Tobacco and cannabis use in college students are predicted by sex‐dimorphic interactions between <i><scp>MAOA</scp></i> genotype and child abuse

Fite, Paula J.; Brown, Shaquanna; Hossain, Waheeda A.; Manzardo, Ann M.; Butler, Merlin G.; Bortolato, Marco

doi:10.1111/cns.13002

Cited by 26 publications

(23 citation statements)

References 145 publications

(355 reference statements)

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“…The present findings extend our previous report of sexdimorphic influences of G×E interactions in the lifetime use of tobacco (Fite et al, 2018) among college students. Furthermore, these results are consistent with previous evidence indicating sex differences in the interactive influence of these G×E interactions with respect to antisocial conduct (Nikulina et al, 2012;Stogner and Gibson, 2013;Byrd and Manuck, 2014;Harro and Oreland, 2016) and alcohol use (Nilsson et al, 2011).…”

Section: Discussionsupporting

confidence: 90%

“…We recently showed that, among college students, tobacco and cannabis consumption is influenced by the interaction of child maltreatment and the gene MAOA, the X-linked gene encoding for monoamine oxidase A (Fite et al, 2018). In line with our report, Stogner and Gibson (2013) also documented that the interplay of this gene with lifetime stress increases the risk for initiation to alcohol and cannabis use in male adolescents.…”

Section: Introductionsupporting

confidence: 81%

“…A history of maltreatment predisposes female carriers of high-activity alleles (MAOA-H) or male MAOA-L carriers to a greater risk of alcohol use (Nilsson et al, 2011). In alignment with these findings, we found that greater lifetime tobacco use was predicted by the interaction of childhood maltreatment and MAOA-L variants in males and MAOA-H alleles in females (Fite et al, 2018).…”

Section: Introductionsupporting

confidence: 74%

“…DNA extracted and MAOA-uVNTR genotyping were performed as previously described (Fite et al, 2018). All laboratory procedures were carried out by personnel blind to the demographic and psychological characteristics of the subject (other than gender).…”

Section: Maoa Uvntr Variants Genotypingmentioning

confidence: 99%

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Sex-Dimorphic Interactions of MAOA Genotype and Child Maltreatment Predispose College Students to Polysubstance Use

et al. 2020

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Polysubstance use (PSU) is highly prevalent among college students. Recent evidence indicates that PSU is based on gene x environment (G×E) interactions, yet the specific biosocial factors underlying this problem remain elusive. We recently reported that lifetime use of tobacco and cannabis in college students is influenced by the interaction of the Xlinked MAOA (monoamine oxidase A) gene and child maltreatment. Building on these premises, here we evaluated whether the same G×E interaction may also predict PSU in this population. Students of a large Midwestern university (n = 470; 50.9% females) took part in a computer survey for substance use, as well as childhood trauma exposure, using the Child Trauma Questionnaire (CTQ). DNA was extracted from their saliva samples and genotyped for MAOA variable-number of tandem repeat (VNTR) variants. Findings indicated that the highest number of substances were used by male students harboring low-activity MAOA alleles with a history of childhood emotional abuse. In contrast, female homozygous high-activity MAOA carriers with a history of emotional and physical abuse reported consumption of the greatest number of substances. Our results indicate that PSU among college students is influenced by the interaction of MAOA and child maltreatment in a sex-specific fashion. Further studies are warranted to understand the mechanisms of sex differences in the biosocial interplays underlying PSU in this at-risk group.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionsupporting

confidence: 81%

Section: Introductionsupporting

confidence: 74%

Section: Maoa Uvntr Variants Genotypingmentioning

confidence: 99%

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Sex-Dimorphic Interactions of MAOA Genotype and Child Maltreatment Predispose College Students to Polysubstance Use

et al. 2020

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“…The MAO-A gene has a 30-base pair repeat in the promoter region that affects transcriptional efficiency [ 42 ]. The high-activity variant (MAOA-H; 3.5 or 4 repeats) has shown significant association with impulsive personality traits [ 43 ] and tobacco and cannabis use [ 44 ], but other studies have reported conflicting results, with the low-activity variant (MAOA-L; 2, 3, or 5 repeats) associated with disordered gambling [ 45 , 46 ]. However, considering the complexity of IA, to date there is a dearth of studies that have considered possible interactions between genetic vulnerability and the risk provided by the social environment [ 47 ], although recent evidence has highlighted the genetic moderation on the impact of the environment on other disorders and behaviors related to addiction [ 48 ].…”

Section: Introductionmentioning

confidence: 99%

Associations Among Internet Addiction, Genetic Polymorphisms, Family Functioning, and Psychopathological Risk: Cross-Sectional Exploratory Study

et al. 2020

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Background International research has emphasized that youths are at higher risk for the onset of internet addiction (IA), but studies investigating biological, psychological, and social factors associated with this condition are limited. Objective This study aims to investigate the possible association between IA and genetic polymorphisms in monoamine oxidase A (MAO-A), serotonin-transporter (5-HTTPR), dopamine receptor (DRD4), and dopamine transporter (DAT1) genes by considering the role played by the perception of young adults in their family functioning and their depression, anxiety, and avoidant personality problems. Methods In a sample of 104 male and female young adults aged between 19 and 23 years (mean age 21.87, SD 2.29 years) recruited from universities in the central southern part of Italy, we addressed the presence of IA using the Young criteria of the IA test. Moreover, the perception of young adults of their family functioning and their psychopathological symptoms were assessed through the Family Assessment Device (FAD) and the Adult Self-Report, respectively. Results We found no significant association between IA and any genetic polymorphisms, neither among males or females. Young adults with IA reported significantly higher scores in the subscale of FAD affective responsiveness (AR; P=.01) and in depressive problems (P=.02), anxiety problems (P=.009), and avoidant personality problems (P=.003) than those in the control group. Results of mediation analyses showed a mediation role played by depressive symptoms (B=0.99; 95% CI 0.22 to 1.97) and avoidant personality problems (B=1.09; 95% CI 0.32 to 2.05) of young adults on the relationship between the FAD, AR, and IA. Finally, this relationship was moderated by the genotype of the 5-HTTLPR (P<.001), DAT1 (P<.001), and MAO-A (P<.001) genes in young adults. Conclusions This exploratory study supports the recent evidence on the mutual relationship among biological, individual, and social risk factors associated with IA in young adulthood. Our findings may have important clinical implications for the development of prevention and treatment programs.

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Psychological Trauma: Biological and Psychosocial Aspects of Substance Use Disorders

Reichert

Lopes

Silva

et al. 2021

Drugs and Human Behavior

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Tobacco and cannabis use in college students are predicted by sex‐dimorphic interactions between MAOA genotype and child abuse

Abstract: These biosocial underpinnings of tobacco and cannabis use may prove important in the development of novel personalized preventive strategies for substance use disorders in adolescents.

Cited by 26 publications

References 145 publications

Sex-Dimorphic Interactions of MAOA Genotype and Child Maltreatment Predispose College Students to Polysubstance Use

Sex-Dimorphic Interactions of MAOA Genotype and Child Maltreatment Predispose College Students to Polysubstance Use

Associations Among Internet Addiction, Genetic Polymorphisms, Family Functioning, and Psychopathological Risk: Cross-Sectional Exploratory Study

Psychological Trauma: Biological and Psychosocial Aspects of Substance Use Disorders

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