To x-ray or not to x-ray? Screening asymptomatic children for pulmonary TB: a retrospective audit

Gwee, Amanda; Pantazidou, Anastasia; Ritz, Nicole; Tebruegge, Marc; Connell, Tom; Cain, Tim; Curtis, Nigel

doi:10.1136/archdischild-2013-303672

Cited by 22 publications

(10 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, none of these participants had any signs of disease on detailed physical examination or were treated for active TB subsequently. Also, one of our previous studies has shown that chest x-ray changes potentially indicating active TB are rare in asymptomatic children screened after TB contact [43].…”

Section: Discussionmentioning

confidence: 94%

Mycobacterium tuberculosis-specific cytokine biomarkers for the diagnosis of childhood TB in a TB-endemic setting

Sudbury

Otero

Tebruegge

et al. 2019

Journal of Clinical Tuberculosis and Other Mycobacterial Diseas

View full text Add to dashboard Cite

The tuberculin skin test and interferon-gamma release assays have limitations in diagnosing tuberculosis (TB), particularly in children. This study investigated the performance of candidate M. tuberculosis-specific cytokine biomarkers for TB in children in a TB-endemic setting. A total of 237 children with a household contact with smear-positive pulmonary TB were recruited. Importantly, a group of children with illnesses other than TB (sick controls) was included to assess specificity.Median IFN-ɣ, IL-1ra, IL-2, IL-13, IP-10, MIP-1β and TNF-α responses were significantly higher in children with active TB and latent TB infection (LTBI) than in both healthy and sick control children. Three of these cytokines – IL-2, IL-13 and IP-10 – showed better performance characteristics than IFN-ɣ, with IL-2 achieving positive and negative predictive values of 97.7% and 90.7%, respectively. Furthermore, IL-1ra and TNF-α responses differed significantly between active TB and LTBI cases, suggesting that they may be stage-specific biomarkers.Our data indicate that incorporating these biomarkers into future blood-based TB assays could result in substantial performance gains.

show abstract

Section: Discussionmentioning

confidence: 94%

Mycobacterium tuberculosis-specific cytokine biomarkers for the diagnosis of childhood TB in a TB-endemic setting

Sudbury

Otero

Tebruegge

et al. 2019

Journal of Clinical Tuberculosis and Other Mycobacterial Diseas

View full text Add to dashboard Cite

show abstract

“…The researchers of one study conducted in South Africa, observed that children who were diagnosed with TB on CXR seemed to be asymptomatic [27–29]. This shows that symptom based screening would miss some children with primary lung involvement on CXR.…”

Section: Discussionmentioning

confidence: 99%

Contact screening and risk factors for TB among the household contact of children with active TB: a way to find source case and new TB cases

et al. 2019

View full text Add to dashboard Cite

Background Source case investigation, for children with tuberculosis (TB), is conducted to establish the source of infection and to minimize the extent of on-going transmission from infectious persons in the community. The aim of the study was to evaluate the secondary TB cases and to investigate the risk factors in developing TB among the household contacts (HHC) of children with active TB. Methods A prospective cross-sectional study was conducted where 443 caregivers, of 508 children with active TB receiving treatment, were interviewed using a structured questionnaire. Logistic regression analysis was used to examine the risk factors for TB. Results A total of 2397 family members at the median of 5 persons were recorded. Of these, 223 (9.3%) were screened on symptoms basis and 35 (15.7%) of these contacts were diagnosed with TB. Multivariate analysis revealed HHC with TB (OR = 15.288, 95% CI: 5.378–43.457), HHC with smoking (OR = 7.094, 95% CI: 2.128–23.648), and contact of > 18 h with TB individual (OR = 4.681, 95% CI: 1.198–18.294) as statistically significant risk factors of TB among the HHC. Conclusion With the current system of contact screening for TB, only 9.3% of all HHC were screened. The low rates of contacts screened are possibly a repercussion of the passive nature of the program, which mainly depend on distinctive clinical symptoms being experienced by the contacts. Strategies are required to certify adherence with contact screening among children with active TB and to critically consider the factors responsible for TB transmission.

show abstract

“…1 [8,9]. Klassische Manifestationsarten der pulmonalen TB bei Erwachsenen wie Kavernen und Pleuraergüsse werden nur sehr selten beobachtet.…”

Section: Monatsschrift Kinderheilkunde 12 · 2015 1287unclassified

Tuberkulosescreening bei asylsuchenden Kindern und Jugendlichen ‹ 15 Jahren in Deutschland

Ritz

Brinkmann

Feiterna‐Sperling

et al. 2015

Monatsschr Kinderheilkd

View full text Add to dashboard Cite

To x-ray or not to x-ray? Screening asymptomatic children for pulmonary TB: a retrospective audit

Abstract: In contrast to the results from studies in adults, a CXR identified a small but noteworthy number of children with findings suggestive of pulmonary TB in the absence of clinical symptoms.

Cited by 22 publications

References 15 publications

Mycobacterium tuberculosis-specific cytokine biomarkers for the diagnosis of childhood TB in a TB-endemic setting

Mycobacterium tuberculosis-specific cytokine biomarkers for the diagnosis of childhood TB in a TB-endemic setting

Contact screening and risk factors for TB among the household contact of children with active TB: a way to find source case and new TB cases

Tuberkulosescreening bei asylsuchenden Kindern und Jugendlichen ‹ 15 Jahren in Deutschland

Contact Info

Product

Resources

About