Tobacco and areca nut chewing—Reproductive impairments: An overview

Kumar, Sunil

doi:10.1016/j.reprotox.2012.11.007

Cited by 19 publications

(13 citation statements)

References 38 publications

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“…A couple of review articles on this topic have also concluded that tobacco chewing does lead to adverse pregnancy outcome like LBW, preterm birth and stillbirth [23,24]. A comprehensive review by Ratsch and Bogossian [25] was conducted to identify the association between SLT use and adverse pregnancy outcomes.…”

Section: Discussionmentioning

confidence: 99%

The Human Cost of Tobacco Chewing Among Pregnant Women in India: A Systematic Review and Meta-analysis

Suliankatchi

Sinha

2016

J Obstet Gynecol India

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123 adjusted for smoking with or without adjustment for other factors and duplicate data. Qualitative synthesis was followed by meta-analysis. Attributable burden was estimated using the population attributable fraction method. Main Results Pooled odds ratio was significant for all three outcomes: low birth weight (1.88, 95 % CI 1.38, 2.54), preterm birth (1.39: 1.01, 1.91) and stillbirth (2.85: 1.62, 5.01). We found that 0.87 million low birth weight babies, 0.19 million preterm births and 0.12 million stillbirths occurring annually in India could be attributed to maternal SLT use. Conclusion There was a suggestive evidence of SLT use associated with adverse pregnancy outcomes among women in India. Further studies in this field are required to generate more conclusive evidence.

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Section: Discussionmentioning

confidence: 99%

The Human Cost of Tobacco Chewing Among Pregnant Women in India: A Systematic Review and Meta-analysis

Suliankatchi

Sinha

2016

J Obstet Gynecol India

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“…32 Thus genetic effects attributable to chromosomal damage are possible, as also suggested by several experimental and human studies suggesting potential toxicity of the areca nut on male reproduction. 33 For example, significant elevations in sperm head morphologic abnormalities are seen in pan masala-treated mice, and lower sperm motility and higher frequencies of morphologic abnormalities are reported in human areca nut users versus nonusers. 34 The most credible evidence for the induction of epigenetic changes by paternal exposure to betel quid usage (A catechu nut chewing) is our finding that longer duration of paternal exposure to areca nut usage preconception, and possibly also an earlier age of commencing chewing, were associated with greater risks for the transmission of betel quid-related risks of early occurrence of MetS in humans, overall, and that was seen in families where both parents were free of MetS.…”

Section: Discussionmentioning

confidence: 99%

Longer Duration and Earlier Age of Onset of Paternal Betel Chewing and Smoking Increase Metabolic Syndrome Risk in Human Offspring, Independently, in a Community-Based Screening Program in Taiwan

et al. 2016

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Original research article BACKGROUND: Transgenerational effects of paternal Areca catechu nut chewing on offspring metabolic syndrome (MetS) risk in humans, on obesity and diabetes mellitus experimentally, and of paternal smoking on offspring obesity, are reported, likely attributable to genetic and epigenetic effects previously reported in betel-associated disease. We aimed to determine the effects of paternal smoking, and betel chewing, on the risks of early MetS in human offspring. METHODS:The 13 179 parent-child trios identified from 238 364 Taiwanese aged ≥20 years screened at 2 community-based integrated screening sessions were tested for the effects of paternal smoking, areca nut chewing, and their duration prefatherhood on age of detecting offspring MetS at screen by using a Cox proportional hazards regression model. RESULTS:Offspring MetS risks increased with prefatherhood paternal areca nut usage (adjusted hazard ratio, 1.77; 95% confidence interval [CI], 1.23-2.53) versus nonchewing fathers (adjusted hazard ratio, 3.28; 95% CI, 1.67-6.43) with >10 years paternal betel chewing, 1.62 (95% CI, 0.88-2.96) for 5 to 9 years, and 1.42 (95% CI, 0.80-2.54) for <5 years betel usage prefatherhood (P trend =0.0002), with increased risk (adjusted hazard ratio, 1.95; 95% CI, 1.26-3.04) for paternal areca nut usage from 20 to 29 years of age, versus from >30 years of age (adjusted hazard ratio,1.61; 95% CI, 0.22-11.69). MetS offspring risk for paternal smoking increased dosewise (P trend <0.0001) with earlier age of onset (P trend= 0.0009), independently. CONCLUSIONS:Longer duration of paternal betel quid chewing and smoking, prefatherhood, independently predicted early occurrence of incident MetS in offspring, corroborating previously reported transgenerational effects of these habits, and supporting the need for habit-cessation program provision.longer Duration and earlier age of Onset of Paternal Betel chewing and smoking increase Metabolic syndrome risk in human Offspring, independently, in a community-Based screening Program in taiwan

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“…Furthermore, use of smokeless tobacco during pregnancy had adverse effect on the woman's reproductive physiology and the pregnancy outcome. 2 Altered AMH/MIS levels were reportedly associated with diminished ovarian reserve, 3 thus predisposing reproductive age women to adverse pregnancy outcomes, including miscarriages and/or clinical infertility. Future epidemiological research could use a multicentre cohort-based intervention with face-to-face questionnaire-based interviews for unbiased risk assessment, along with trimester-based biochemical evaluation(s) of maternal serum biomarkers and uterine artery Doppler imaging as possible valuable predictive factors governing pregnancy outcomes, including prediction/prevention of miscarriages in women of ethnically disparate populations.…”

Section: Sirmentioning

confidence: 99%

Risk factors for miscarriage from a prevention perspective: a nationwide follow‐up study

Pandey

Tyagi

2014

BJOG

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Tobacco and areca nut chewing—Reproductive impairments: An overview

Cited by 19 publications

References 38 publications

The Human Cost of Tobacco Chewing Among Pregnant Women in India: A Systematic Review and Meta-analysis

The Human Cost of Tobacco Chewing Among Pregnant Women in India: A Systematic Review and Meta-analysis

Longer Duration and Earlier Age of Onset of Paternal Betel Chewing and Smoking Increase Metabolic Syndrome Risk in Human Offspring, Independently, in a Community-Based Screening Program in Taiwan

Risk factors for miscarriage from a prevention perspective: a nationwide follow‐up study

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