Background
Coronary atherosclerotic plaque could go through rapid progression and induce adverse cardiac events. This study aimed to evaluate the impacts of smoking status on clinical outcomes of coronary non-target lesions.
Methods
Consecutive patients with coronary heart disease who underwent two serial coronary angiographies were included. All coronary non-target lesions were recorded at first coronary angiography and analyzed using quantitative coronary angiography at both procedures. Patients were grouped into non-smokers, quitters, and smokers according to their smoking status. Clinical outcomes including rapid lesion progression, lesion re-vascularization, and myocardial infarction were recorded at second coronary angiography. Multivariable Cox regression analysis was used to investigate the association between smoking status and clinical outcomes.
Results
A total of 1255 patients and 1670 lesions were included. Smokers were younger and more likely to be male compared with non-smokers. Increase in percent diameter stenosis was significantly lower (2.7 [0.6, 7.1] %
vs
. 3.5 [0.9, 8.9]%) and 3.4 [1.1, 7.7]%,
P
= 0.020) in quitters than those in smokers and non-smokers. Quitters tended to have a decreased incidence of rapid lesions progression (15.8% [76/482]
vs.
21.6% [74/342] and 20.6% [89/431],
P
= 0.062), lesion re-vascularization (13.1% [63/482]
vs.
15.5% [53/432] and 15.5% [67/431],
P
= 0.448), lesion-related myocardial infarction (0.8% [4/482]
vs.
2.6% [9/342] and 1.4% [6/431],
P
= 0.110) and all-cause myocardial infarction (1.9% [9/482]
vs.
4.1% [14/342] and 2.3% [10/431],
P
= 0.128) compared with smokers and non-smokers. In multivariable analysis, smoking status was not an independent predictor for rapid lesion progression, lesion re-vascularization, and lesion-related myocardial infarction except that a higher risk of all-cause myocardial infarction was observed in smokers than non-smokers (hazards ratio: 3.00, 95% confidence interval: 1.04–8.62,
P
= 0.042).
Conclusion
Smoking cessation mitigates the increase in percent diameter stenosis of coronary non-target lesions, meanwhile, smokers are associated with increased risk for all-cause myocardial infarction compared with non-smokers.