Tobacco smoking is associated with the immune suppressive microenvironment in head and neck squamous cell carcinoma (HNSCC)

Chung, Christine H.; Iglesia, Janis V. de la; Wang, X.; Song, Feifei; Chaudhary, Ritu; Masannat, Jude; Conejo-García, José R.; Hernández-Prera, Juan C.; Slebos, Robbert J.C.

doi:10.1093/annonc/mdz268.035

Cited by 2 publications

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“…In this line, in a meta-analysis, Jiahang et al stated that smokers would benefit from either anti-PD-1/PD-L1 or anti-PD-1/PD-L1 combined with chemotherapy [ 37 ]. However, one report showed that the expression of PD-1 on the lymphocytes of tumor infiltrates was not associated with the smoking status of lung cancer patients [ 38 ], whereas another described that current smokers have significantly lower numbers of CD8+ cytotoxic T cells and PD-L1+ cells than non- and former smokers in head and neck squamous cell carcinoma [ 39 ]. Further analysis will be necessary to establish a definitive conclusion regarding the benefits of smoking and to validate the use of urine as a marker for PD-L1 and PD-1 status in smokers.…”

Section: Discussionmentioning

confidence: 99%

Immunological Status of Bladder Cancer Patients Based on Urine Leukocyte Composition at Radical Cystectomy

et al. 2021

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Background: Bladder cancer (BC) is the ninth most common malignancy worldwide, with high rates of recurrence. The use of urine leukocyte composition at the time of radical cystectomy (RC) as a marker for the study of patients’ immunological status and to predict the recurrence of muscle-invasive bladder cancer (MIBC) has received little attention. Methods: Urine and matched peripheral blood samples were collected from 24 MIBC patients at the time of RC. Leukocyte composition and expression of PD-L1 and PD-1 in each subpopulation were determined by flow cytometry. Results: All MIBC patients had leukocytes in urine. There were different proportions of leukocyte subpopulations. The expression of PD-L1 and PD-1 on each subpopulation differed between patients. Neoadjuvant chemotherapy (NAC), smoking status, and the affectation of lymph nodes influenced urine composition. We observed a link between leukocytes in urine and blood circulation. Recurrent patients without NAC and with no affectation of lymph nodes had a higher proportion of lymphocytes, macrophages, and PD-L1+ neutrophils in urine than non-recurrent patients. Conclusions: Urine leukocyte composition may be a useful tool for analyzing the immunological status of MIBC patients. Urine cellular composition allowed us to identify a new subgroup of LN− patients with a higher risk of recurrence.

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Section: Discussionmentioning

confidence: 99%