Tobacco craving in smokers with and without schizophrenia

Abstract

We examined tobacco craving and dependence in current smokers (18-65 years) with schizophrenia (N=100) and those without a psychiatric disorder (normal controls, N=100). During the 2-3 hour visit participants completed demographic and smoking related questionnaires and provided a breath CO sample. The Tobacco Craving Questionnaire-Short Form (TCQ-SF) was administered. Immediately after smoking one cigarette, no difference in TCQ-SF total score was Suzanne Lo has nothing to disclose Stephen J. Heishman has nothing to disclose Heather Gallagher Raley has nothing to disclose Katherine Wright has nothing to disclose Heidi J. Wehring has nothing to disclose Eric T. Moolchan is currently an employee of Alkermes Inc. with no conflict of interest to disclose Stephanie Feldman has nothing to disclose Fang Liu has nothing to disclose Robert P. McMahon has nothing to disclose Charles M. Richardson has nothing to disclose Deanna L. Kelly has consulted for Solvay, Janssen and Bristol Myers Squibb Contributors:Suzanne Lo coordinated normal control recruitment and study procedures at NIDA Bayview, and prepared the manuscript Stephen J. Heishman assisted in the development of the protocol, supervised normal control study procedures at NIDA Bayview, and prepared the manuscript Heather Raley coordinated schizophrenia recruitment and study procedures at the MPRC and assisted in manuscript preparation Katherine Wright coordinated schizophrenia recruitment and study procedures at the MPRC Heidi J. Wehring assisted in the study data analysis plan, presentation of the data, and manuscript preparation Eric T. Moolchan assisted in the development of the protocol, assessments and procedures, and assisted in manuscript preparation Stephanie Feldman supervised research activities and regulatory compliance at the MPRC and assisted in manuscript preparation Fang Liu coordinated study data collection, cleaning and management and ran the statistical testing and reporting of results Robert P. McMahon assisted in protocol development and supervised and developed the statistical plan for data analyses. He assisted in manuscript preparation Charles M. Richardson assisted in the protocol development and the recruitment and clinical care of schizophrenia subjects at MPRC. He assisted in manuscript preparation. Deanna L. Kelly designed and wrote the study protocol and assisted in writing the manuscript. She supervised the study procedures, regulatory compliance, and data dissemination plan.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. noted (46.7 ± 19.5 schizophrenia, 42.8 ± 18.2 controls, p=0.15); ...

Illicit drug use in heavy smokers with and without schizophrenia

“…We also observed that schizophrenia participants had higher levels of breath CO 15 minutes post-cigarette, which is consistent with Tidey et al (2005) who reported that schizophrenia patients obtained greater CO boosts from smoking than controls. In the current study, schizophrenia participants also reported higher TCQ-SF scores 15 minutes after a cigarette compared with controls (Lo et al, 2011). Interestingly, this tobacco craving was more robust in the schizophrenia participants with a past history of cocaine use.…”

Predictors of the Perception of Smoking Health Risks in Smokers With or Without Schizophrenia

“…This study was approved by institutional review boards at NIDA, University of Maryland-Baltimore, and the State of Maryland Department of Health and Mental Hygiene. Both inpatients and outpatients were recruited for larger study that was previously reported elsewhere (Kelly et al, 2010; Lo et al, 2011); however, only outpatients are included here. Inpatient participants were excluded because they often have a greater symptom severity and restrictions for tobacco use.…”

Treatment of Tobacco Dependence in People With Mental Health and Addictive Disorders

“…The presence of MHAD may be a vulnerability factor for the initiation and maintenance of smoking as well as for the development of nicotine dependence, which may lead to a more difficult time quitting [12, 13**]. There is also evidence that those with MHADs experience enhanced nicotine withdrawal [14]. The poor long-term cessation rates in adults with MHADs highlight the need for developing better smoking cessation treatments in these populations.…”