Tobacco smoking behaviors in bipolar disorder: a comparison of the general population, schizophrenia, and major depression

Díaz, Francisco Javier Rodríguez; James, Danielle; Botts, Sheila; Maw, Lorraine; Susce, Margaret T.; Leon, José de

doi:10.1111/j.1399-5618.2009.00664.x

Cited by 159 publications

(146 citation statements)

References 38 publications

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“…Sibling analysis also control for important environmental factors shared by the siblings. Both smoking and suicidal acts are associated with family dysfunction, other life-style habits, psychological problems and psychiatric diseases not requiring in-patient care [3,14,29,30]. Similar to the present findings, prenatal smoking exposure has recently been associated with increased risks of both attention deficit hyperactivity disorder (ADHD) and low intellectual performance in cohort analyses, but not in analysis within sibling pairs, suggesting underlying familial confounding [31,32].…”

Section: Discussionsupporting

confidence: 76%

“…Maternal smoking has been recognized as one of the most important risk factors for adverse pregnancy outcomes, including placental complications, fetal growth restriction, preterm birth and associated conditions [13]. Women with mental disorders are more often smokers than women without such disorders [14]. Thus, compared with offspring of women without mental disorders, offspring of women with mental disorders are more likely to be prenatally exposed to smoking [15].…”

Section: Introductionmentioning

confidence: 99%

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Maternal smoking during pregnancy and risks of suicidal acts in young offspring

et al. 2011

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Word count (excluding title page, abstract, references and tables): 2,976. 2 AbstractObstetric and neonatal complications have been associated with completed and attempted suicide (suicidal acts) in young offspring. Maternal smoking is one of the most important risk factors for obstetric complications, but the association between prenatal smoking exposure and offspring risk of suicidal acts is unknown.We performed a population-based study of 1 449,333 single births born in Sweden between 1983 and 1996, derived from linked registry data. Maternal smoking and risks of suicidal acts in offspring were estimated using hazard ratios, derived from proportional-hazard models, controlling for potential confounding of parental socio-demographic factors and psychiatric care in first degree relatives. To control for unmeasured familial confounding, a matched case-control analysis of suicidal acts was performed within sibling pairs discordant for prenatal smoking exposure.In the cohort analysis, the adjusted hazard ratio for completed suicide among offspring to women smoking 1-9 cigarettes and at least 10 cigarettes per day were 1.67, 95% confidence interval (CI), 1.29-2.16, and 1.54, 95% CI, 1.12-2.10. For suicidal acts, corresponding hazard ratios were 1.28, 95% CI 1.21-1.35 and 1.48, 95% CI 1.39-1.57, respectively. However, in sibling pairs discordant for suicidal acts and prenatal smoking exposure, we found no evidence that prenatal smoking exposure increased the risk of suicidal acts. We conclude that the association between prenatal smoking exposure and offspring risk of suicidal acts is probably confounded by unmeasured familial factors.Word count: 230

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Maternal smoking during pregnancy and risks of suicidal acts in young offspring

et al. 2011

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“…216 Adults with MDD and BD are 2 to 3 times more likely to be smokers and less likely to successfully quit smoking. [217][218][219][220] Adolescents with MDD and BD are more likely to begin smoking, and begin smoking earlier, than their nondepressed counterparts, 221-224 a significant association because nearly all adult smokers begin smoking as adolescents. There is some evidence that smoking exacerbates the association between CVD and mood disorders.…”

Section: Tobacco Smoking and Substance Usementioning

confidence: 99%

Major Depressive Disorder and Bipolar Disorder Predispose Youth to Accelerated Atherosclerosis and Early Cardiovascular Disease

Goldstein¹,

Carnethon²,

Matthews³

et al. 2015

Circulation

414

290

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Abstract-In the 2011 "Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children andAdolescents," several medical conditions among youth were identified that predispose to accelerated atherosclerosis and early cardiovascular disease (CVD), and risk stratification and management strategies for youth with these conditions were elaborated. Major depressive disorder (MDD) and bipolar disorder (BD) among youth satisfy the criteria set for, and therefore merit inclusion among, Expert Panel tier II moderate-risk conditions. The combined prevalence of MDD and BD among adolescents in the United States is ≈10%, at least 10 times greater than the prevalence of the existing moderate-risk conditions combined. The high prevalence of MDD and BD underscores the importance of positioning these diseases alongside other pediatric diseases previously identified as moderate risk for CVD. The overall objective of this statement is to increase awareness and recognition of MDD and BD among youth as moderate-risk conditions for early CVD. To achieve this objective, the primary specific aims of this statement are to (1) summarize evidence that MDD and BD are tier II moderate-risk conditions associated with accelerated atherosclerosis and early CVD and (2)

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“…This includes patients with schizophrenia [7][8][9][10][11][12][13][14][15], depression [16][17][18][19] and bipolar disorder [20][21][22]. Furthermore, tobacco smoking is the primary cause of preventable diseases and death in the United States [23].…”

Section: Introductionmentioning

confidence: 99%

Genetic Variation of the Mu Opioid Receptor (OPRM1) and Dopamine D2 Receptor (DRD2) is Related to Smoking Differences in Patients with Schizophrenia but not Bipolar Disorder

Hirasawa-Fujita¹,

Bly²,

Ellingrod³

et al. 2014

Clinical Schizophrenia & Related Psychoses

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It is not known why mentally ill persons smoke excessively. Inasmuch as endogenous opioid and dopaminergic systems are involved in smoking reinforcement, it is important to study mu opioid receptor (OPRM1) A118G (rs1799971), dopamine D2 receptor (DRD2) Taq1A (rs1800497) genotypes, and sex differences among patients with schizophrenia or bipolar disorder. Smokers and nonsmokers with schizophrenia (177) and bipolar disorder (113) were recruited and genotyped. They were classified into three groups: current smoker, former smoker, and never smoker by tobacco smoking status self-report. The number of cigarettes smoked per day was used as the major tobacco smoking parameter. In patients with schizophrenia, tobacco smoking prevalence was greater in males than in females as expected, but women had greater daily cigarette consumption (p<0.01). Subjects with schizophrenia who had the OPRM1 *G genotype smoked more cigarettes per day than the AA allele carriers with schizophrenia (p<0.05). DRD2 Taq1A genotype differences had no effect on the number of cigarettes smoked per day. However, female smokers with schizophrenia who were GG homozygous with the DRD2 receptor smoked more than the *A male smokers with schizophrenia (p<0.05). In bipolar patients, there were no OPRM1 and DRD2 Taq1A genotype differences in smoking status. There also were no sex differences for smoking behavior among the bipolar patients. The results of this study indicate that single nucleotide polymorphism (SNP) of the less functional mu opioid receptor increases tobacco smoking in patients with schizophrenia. Alteration of DRD2 receptor function also increased smoking behavior in females with schizophrenia.

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Tobacco smoking behaviors in bipolar disorder: a comparison of the general population, schizophrenia, and major depression

Cited by 159 publications

References 38 publications

Maternal smoking during pregnancy and risks of suicidal acts in young offspring

Maternal smoking during pregnancy and risks of suicidal acts in young offspring

Major Depressive Disorder and Bipolar Disorder Predispose Youth to Accelerated Atherosclerosis and Early Cardiovascular Disease

Genetic Variation of the Mu Opioid Receptor (OPRM1) and Dopamine D2 Receptor (DRD2) is Related to Smoking Differences in Patients with Schizophrenia but not Bipolar Disorder

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