Tobacco exposure and susceptibility to tuberculosis: Is there a smoking gun?

Chan, Edward D.; Kinney, William H.; Honda, Jennifer R.; Bishwakarma, Raju; Gangavelli, Avani; Mya, Jenny; Bai, Xiyuan; Ordway, Diane

doi:10.1016/j.tube.2014.08.010

Cited by 33 publications

(30 citation statements)

References 82 publications

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“…Reports in the literature indicate that tobacco use is a significant risk factor for TB, 26,27 and the results of our study support those findings. However, smoking is not currently recognised as a risk factor for TB in Kazakhstan.…”

Section: Discussionsupporting

confidence: 91%

Risks for tuberculosis in Kazakhstan: implications for prevention

Davis

Terlikbayeva

Aifah

et al. 2017

int j tuberc lung dis

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Summary Setting Four regions in Kazakhstan where participants were recruited from June 2012 to May 2014. Objective To examine associations between incarceration history and tobacco, alcohol, and drug consumption, and human immunodeficiency virus (HIV) infection and diabetes mellitus (DM) with TB. Design This matched case-control study included 1600 participants who completed a survey on sociodemographics, history of incarceration, tobacco, alcohol and drug use, and HIV and DM diagnosis. Conditional logistic regression analysis was used to examine associations between a TB diagnosis and risk factors. Results Participants who had ever smoked tobacco (aOR 1.73, 95%CI 1.23–2.43, P ≤ 0.01), ever drank alcohol (aOR 1.41, 95%CI 1.03–1.93, P ≤ 0.05), were HIV-positive (aOR 36.37, 95%CI 2.05–646.13, P ≤ 0.05) or had DM (aOR 13.96, 95%CI 6.37–30.56, P ≤ 0.01) were more likely to have TB. Conclusions The association between TB and tobacco use, alcohol use, HIV and DM in Kazakhstan suggests a need for comprehensive intervention and prevention approaches that also address tobacco and alcohol use, DM and HIV.

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Section: Discussionsupporting

confidence: 91%

Risks for tuberculosis in Kazakhstan: implications for prevention

Davis

Terlikbayeva

Aifah

et al. 2017

int j tuberc lung dis

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“…Thus, the increased infection rate of TB seen among CS‐exposed persons may be due to unaccounted confounders, increased exposure to MTB , intrinsic immunosuppressive effects of CS or any combination of these factors (Fig. ) …”

Section: Limitations Of Epidemiologic Studies Linking Cs Exposure and Tbmentioning

confidence: 99%

“…3). 90 In regards to the effects of CS exposure on the clinical outcome of active TB, it cannot be certain whether smoking increases severity of TB and/or whether CS exposure independently contributes to compromised lung architecture and function. Similarly, whether smoking enhances death by impairing control of TB, decreasing lung function and/or causing other co-morbid conditions that contribute to mortality remains unknown.…”

Section: Direct (Dose)mentioning

confidence: 99%

Epidemiologic link between tuberculosis and cigarette/biomass smoke exposure: Limitations despite the vast literature

et al. 2015

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The geographic overlap between the prevalence of cigarette smoke (CS) exposure and tuberculosis (TB) in the world is striking. In recent years, relatively large number of studies has linked cigarette or biomass fuel smoke exposure and various aspects of TB. Our goals are to summarize the significance of the known published studies, graphically represent reports that quantified the association and discuss their potential limitations. PubMed searches were performed using the key words 'tuberculosis' with 'cigarette', 'tobacco', 'smoke' or 'biomass fuel smoke.' The references of relevant articles were examined for additional pertinent papers. A large number of mostly case-control and cross-sectional studies significantly associate both direct and second-hand smoke exposure with tuberculous infection, active TB, and/or more severe and lethal TB. Fewer link biomass fuel smoke exposure and TB. While a number of studies interpreted the association with multivariate analysis, other confounders are often not accounted for in these analyses. It is also important to emphasize that these retrospective studies can only show an association and not any causal link.We further explored the possibility that even if CS exposure is a risk factor for TB, several mechanisms may be responsible. Numerous studies associate cigarette and biomass smoke exposure with TB but the mechanism(s) remains largely unknown. While the associative link of these two health maladies is well established, more definitive, mechanistic studies are needed to cement the effect of smoke exposure on TB pathogenesis and to utilize this knowledge in empowering public health policies.

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“…Inhalation of such particulates including those from tobacco smoke [8] and their retention in the respiratory system can predispose occupants to many respiratory pathogens. Inhaled PM 2.5 can penetrate deep into lungs and may release nanoparticulates into the blood stream causing inflammation, oxidative damage, vasoconstriction, and cardiometabolic dysfunction [9].…”

Section: Risk Factors For Exposure To Various Types Of Pollutants mentioning

confidence: 99%

“…Apart from the increased risk for lung cancer and other health problems [53], exposure to tobacco smoke can exacerbate chronic obstructive pulmonary disease (COPD) [54] and attacks of asthma and also lower the body's resistance to infectious agents such as tuberculosis [8]. …”

Section: Tobacco Smoke and Air Qualitymentioning

confidence: 99%

Airborne Infectious Agents and Other Pollutants in Automobiles for Domestic Use: Potential Health Impacts and Approaches to Risk Mitigation

Sattar

Wright

Zargar

et al. 2016

Journal of Environmental and Public Health

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The world total of passenger cars is expected to go from the current one billion to >2.5 billion by 2050. Cars for domestic use account for ~74% of the world's yearly production of motorized vehicles. In North America, ~80% of the commuters use their own car with another 5.6% travelling as passengers. With the current life-expectancy of 78.6 years, the average North American spends 4.3 years driving a car! This equates to driving 101 minutes/day with a lifetime driving distance of nearly 1.3 million km inside the confined and often shared space of the car with exposure to a mix of potentially harmful pathogens, allergens, endotoxins, particulates, and volatile organics. Such risks may increase in proportion to the unprecedented upsurge in the numbers of family cars globally. Though new technologies may reduce the levels of air pollution from car exhausts and other sources, they are unlikely to impact our in-car exposure to pathogens. Can commercial in-car air decontamination devices reduce the risk from airborne infections and other pollutants? We lack scientifically rigorous protocols to verify the claims of such devices. Here we discuss the essentials of a customized aerobiology facility and test protocols to assess such devices under field-relevant conditions.

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Tobacco exposure and susceptibility to tuberculosis: Is there a smoking gun?

Cited by 33 publications

References 82 publications

Risks for tuberculosis in Kazakhstan: implications for prevention

Risks for tuberculosis in Kazakhstan: implications for prevention

Epidemiologic link between tuberculosis and cigarette/biomass smoke exposure: Limitations despite the vast literature

Airborne Infectious Agents and Other Pollutants in Automobiles for Domestic Use: Potential Health Impacts and Approaches to Risk Mitigation

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