Background:The associations between multiple tobacco products, such as combustible cigarettes (CCs), heated tobacco products (HTPs), and electronic cigarettes (ECs), and mental health status among Korean adolescents have not been extensively studied. Therefore, this study aimed to evaluate the relationship between single or multiple uses of tobacco products and mental health indices among Korean adolescents. Methods: Data from the 2022 Korea Youth Risk Behavior Web-Based Survey were analyzed, and participants included 51,850 individuals aged 13-18 years. Multivariate logistic regression analysis was performed. Results: Of the total participants, 28.8%, 12.7%, and 17.6% reported depressive mood, anxiety, and loneliness, respectively. After adjusting for confounding variables, the CC or EC single users showed a greater likelihood of having depressive mood (odds ratio [OR], 1.65 [95% confidence interval {CI}, 1.41-1.93] or 1.86 [95% CI, 1.44-2.41]), anxiety (OR, 1.38 [95% CI,] or 1.40 [95% CI, 1.01-1.93]), and loneliness (OR, 1.75 [95% CI, or 1.78 [95% CI,) than never users. The dual (i.e., CC and EC) and triple (i.e., CC, EC, and HTP) users were also significantly associated with mental health status, whereas HTP-only users were not. Depressive mood, anxiety, and loneliness were associated with former users. Triple use was associated with a poor mental health status. Conclusion: Considering the poor mental health status and increasing trend of using multiple tobacco products among Korean adolescents, tobacco control policies should monitor the effects of different products.