Tocopherol interrelationships

Hickman, K. C. D.; Harris, Philip L.

doi:10.1002/9780470122518.ch11

Cited by 6 publications

(1 citation statement)

References 116 publications

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“…In the early 1950s, Hickman and Harris first mentioned properties of vitamin E independent from its antioxidative capacity [ 36 ]. Decades later, the research of Azzi and colleagues established several working hypotheses regarding the non-antioxidative properties of α-TOH [ 37 ].…”

Section: Vitamin E Characterizationmentioning

confidence: 99%

Cardiovascular and Metabolic Protection by Vitamin E: A Matter of Treatment Strategy?

Ziegler¹,

Wallert

Lorkowski

et al. 2020

Antioxidants

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Cardiovascular diseases (CVD) cause about 1/3 of global deaths. Therefore, new strategies for the prevention and treatment of cardiovascular events are highly sought-after. Vitamin E is known for significant antioxidative and anti-inflammatory properties, and has been studied in the prevention of CVD, supported by findings that vitamin E deficiency is associated with increased risk of cardiovascular events. However, randomized controlled trials in humans reveal conflicting and ultimately disappointing results regarding the reduction of cardiovascular events with vitamin E supplementation. As we discuss in detail, this outcome is strongly affected by study design, cohort selection, co-morbidities, genetic variations, age, and gender. For effective chronic primary and secondary prevention by vitamin E, oxidative and inflammatory status might not have been sufficiently antagonized. In contrast, acute administration of vitamin E may be more translatable into positive clinical outcomes. In patients with myocardial infarction (MI), which is associated with severe oxidative and inflammatory reactions, decreased plasma levels of vitamin E have been found. The offsetting of this acute vitamin E deficiency via short-term treatment in MI has shown promising results, and, thus, acute medication, rather than chronic supplementation, with vitamin E might revitalize vitamin E therapy and even provide positive clinical outcomes.

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Section: Vitamin E Characterizationmentioning

confidence: 99%

Cardiovascular and Metabolic Protection by Vitamin E: A Matter of Treatment Strategy?

Ziegler¹,

Wallert

Lorkowski

et al. 2020

Antioxidants

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α‐Tocopheryl phosphate – An active lipid mediator?

Zingg

Meydani

Azzi

2010

Molecular Nutrition Food Res

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The vitamin E (alpha-tocopherol, alphaT) derivative, alpha-tocopheryl phosphate (alphaTP), is detectable in small amounts in plasma, tissues, and cultured cells. Studies done in vitro and in vivo suggest that alphaT can become phosphorylated and alphaTP dephosphorylated, suggesting the existence of enzyme(s) with alphaT kinase or alphaTP phosphatase activity, respectively. As a supplement in animal studies, alphaTP can reach plasma concentrations similar to alphaT and only a part is dephosphorylated; thus, alphaTP may act both as pro-vitamin E, but also as phosphorylated form of vitamin E with possibly novel regulatory activities. Many effects of alphaTP have been described: in the test tube alphaTP modulates the activity of several enzymes; in cell culture alphaTP affects proliferation, apoptosis, signal transduction, and gene expression; in animal studies alphaTP prevents atherosclerosis, ischemia/reperfusion injury, and induces hippocampal long-term potentiation. At the molecular level, alphaTP may act as a cofactor for enzymes, as an active lipid mediator similar to other phosphorylated lipids, or indirectly by altering membrane characteristics such as lipid rafts, fluidity, and curvature. In this review, the molecular and cellular activities of alphaTP are examined and the possible functions of alphaTP as a natural compound, cofactor and active lipid mediator involved in signal transduction and gene expression discussed.

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Interrelationships of dietary fat and tocopherols

Mason

Filer

1947

J Americ Oil Chem Soc

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Tocopherol interrelationships

Cited by 6 publications

References 116 publications

Cardiovascular and Metabolic Protection by Vitamin E: A Matter of Treatment Strategy?

Cardiovascular and Metabolic Protection by Vitamin E: A Matter of Treatment Strategy?

α‐Tocopheryl phosphate – An active lipid mediator?

Interrelationships of dietary fat and tocopherols

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