Tobacco smoke exposure, wheeze, and atopy

Murray, Clare; Woodcock, Ashley; Smillie, F. I.; Cain, G.; Kissen, Patricia; Čustović, Adnan

doi:10.1002/ppul.20019

Cited by 72 publications

(60 citation statements)

References 26 publications

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“…Thirty-one of the 71 studies (44%) were scored as being of moderate or high level (.6) methodological quality. The main reasons for lower NOS scores were lack of an objective measure of smoking since the vast majority relied upon self-reported smoking (only 1 study provided objective data in the form of cotinine levels 17 ), lack of adjustment for confounding factors, and lack of study sample representativeness due to restrictions to children whose parents had an allergic disease.…”

Section: Resultsmentioning

confidence: 99%

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Prenatal and Passive Smoke Exposure and Incidence of Asthma and Wheeze: Systematic Review and Meta-analysis

et al. 2012

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OBJECTIVES: Exposure to passive smoke is a common and avoidable risk factor for wheeze and asthma in children. Substantial growth in the prospective cohort study evidence base provides an opportunity to generate new and more detailed estimates of the magnitude of the effect. A systematic review and meta-analysis was conducted to provide estimates of the prospective effect of smoking by parents or household members on the risk of wheeze and asthma at different stages of childhood. METHODS:We systematically searched Medline, Embase, and conference abstracts to identify cohort studies of the incidence of asthma or wheeze in relation to exposure to prenatal or postnatal maternal, paternal, or household smoking in subjects aged up to 18 years old. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were estimated by using random effects model. RESULTS:We identified 79 prospective studies. Exposure to pre-or postnatal passive smoke exposure was associated with a 30% to 70% increased risk of incident wheezing (strongest effect from postnatal maternal smoking on wheeze in children aged #2 years, OR = 1.70, 95% CI = 1.24-2.35, 4 studies) and a 21% to 85% increase in incident asthma (strongest effect from prenatal maternal smoking on asthma in children aged #2 years, OR = 1.85, 95% CI = 1.35-2.53, 5 studies).CONCLUSIONS: Building upon previous findings, exposure to passive smoking increases the incidence of wheeze and asthma in children and young people by at least 20%. Preventing parental smoking is crucially important to the prevention of asthma. Pediatrics 2012;129:735-744 AUTHORS:

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Section: Resultsmentioning

confidence: 99%

“…19 There was also 1 study that used an objective measure of passive smoke exposure and revealed that children with detectable cord blood levels were not at significantly increased risk of wheeze at age 1 or 3 years or of wheeze at age 3 years in relation to blood cotinine levels at age 1. 17 …”

Section: Figurementioning

confidence: 99%

Prenatal and Passive Smoke Exposure and Incidence of Asthma and Wheeze: Systematic Review and Meta-analysis

et al. 2012

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“…Studies have used cotinine levels obtained from meconium, umbilical cord blood, and maternal hair, urine, or serum to assess prenatal tobacco exposure and have associated increased levels with increased respiratory symptoms and asthma in children. 14,[18][19][20][21] One study performed in adults explored the relationship between cotinine levels and asthma-related hospital admissions; however, this study found that higher hair concentrations of nicotine, but not cotinine, were associated with increased rates of hospitalization. 22 Another study linked urine cotinine levels to hospitalizations for bronchiolitis in infants.…”

