advances in Ferroptosis-Inducing Agents by Targeted Delivery System in Cancer Therapy

“… 140 As a result, tumor therapy has gradually shifted towards multimodal approaches with flexible and adjustable advantages. Numerous studies have demonstrated that compared to single treatment strategies, combining multiple therapies offers distinct advantages in clinical cancer treatment, including efficient synergistic effects, 141 reduced adverse reactions, 142 and addressing drug resistance. 143 In recent years, the development of nano-drug delivery technology has provided a versatile platform for co-loading two or more drugs, opening up promising possibilities for combined tumor therapy.…”

Effect of CT-Guided Microwave Ablation Combined with TACE on Liver Function and Survival of Patients with Primary Liver Cancer

“…As for the MWA method, the lesion can be accurately ablated under the guidance of CT, which is less likely to damage adjacent organs and tissues. However, this method requires a high level of skill, and there is a major risk of liver surface lesion bleeding, so relevant hemostatic measures need to be taken [2,3] . Relevant studies have suggested that these two treatments complement each other when used together.…”