Tocopherol from seeds of Cucurbita pepo against diabetes: Validation by in vivo experiments supported by computational docking

Bharti, Sudhanshu Kumar; Kumar, Amit; Sharma, Neeraj Kumar; Prakash, Om; Jaiswal, S.; Krishnan, Supriya; Gupta, Ashok; Kumar, Awanish

doi:10.1016/j.jfma.2013.08.003

Cited by 62 publications

(31 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, in silico constrained an noconstrained docking studies was performed using FRED and HYBRID programs to understand the mechanism of action with respect to three hypoglycemic proteins, PTP1 B, PPAR-γ, and DPP-IV with respect to 10 botanicals. In nonconstraint docking, all the tocopherols showed interaction in the active sites of the proteins [35]. A significantly reduction in oxidative markers and enhanced cecal and pancreatic characteristics were also observed.…”

Section: Anti-hyperglycemicmentioning

confidence: 90%

Review of Cucurbita pepo (Pumpkin) its Phytochemistry and Pharmacology

Gutierrez¹

2016

Med chem

111

View full text Add to dashboard Cite

Review of Cucurbita pepo (Pumpkin) its Phytochemistry and PharmacologyRosa Martha Perez Gutierrez* AbstractCucurbita pepo, is widely used like food and in folk medicine around of the world. This aims a comprehensive of the pharmacological, chemical constituents, and clinical uses. Also have been identified the medicinally important phyto-constituents belonging mainly to cucurbitosides, multiflorane-type triterpenoids, carotenoids, ent-kauranetype diterpene, and cucurbitaglycosides. Extracts and metabolites of this plant, particularly those from seeds and fruits possess useful pharmacological activities. A survey of the literature shows C. pepo, is mainly known for its improvement in prostatic hiperplasia (BPH), urinary dysfunction and cytotoxic properties, also has also been used extensively as a hypoglycaemic agent. Many pharmacological studies have demonstrated hepatoprotection, inhibit benign prostatic hiperplasia, antioxidant, anticancer, antimicrobial, antiinflamatory, antidiabetic, and antiulcer activities supporting its traditional uses.

show abstract

Section: Anti-hyperglycemicmentioning

confidence: 90%

Review of Cucurbita pepo (Pumpkin) its Phytochemistry and Pharmacology

Gutierrez¹

2016

Med chem

111

View full text Add to dashboard Cite

show abstract

“…Furthermore, the tocotrienol-rich fraction of palm oil improved body glucose utilization and insulin sensitivity of diabetic mice, which was explained by the selective regulation of PPAR target genes. A recent study [143] with poloxamer-407 (PX-407)-induced type 2 diabetic Wistar rats, at which hyperglycemia response was induced due to loss of β-cell sensitivity to glucose, suggested the tocopherol-mediated antihyperglycemic effect of Cucurbita pepo seed oil. Observational studies have suggested the protective effect of alpha-tocopherol against the development of diabetes in humans subjects [144], although no additional benefits have been found with tocopherol supplementation [174].…”

Section: Tocopherols and Tocotrienols In Health Promotionmentioning

confidence: 99%

Tocopherols and Tocotrienols in Common and Emerging Dietary Sources: Occurrence, Applications, and Health Benefits

Shahidi

Camargo

2016

IJMS

331

182

View full text Add to dashboard Cite

Edible oils are the major natural dietary sources of tocopherols and tocotrienols, collectively known as tocols. Plant foods with low lipid content usually have negligible quantities of tocols. However, seeds and other plant food processing by-products may serve as alternative sources of edible oils with considerable contents of tocopherols and tocotrienols. Tocopherols are among the most important lipid-soluble antioxidants in food as well as in human and animal tissues. Tocopherols are found in lipid-rich regions of cells (e.g., mitochondrial membranes), fat depots, and lipoproteins such as low-density lipoprotein cholesterol. Their health benefits may also be explained by regulation of gene expression, signal transduction, and modulation of cell functions. Potential health benefits of tocols include prevention of certain types of cancer, heart disease, and other chronic ailments. Although deficiencies of tocopherol are uncommon, a continuous intake from common and novel dietary sources of tocopherols and tocotrienols is advantageous. Thus, this contribution will focus on the relevant literature on common and emerging edible oils as a source of tocols. Potential application and health effects as well as the impact of new cultivars as sources of edible oils and their processing discards are presented. Future trends and drawbacks are also briefly covered.

show abstract

“…Activity of ESD2 fraction against DPP-IV inhibition suggests a close relationship with the highest tocopherol content in the fraction. Tocopherol isomers isolated from pumpkin seeds have shown a considerable interaction potential with DPP-IV and other proteins known to have diabetic therapeutic potential in HYBRID and FRED docking (Bharti et al, 2013). We assume that the efficacy of ESD2 fraction could be related to the highest α-tocopherol content compared to other fractions (Table 2).…”

Section: Antidiabetic Effectsmentioning

confidence: 99%

Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea

Pozharitskaya¹,

Shikov²,

Laakso

et al. 2015

Journal of Functional Foods

View full text Add to dashboard Cite

Tocopherol from seeds of Cucurbita pepo against diabetes: Validation by in vivo experiments supported by computational docking

Abstract: The results provide pharmacological evidence of CPSE as an antihyperglycemic mediated by the interaction of various botanicals with multiple targets operating in diabetes mellitus (DM).

Cited by 62 publications

References 55 publications

Review of Cucurbita pepo (Pumpkin) its Phytochemistry and Pharmacology

Review of Cucurbita pepo (Pumpkin) its Phytochemistry and Pharmacology

Tocopherols and Tocotrienols in Common and Emerging Dietary Sources: Occurrence, Applications, and Health Benefits

Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea

Contact Info

Product

Resources

About