Tobacco and alcohol-induced epigenetic changes in oral carcinoma

Ghantous, Yasmine; Schussel, Juliana Lucena; Brait, Mariana

doi:10.1097/cco.0000000000000444

Cited by 46 publications

(43 citation statements)

References 41 publications

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“…Epigenetic processes include DNA methylation, histone posttranslational covalent modifications, changes in chromatin structure, and effects of non-coding RNAs (Arantes et al 2014;Castilho et al 2017). An epigenetic pattern may be modulated by external factors such as diet, alcohol, tobacco, toxins, or pharmaceutical treatment (Ghantous et al 2018). Epigenetic mechanisms are associated with carcinogenesis of numerous cancers (Park et al 2011;Osorio and Castillo 2016) and play an important role in the development of head and neck squamous cell carcinoma (HNSCC).…”

Section: Introductionmentioning

confidence: 99%

Epigenetic Modifications in Head and Neck Cancer

et al. 2019

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Head and neck squamous cell carcinoma (HNSCC) is the sixth most common human malignancy in the world, with high mortality and poor prognosis for patients. Among the risk factors are tobacco and alcohol intake, human papilloma virus, and also genetic and epigenetic modifications. Many studies show that epigenetic events play an important role in HNSCC development and progression, including DNA methylation, chromatin remodeling, histone posttranslational covalent modifications, and effects of non-coding RNA. Epigenetic modifications may influence silencing of tumor suppressor genes by promoter hypermethylation, regulate transcription by microRNAs and changes in chromatin structure, or induce genome instability through hypomethylation. Moreover, getting to better understand aberrant patterns of methylation may provide biomarkers for early detection and diagnosis, while knowledge about target genes of microRNAs may improve the therapy of HNSCC and extend overall survival. The aim of this review is to present recent studies which demonstrate the role of epigenetic regulation in the development of HNSCC.

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Section: Introductionmentioning

confidence: 99%

Epigenetic Modifications in Head and Neck Cancer

et al. 2019

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“…Tobacco, alcohol, and betel nut chewing remain the major culprits with a well-established synergistic effect for the tumorigenesis of OSCC. The highest incidence of OSCC is observed in South 3 Asian countries and regions, such as India, Sri Lanka, and the south-central of China, which are caused by the high rates of cigarette smoking and areca nut use in these areas (5)(6)(7). Although the improvements in early diagnosis and surgical treatment over the past decades, OSCC usually progresses rapidly and presents high mortality rates, especially in patients with an advanced stage, and no targeted therapy is used in clinic for OSCC treatment currently (3,(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Promotion of ubiquitination-dependent survivin destruction contributes to xanthohumol-mediated tumor suppression and overcomes radioresistance in human oral squamous cell carcinoma

Gao

et al. 2020

Preprint

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Background: Overexpression of survivin plays a crucial role in the maintaining unlimited cell growth, apoptosis suppression, and correlates with poor prognosis in human malignancies. Methods: A natural product library was used for natural compound screening through MTS assay. The expression of survivin in oral squamous cell carcinoma (OSCC) and the inhibitory effect of xanthohumol (XN) on OSCC were examined through methods of anchorage-dependent and -independent growth assays, immunoblot, immunofluorescence, immunohistochemical staining, ubiquitination analysis, co-immunoprecipitation assay, CRISPR-Cas9-based gene knockout, and xenograft experiment. Results: Survivin is highly expressed in OSCC cells and patient-derived tissues, and required for OSCC cell growth in vitro and in vivo . With a natural compound screening, we identified that xanthohumol exhibited a significant anti-tumor effect against OSCC cells through inhibiting survivin protein. Xanthohumol suppressed anchorage-dependent and independent cell growth and delayed in vivo tumor development of OSCC cells. Xanthohumol inhibited the Akt-Wee1-CDK1 signaling, which in turn decreased survivin phosphorylation on Thr34, and facilitated E3 ligase Fbxl7-mediated survivin ubiquitination. Xanthohumol alone or in combination with radiation overcame radioresistance in OSCC xenograft tumors. Conclusion: Our findings indicate that targeting survivin for degradation might a promising strategy for OSCC treatment. Keywords: Oral squamous cell carcinoma; Xanthohumol; Ubiquitination; Fbxl7

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“…Although the global incidence of HNSCC is declining, the incidence of HPV related HNSCC, especially oropharyngeal and oral squamous cell carcinoma (OPSCC, OSCC, respectively) is rapidly increasing over the last few decades (11). Recent ndings emphasize the importance of epigenetic changes, such as DNA methylation and alterations including micro RNAs (miRNA), in HNSCC progression and implicate the very role of tobacco and alcohol (12) as well as HPV (13) in those changes.…”

Section: Introductionmentioning

confidence: 99%

DNA Methylome Distinguishes Oropharyngeal and Oral Cancer from Oral Lesions and Healthy Oral Mucosa

Nina

Sabol

Božinović

et al. 2020

Preprint

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Background: There is a strong need to find new, good biomarkers of head and neck squamous cell carcinoma (HNSCC), because of the prognoses and high mortality of patients. The aim of this study was to identify the potential biomarkers in HNSCC that have differences in their DNA methylome and potentially premalignant oral lesions, in comparison to healthy oral mucosa.Methods: In this study 32 oral samples were tested: 9 healthy oral mucosae, 13 HNSCC and 10 potentially premalignant oral lesions for DNA methylation by Infinium MethylationEPIC BeadChip.Results: Our findings showed a panel of genes significantly hypermethylated in their promoters or specific sites in HNSCC samples in comparison to healthy oral samples, which are mainly oncogenes, receptor and transcription factor genes, or genes included in cell cycle, transformation, apoptosis and autophagy. A group of hypomethylated genes in HNSCC, in comparison to healthy oral mucosa, is mainly involved in the host immune response and transcriptional regulation. The results also showed significant differences in gene methylation between HNSCC and potentially premalignant oral lesions, as well as differently methylated genes that discriminate between oral lesions and healthy mucosa.Conclusions: The given methylation panels point to the possibly early diagnostics of HNSCC as well as potentially premalignant oral lesions and its possible implication in clinical practice.

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Tobacco and alcohol-induced epigenetic changes in oral carcinoma

Cited by 46 publications

References 41 publications

Epigenetic Modifications in Head and Neck Cancer

Epigenetic Modifications in Head and Neck Cancer

Promotion of ubiquitination-dependent survivin destruction contributes to xanthohumol-mediated tumor suppression and overcomes radioresistance in human oral squamous cell carcinoma

DNA Methylome Distinguishes Oropharyngeal and Oral Cancer from Oral Lesions and Healthy Oral Mucosa

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