Tobacco consumption is a reversible risk factor associated with reduced successful treatment outcomes of anti-tuberculosis therapy

Chiang, Yi Chun; Lin, You Meei; Lee, Jen Ai; Lee, Chun-Nin; Chen, Hsiang-Yin

doi:10.1016/j.ijid.2011.10.007

Cited by 23 publications

(46 citation statements)

References 28 publications

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“…Similar to previous studies [21,22], smoking was negatively associated with cure or treatment completion in this study, even after controlling for baseline sociodemographic variables, comorbidities, extent of lung disease, lung cavitation and bacteriology. As expected for the use of standard four-drug short course regimens for drug-susceptible TB, under a fully functioning treatment programme setting that also allowed individualised regimen modification and treatment prolongation, treatment failure was not an expected event.…”

Section: Discussionsupporting

confidence: 86%

Smoking adversely affects treatment response, outcome and relapse in tuberculosis

Leung¹,

Yew

Chan³

et al. 2014

Eur Respir J

144

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The impact of smoking on tuberculosis outcome was evaluated in a territory-wide treatment programme.16 345 consecutive patients undergoing chemotherapy for active tuberculosis in government chest clinics in Hong Kong from 2001 to 2003 were followed up prospectively for 2 years for treatment outcome and subsequently tracked through the territory-wide tuberculosis notification registry for relapse until the end of 2012.Smoking was associated with more extensive lung disease, lung cavitation and positive sputum smear and culture at the baseline. In both current smokers and ex-smokers, sputum smears and cultures were significantly more likely to remain positive after 2 months of treatment. Both categories of smokers were significantly less likely to achieve cure or treatment completion within 2 years. Overall, 16.7% of unsuccessful treatment outcomes were attributable to smoking, with the key contributor being default in current smokers and death in ex-smokers. Among successful treatment completers, there was a clear gradient (hazard ratios of 1.00, 1.33 and 1.63) of relapse risk from never-smokers to ex-smokers and current smokers, with an overall population attributable risk of 19.4% (current smokers: 12.2%; ex-smokers: 7.2%).Smoking adversely affects baseline disease severity, bacteriological response, treatment outcome and relapse in tuberculosis. Smoking cessation likely reduces relapse and secondary transmission. @ERSpublications Smoking adversely affects treatment response in TB. Smoking cessation reduces relapse and secondary transmission.

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Section: Discussionsupporting

confidence: 86%

Smoking adversely affects treatment response, outcome and relapse in tuberculosis

Leung¹,

Yew

Chan³

et al. 2014

Eur Respir J

144

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“…The association of smoking with loss to follow-up in treatment coincides with the findings of another research (20). Perhaps due to smoking itself, the evolution of the disease is exacerbated when combined with the effects of medicines, which drives the patient to feel unwell and to be lost to follow-up.…”

Section: Discussionsupporting

confidence: 84%

“…As smoking is addictive, the patient might find easier quitting TB treatment than quitting smoking. Therefore, in cases where there is an association between smoking and TB, the National TB Control Program should consider working along with other professionals qualified to help in smoking cessation (20).…”

Section: Discussionmentioning

confidence: 99%

Loss to follow-up in tuberculosis treatment and its relationship with patients' knowledge of the disease and other associated factors

Belchior

Mainbourg²,

Ferreira-Gonçalves

2017

Rev. salud pública

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When compared to controls, cases undergoing TB retreatment after loss to follow-up have less knowledge on the disease, which is a sign for the professionals responsible for health education of the need to invest more time and efforts in activities that help the patient understand the disease and its treatment, as well as to have higher levels of adherence. In addition, noncompliance with the follow-up consultation deadline, failure to attend consultations during the current treatment and smoking are also factors that may be influenced by poor knowledge on the disease, which leads to the treatment loss to follow-up.

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“…A nested case-control study from Taiwan that included 302 TB patients, showed that hypertension was associated with a negative outcome of TB treatment. 61 However, multivariate regression did not identify hypertension as an independent risk factor for this outcome.…”

Section: Hypertension and The Outcome Of Tb Treatmentmentioning

confidence: 86%

Tuberculosis and hypertension—a systematic review of the literature

Seegert

Rudolf

Wejse

et al. 2017

International Journal of Infectious Diseases

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Tobacco consumption is a reversible risk factor associated with reduced successful treatment outcomes of anti-tuberculosis therapy

Abstract: As smoking significantly inhibits the effectiveness of TB treatment, the integration of smoking cessation into TB treatment programs is strongly advocated to reduce the dual global burden of smoking and TB.

Cited by 23 publications

References 28 publications

Smoking adversely affects treatment response, outcome and relapse in tuberculosis

Smoking adversely affects treatment response, outcome and relapse in tuberculosis

Loss to follow-up in tuberculosis treatment and its relationship with patients' knowledge of the disease and other associated factors

Tuberculosis and hypertension—a systematic review of the literature

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