Tocopherol in Osteoarthritis: A Controlled Pilot Study

Machtey, I; Ouaknine, L

doi:10.1111/j.1532-5415.1978.tb01345.x

Cited by 63 publications

(12 citation statements)

References 13 publications

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“…Our results differ from the study of Machtey and Ouaknine 11. Those authors found a 52% improvement in the group treated with vitamin E compared with 4% in the placebo group.…”

Section: Discussioncontrasting

confidence: 99%

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Vitamin E is ineffective for symptomatic relief of knee osteoarthritis: a six month double blind, randomised, placebo controlled study

Brand

2001

Annals of the Rheumatic Diseases

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Objective-There is a putative role for antioxidant treatment in osteoarthritis (OA) based on animal, epidemiological, and human clinical studies. Vitamin E, a fat soluble vitamin, is one of the major dietary antioxidants. Short term clinical studies using vitamin E in the form of -tocopherol suggested a benefit over placebo of similar dimension to that of diclofenac for relief of OA pain. Methods-A six month, double blind, randomised, placebo controlled study of vitamin E 500 IU/day was carried out. Primary outcome measures were pain, stiVness, and function. Statistical analysis was performed on an intention to treat basis.Results-77 patients were included in the study. Vitamin E showed no benefit over placebo at one month, three months, or six months for any of the outcome measures. The placebo group had higher pain levels (p=0.15) and body mass index (p=0.03) at baseline, and lower pain levels (p=0.02) at completion of the study. Radiological score, exercise score, age, or antioxidant intake at baseline or six months did not diVer between the groups. The reasons for the better performance of the placebo group are uncertain but may relate to the initially higher pain score and subsequent regression to the mean. Conclusions-Vitamin E shows no benefit for the management of symptomatic knee OA. The role of vitamin E in preventing OA progression is currently under investigation. (Ann Rheum Dis 2001;60:946-949) Osteoarthritis (OA) is the most common arthritic condition aVecting an increasingly aging population.

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“…Our results differ from the study of Machtey and Ouaknine 11. Those authors found a 52% improvement in the group treated with vitamin E compared with 4% in the placebo group.…”

Section: Discussioncontrasting

confidence: 99%

“…Several clinical studies have found therapeutic benefits of α-tocopherol in the symptomatic treatment of RA9 10 and OA 11-13. Short term clinical trials with a small number of patients have suggested that vitamin E treatment may be more effective than placebo in relieving pain11 12 and may have similar efficacy to diclofenac 13…”

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confidence: 99%

Vitamin E is ineffective for symptomatic relief of knee osteoarthritis: a six month double blind, randomised, placebo controlled study

Brand

2001

Annals of the Rheumatic Diseases

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“…There are several modalities that may play a role as conservative management for knee osteoarthritis, such as glucosamine, diacerine, and viscoelastic injection. In addition, some researchers have reported molecular targeting therapy, such as vitamin E and glutathione, in the role of the antioxidants to treat knee osteoarthritis (Machtey and Ouaknine 1978; Blankenhorn 1986; Jordan et al 2004). However, some reports have argued against these therapies in the treatment of knee osteoarthritis (Wluka et al 2002; Brand et al 2001), and these treatments remain controversial (Brand et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Can levels of antioxidants in synovial fluid predict the severity of primary knee osteoarthritis: a preliminary study

