Tocolysis after preterm premature rupture of membranes and neonatal outcome: a propensity-score analysis

Abstract

To cite this version:Elsa Lorthe, François Goffinet, Stéphane Marret, Christophe Vayssiere, Cyril Flamant, et al.. Tocolysis after preterm premature rupture of membranes and neonatal outcome: a propensity-score analysis. American Journal of Obstetrics and Gynecology, Elsevier, 2017, 217 (2) Background: There are conflicting results regarding tocolysis in cases of preterm premature

Unit policies regarding tocolysis after preterm premature rupture of membranes: association with latency, neonatal and 2-year outcomes (EPICE cohort)

“…Using unit policies to assess practices makes it possible to minimize indication biases which are of concern in observational studies. We consider this approach to be complementary to previous studies based on an individual-level approach 18,19 . Moreover, to the best of our knowledge, we are the first to report outcomes at two years of corrected age in this specific context.…”

“…Results were reported as hazard ratios (HR) with 95% CI. Known risk factors for shortened latency duration among singleton pregnancies include uterine contractions, cervical changes, oligohydramnios and the occurrence of any complication including infection 18 . We had no exhaustive individual data about the two former and the two latter were considered as intermediate factors.…”

Care of Women Presenting with Suspected Preterm Prelabour Rupture of Membranes from 24+0 Weeks of Gestation

“…More recent publications have shown that compared with no tocolysis, tocolysis is not associated with improved neonatal outcomes. 30,31 Evidence level 1+…”

Ruptura prematura de membranas en nacimientos de pretérmino

“…Su utilización es controvertida. 44 Podría a s o c i a r s e a u n i n c r e m e n t o d e r i e s g o d e corioamnionitis sin mostrar beneficios maternos o neonatales. 1 Por lo tanto, la tocólisis profiláctica solo debería considerarse en los casos en que se requiera postergar el parto 24-48 h para facilitar la maduración pulmonar fetal y el traslado a un centro de mayor complejidad en embarazos < 34 semanas.…”

“…1 Por lo tanto, la tocólisis profiláctica solo debería considerarse en los casos en que se requiera postergar el parto 24-48 h para facilitar la maduración pulmonar fetal y el traslado a un centro de mayor complejidad en embarazos < 34 semanas. [44][45][46] En pacientes con trabajo de parto, la utilización de uteroinhibidores terapéuticos no mostró un aumento de latencia al parto ni mejorar los resultados neonatales. 1…”