To What Extent Should Artistic and Utilitarian Subjects in School and College Count toward the Degree of A.B.?

Foster, W. Tad

doi:10.1086/434770

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1990

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“…analysis of excreta and tissues demonstrated that aminoglutethimide is extensively metabolised with unchanged drug accounting for only a small proportion of the eliminated radioactivity. A similar finding has been reported for the rat (2) and man (3,4,11,12). A similar pattern was found in the faeces of the mouse.…”

Section: Discussionsupporting

confidence: 89%

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Tissue distribution and elimination of14C-aminoglutethimide in the mouse

Dalrymple

Nicholls

1990

Eur. J. Drug Metab. Pharmacokinet.

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Following oral administration of 14C-aminoglutethimide (Orimeten), male mice excreted 75% and female mice 59% of the administered dose during 24 h. After 72 h, elimination was essentially complete in male mice, whilst recovery from female mice was 74%. As assessed by quantitative assay and whole-body autoradiography, a wide distribution of radioactivity was found with high concentrations of radioactivity occurring only in the bile, gastro-intestinal tract and liver at early times. Residual (72 h) tissue levels of radioactivity were less than 1 microgram equiv. of 14C-aminoglutethimide/g tissue. Metabolite profiles in urine, tissues and faeces showed extensive metabolism of the drug in a pattern similar to that found in the rat.

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Section: Discussionsupporting

confidence: 89%

“…It acts by inhibiting the peripheral aromatisation of androgens to oestrogens (1). The metabolism and excretion of the drug have been studied in the rat (2) and in man (3,4). However, the disposition of amiooglutethimide has not been studied in the mouse, a species often used for anti-cancer drug evaluation.…”

Section: Introductionmentioning

confidence: 99%

Tissue distribution and elimination of14C-aminoglutethimide in the mouse

Dalrymple

Nicholls

1990

Eur. J. Drug Metab. Pharmacokinet.

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To What Extent Should Artistic and Utilitarian Subjects in School and College Count toward the Degree of A.B.?

Cited by 1 publication

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Tissue distribution and elimination of14C-aminoglutethimide in the mouse

Tissue distribution and elimination of14C-aminoglutethimide in the mouse

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