et al. 2013

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BackgroundLittle is known about differences in amounts of antioxidants or oxidative stress at different stages of knee osteoarthritis. This study investigated the relationship between concentrations of antioxidants, iron and lipid peroxidation in synovial fluid and levels of severity of primary knee osteoarthritis.Materials and methodsFrom 2011 to 2013, 23 patients (mean age, 66.7 ± 7.6 years) with primary knee osteoarthritis were recruited. Patients were divided into 2 groups based on pre-treatment knee society scores (KSS): n = 9, severe KSS ≤46; and n = 14, mild-moderate KSS >46. Synovial fluid was analyzed to determine levels of antioxidants, iron concentrations and lipid peroxidation (thiobarbituric acid reactive substances [TBARs]). Baseline data, including Kellgren- Lawrence radiographic grade, were collected for all patients.ResultsMean KSS was 49.1 ± 10.8. Total mean concentrations of antioxidants were 2.29 ± 1.71 ng/mL vitamin E and 0.47 ± 0.51 nmol/mL glutathione (GSH). Total mean levels of TBARs and iron were 1.20 ± 0.37 nmol/mL and 2.13 ± 0.82 μg/mL, respectively. The mean concentration of vitamin E was inversely related to severity of knee osteoarthritis (mild-moderate > severe, p = 0.006). There were no significant differences between the two groups in terms of GSH (p = 0.90), TBARs (p = 0.84) or iron levels (p = 0.27). There was a significant positive correlation between KSS and vitamin E concentration (r = 0.43, p = 0.04). No significant correlations were shown between KSS and GSH (r = -0.01, p = 0.97), TBARs (r = -0.06, p = 0.81) or iron level (r = 0.28, p = 0.20).ConclusionUsing synovial fluid profiles, vitamin E concentration is an essential prognostic factor in primary knee osteoarthritis and may act as a basis for treatment directions. The concentration of vitamin E decreased as the clinical severity of primary knee osteoarthritis increased.

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“…Two trials concluded that vit E was more efficient than placebo in decreasing pain. In a small 10-day single-blind crossover RCT on mainly spondylosis, 600 mg of vit E per day was superior to placebo as assessed by a patient questionnaire [71], whereas in a 6-week double-blind RCT on OA, 400 IU of α-tocopherylacetate once a day was superior to placebo as assessed by a joined patients' and doctors' global assessment of pain [72]. One trial suggested that vit E was no less efficient than diclofenac in decreasing pain.…”

Section: Resultsmentioning

confidence: 99%

Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence

2006

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The scientific and medical community remains skeptical regarding the efficacy of nutrition for osteoarthritis despite their broad acceptation by patients. In this context, this paper systematically reviews human clinical trials evaluating the effects of nutritional compounds on osteoarthritis. We searched the Medline, Embase, and Biosis databases from their inception to September 2005 using the terms random, double-blind method, trial, study, placebo, and osteoarthritis. We selected all peerreviewed articles reporting the results of randomised human clinical trials (RCTs) in osteoarthritis that investigated the effects of oral interventions based on natural molecules. Studies on glucosamine and chondroitin sulfate were excluded. The quality of the RCTs was assessed with an osteoarthritic-specific standardised set of 12 criteria and a validated instrument. A best-evidence synthesis was used to categorise the scientific evidence behind each nutritional compound as good, moderate, or limited. A summary of the most relevant in vitro and animal studies is used to shed light on the potential mechanisms of action. Inclusion criteria were met by 53 RCTs out of the 2,026 identified studies. Good evidence was found for avocado soybean unsaponifiables. Moderate evidence was found for methylsulfonylmethane and SKI306X, a cocktail of plant extracts. Limited evidence was found for the Chinese plant extract Duhuo Jisheng Wan, cetyl myristoleate, lipids from green-lipped mussels, and plant extracts from Harpagophytum procumbens. Overall, scientific evidence exists for some specific nutritional interventions to provide symptom relief to osteoarthritic patients. It remains to be investigated whether nutritional compounds can have structure-modifying effects.

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Tocopherol in Osteoarthritis: A Controlled Pilot Study

Cited by 63 publications

References 13 publications

Vitamin E is ineffective for symptomatic relief of knee osteoarthritis: a six month double blind, randomised, placebo controlled study

Vitamin E is ineffective for symptomatic relief of knee osteoarthritis: a six month double blind, randomised, placebo controlled study

Can levels of antioxidants in synovial fluid predict the severity of primary knee osteoarthritis: a preliminary study

Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence

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