Tocolytic Therapy

Haas, David M.; Imperiale, Thomas F.; Kirkpatrick, Page R.; Klein, Robert W.; Zollinger, Terrell W.; Golichowski, Alan M.

doi:10.1097/aog.0b013e318199924a

Cited by 164 publications

(46 citation statements)

References 60 publications

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“…Antepartum, intrapartum and perinatal outcomes were compared between two groups by statistical analysis of data using chi square test and student-t test. [4][5][6][7][8][9][10] and progesterone for prevention of preterm labour in high risk gr. [19][20][21][22][23][24][25][26][27][28][29][30] But there are few studies regarding role of progesterone in threatened PTL.…”

Section: Results and Analysismentioning

confidence: 99%

“…Threatened PTL is diagnosed by the specific criteria mentioned earlier. 6. Patients were screened for exclusion criteria by clinical examination.…”

Section: Materials and Methodologymentioning

confidence: 99%

“…But carry more side effects. [4][5][6][7][8][9][10] Metaanalysis of magnesium sulfate administration failed to support it as a tocolytics agent. Above all, there are insufficient data on long term follow up for reliable conclusion about the effects on the baby of these tocolytic drugs.…”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6][7][8][9] and also been tried for management of threatened PTL. 10 Threatened PTL was diagnosed by: 4 a) Uterine contraction that are painful palpable occur with a frequency of at least once for every 10 minutes') May or may not be associated with cervical changes (Position, consistency, length and dilatation).…”

Section: Introductionmentioning

confidence: 99%

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Comparative Study to Assess the Efficacy Between Intramuscular and Vaginal Micronized Progesterone to Prevent Threatened Premature Labour

Patra¹,

Chattopadhyay²,

Munsi³

et al. 2015

jemds

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Preterm birth remains a major clinical problem. Prematurity is not only a major cause of perinatal mortality but also leads to greater risk for short and long term complications including disability and impediments in growth and mental development. To compare vaginal with intramuscular progesterone administration to prevent preterm labor and to detect the effect of both on the uterine and foetal circulations. STUDY DESIGN: comparative interventional study. POPULATION: 100 pregnant women attending NRSMCH Kolkata, Obstetrics emergency with threatened preterm labour before 34 weeks of gestation. STUDY PERIOD: one year. METHODS: Gestational age was confirmed clinically and by USG of early weeks of gestation. Efficacy and tolerability of progesterone in two routes i.e., intramuscular and vaginal for prevention of threatened preterm labour were compared. OUTCOME: Ante partum, intrapartum and perinatal outcomes were compared between two groups by statistical analysis of data's using chi-square test and student-t test. CONCLUSION: Vaginal progesterone was as effective as intramuscular progesterone in reducing preterm birth with fewer side effects in favor of vaginal route.

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Section: Results and Analysismentioning

confidence: 99%

“…Threatened PTL is diagnosed by the specific criteria mentioned earlier. 6. Patients were screened for exclusion criteria by clinical examination.…”

Section: Materials and Methodologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparative Study to Assess the Efficacy Between Intramuscular and Vaginal Micronized Progesterone to Prevent Threatened Premature Labour

Patra¹,

Chattopadhyay²,

Munsi³

et al. 2015

jemds

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“…Indomethacin is well established as an effective tocolytic agent 1, 2, 3. Indomethacin has a long track record in prevention of spontaneous preterm labor and more recently has been administered to prevent preterm labor during several types of midgestation fetal interventional procedures.…”

Section: Discussionmentioning

confidence: 99%

Indomethacin induced ductus arteriosus closure in midgestation fetus

Beaute

Friedman

2018

Clinical Case Reports

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Association of Intraventricular Hemorrhage and Death With Tocolytic Exposure in Preterm Infants

et al. 2018

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Key Points Question Is tocolysis associated with lower rates of death and intraventricular hemorrhage in preterm infants owing to an effect on the fetal blood-brain barrier? Findings In this cohort study of 1127 mothers who experienced preterm labor and delivered at gestational weeks 24 through 31, the estimated prevalence of death and/or grades III to IV intraventricular hemorrhage was significantly lower in preterm infants with vs without tocolytic exposure (25.3% vs 32.5%). Differences between atosiban and nifedipine exposure for death and/or intraventricular hemorrhage (44.9% vs 51.2%) and for intraventricular hemorrhage (39.1% vs 45.3%) were not significant. Meaning Results for tocolytics are reassuring regarding death and/or intraventricular hemorrhage in preterm infants, but other studies appear to be necessary to compare the effects of atosiban vs nifedipine.

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Tocolytic Therapy

Abstract: Although all current tocolytic agents were superior to no treatment at delaying delivery for both 48 hours and 7 days, prostaglandin inhibitors were superior to the other agents and may be considered the optimal first-line agent before 32 weeks of gestation to delay delivery.

Cited by 164 publications

References 60 publications

Comparative Study to Assess the Efficacy Between Intramuscular and Vaginal Micronized Progesterone to Prevent Threatened Premature Labour

Comparative Study to Assess the Efficacy Between Intramuscular and Vaginal Micronized Progesterone to Prevent Threatened Premature Labour

Indomethacin induced ductus arteriosus closure in midgestation fetus

Association of Intraventricular Hemorrhage and Death With Tocolytic Exposure in Preterm Infants

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