Tofacitinib citrate for the treatment of refractory, severe chronic actinic dermatitis

Treatment of alopecia universalis with topical Janus kinase inhibitors – a double blind, placebo, and active controlled pilot study

“…Tofacitinib in a dose of 5 mg twice daily orally has been shown in phase II clinical trials to be effective in the treatment of psoriasis and atopic dermatitis . Tofacitinib 2% ointment applied twice daily and ruxolitinib 1% ointment applied twice daily have both been examined in phase I clinical trials in the treatment of psoriasis, and tofacitinib intraocular eye drops have been trialed for the treatment of iritis.…”

“…Ruxolitinib is an oral dual inhibitor of the JAK1 and 2 enzymes that is currently FDA and TGA approved for the Tofacitinib in a dose of 5 mg twice daily orally has been shown in phase II clinical trials to be effective in the treatment of psoriasis and atopic dermatitis. 11,13,15,16 Tofacitinib 2% ointment applied twice daily and ruxolitinib 1% ointment applied…”

Severe chronic actinic dermatitis treated successfully with Thalidomide

“…Recently, oral colostrum-macrophage-activating factor (colostrum-MAF) and biotherapy (Tofacitinib) were also proposed as treatment options in refractory CAD. 1,3,4 The efficacy of thalidomide in CAD was first reported in 2005 in a 37-year-old man with severe recalcitrant CAD resistant to various therapies with clearance of lesions after 5 months of thalidomide. 1 A second case of a 55-year-old man with CAD completely treated within 2 months by thalidomide was reported in 2013.…”

“…Azathioprine, mycophenolate mofetil, cyclosporine, methotrexate, and phototherapy could be used. Recently, oral colostrum‐macrophage‐activating factor (colostrum‐MAF) and biotherapy (Tofacitinib) were also proposed as treatment options in refractory CAD 1,3,4 . The efficacy of thalidomide in CAD was first reported in 2005 in a 37‐year‐old man with severe recalcitrant CAD resistant to various therapies with clearance of lesions after 5 months of thalidomide 1 .…”

Case Report on Chronic Actinic Dermatitis

“…The diagnosis is based on clinical, histopathological and photo biological features. [2][3][4][5][6] Photosensitive eczema in combination with predominantly UVB sensitivity was identified as occurrence of eczema on photo exposed sites. Photo exposed site dermatitis and isolated UVA photosensitivity are also included in the concept of chronic actinic dermatitis in the absence of photoactive drugs, although much less common.…”