Section: Discussionmentioning

confidence: 99%

Cotinine in Children Admitted for Asthma and Readmission

et al. 2014

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WHAT'S KNOWN ON THIS SUBJECT: Serum and salivary cotinine have previously been identified as reliable biomarkers for exposure to tobacco smoke. WHAT THIS STUDY ADDS:We found that detectable serum and salivary cotinine is common among children admitted for asthma and is associated with readmission. This finding may inform clinical care for children at increased risk of asthma morbidity. abstract OBJECTIVE: To explore the relationship between tobacco smoke exposure (reported versus biomarker) and rates of readmission for children hospitalized for asthma. METHODS:We enrolled a prospective cohort of 774 children aged 1 to 16 years admitted for asthma or bronchodilator-responsive wheezing. The primary outcome was at least 1 asthma-or wheeze-related readmission within 1 year. Caregivers reported any tobacco exposure at home, in a secondary residence, or in the car. We measured serum and saliva cotinine levels with mass spectrometry. We used logistic regression to evaluate associations between tobacco exposure and readmissions.RESULTS: A total of 619 children had complete tobacco exposure data; 57% were African American and 76% had Medicaid. Seventeen percent of children were readmitted within 1 year. Tobacco exposure rates were 35.1%, 56.1%, and 79.6% by report, serum, and saliva measures, respectively. Caregiver report of any tobacco exposure was not associated with readmission (adjusted odds ratio: 1.18; 95% confidence interval: 0.79-1.89), but having detectable serum or salivary cotinine was associated with increased odds of readmission (adjusted odds ratio [95% confidence interval]: 1.59 [1.02-2.48] and 2.35 [1.22-4.55], respectively). Among children whose caregivers reported no tobacco exposure, 39.1% had detectable serum cotinine and 69.9% had detectable salivary cotinine. Of the children with reported exposure, 87.6% had detectable serum cotinine and 97.7% had detectable salivary cotinine.CONCLUSIONS: Detectable serum and salivary cotinine levels were common among children admitted for asthma and were associated with readmission, whereas caregiver report of tobacco exposure was not. Pediatrics 2014;133:e355-e362

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“…Most studies investigating the incidence of respiratory symptoms during childhood were either conducted in older children, 20,21 selected high risk populations, 8,9,22 were retrospective, 23 or focused on wheeze only. 7,11,12 Only few studies assessed prospectively incidence of both cough and wheeze in unselected infants (Table 4).…”

Section: Frequency Of Respiratory Symptomsmentioning

confidence: 99%

“…Most authors have studied high-risk children, hospitalized for acute or chronic illness or with a family history of atopy. 8,9 Because of the high costs involved in prospective studies, symptoms have usually been assessed retrospectively, a method hampered by recall bias. In addition, most studies have been limited to wheeze, while incidence of cough has rarely been investigated.…”

Section: Introductionmentioning

confidence: 99%

Prospectively assessed incidence, severity, and determinants of respiratory symptoms in the first year of life

Latzin

Frey

Roiha

et al. 2006

Pediatric Pulmonology

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Summary. Respiratory symptoms are common in infancy. Nevertheless, few prospective birth cohort studies have studied the epidemiology of respiratory symptoms in normal infants. The aim of this study was to prospectively obtain reliable data on incidence, severity, and determinants of common respiratory symptoms (including cough and wheeze) in normal infants and to determine factors associated with these symptoms. In a prospective population-based birth cohort, we assessed respiratory symptoms during the first year of life by weekly phone calls to the mothers. Poisson regression was used to examine the association between symptoms and various risk factors. In the first year of life, respiratory symptoms occurred in 181/195 infants (93%), more severe symptoms in 89 (46%). The average infant had respiratory symptoms for 4 weeks and 90% had symptoms for less than 12 weeks (range 0 to 23). Male sex, higher birth weight, maternal asthma, having older siblings and nursery care were associated with more, maternal hay fever with fewer respiratory symptoms. The association with prenatal maternal smoking decreased with time since birth. This study provides reliable data on the frequency of cough and wheeze during the first year of life in healthy infants; this may help in the interpretation of published hospital and community-based studies. The apparently reduced risk in children of mothers with hayfever but no asthma, and the decreasing effect of prenatal smoke exposure over time illustrate the complexity of respiratory pathology in the first year of life. Pediatr Pulmonol. 2007; 42:41-50.

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Tobacco smoke exposure, wheeze, and atopy

Cited by 72 publications

References 26 publications

Prenatal and Passive Smoke Exposure and Incidence of Asthma and Wheeze: Systematic Review and Meta-analysis

Prenatal and Passive Smoke Exposure and Incidence of Asthma and Wheeze: Systematic Review and Meta-analysis

Cotinine in Children Admitted for Asthma and Readmission

Prospectively assessed incidence, severity, and determinants of respiratory symptoms in the first year of life

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