Tocopherols and tocotrienols plasma levels are associated with cognitive impairment

Natural Sources of Tocotrienols: A Note on Absorption

“…Tocotrienols also have similar functions including cellular protection, neuro protection, anti-inflammatory, and antiosteoporotic. In a human study consisting experimental subjects have Alzheimer's disease (AD), cognitive function was tested using valid tools which shows that tocotrienol has delaying effect of AD patients [31]. In other words, serum tocotrienol levels were maintained at high levels when compared to the AD subjects.…”

“…Highest tocotrienols levels were associated with almost 95% lower odds of having AD as compared with lowest tocotrienols subjects. This is possible by tocotrienol mediated prevention of cell death and further neuro degeneration [31].…”

Role of Tocopherols in Treatment of Depression related Alzheimer’sDisease

“…Vitamin E can delay or prevent a clinical diagnosis of Alzheimer disease in elderly persons with mild cognitive impairment. Treatment with antioxidants might theoretically act to prevent propagation of tissue damage and improve both survival and neurological outcome [53]. Administration of vitamin E correlated with cognitive decline and long-time supplementation of vitamin E results in a better cognitive condition and prevents brain oxidative damage [49,50].…”

Nutritional strategies in the management of Alzheimer\'s disease: systematic review and meta-analysis

“…Animal studies posited an ancillary participation in gene expression and in activation and suppression of different enzymatic reactions that may influence cognitive processes; it is deemed necessary for normal neurological functions. Reduced plasma concentrations of different vitamin E forms, altogether, with a simultaneous augmentation in the indexes of vitamin E oxidative/nitrosative damage were found to be related to AD and mild cognitive impairment in senior individuals; this fact insinuates a key role of vitamin E in neurodegeneration (91,92). Although vitamin E deficiencies are exceptional, this depletion manifested neurological and visual disorders including peripheral nerve degeneration, spinocerebellar ataxia, psychomotor abnormalities and retinopathy (93).…”

“…Although vitamin E deficiencies are exceptional, this depletion manifested neurological and visual disorders including peripheral nerve degeneration, spinocerebellar ataxia, psychomotor abnormalities and retinopathy (93). Vitamin E forms also participate in the regulation of membrane-bound enzymes, gene expression, cell signaling processes, cellular proliferation, possess anti-inflammatory properties and contribute to the brain protection against the glutamate-induced neurotoxicity through the modulation of phospholipase A 2 (91). Moreover, it must be noticed that some evidences have reported the involvement of vitamin E in memory, cognition, and emotional functions (94).…”