Tofacitinib Prevents Radiographic Progression in Rheumatoid Arthritis

Abstract

Tofacitinib, a novel Janus kinase inhibitor, may prevent structural damage in rheumatoid arthritis (RA). In this cohort study, we compared radiographic progression of hand joints between 21 RA patients who took tofacitinb for 18 months in a phase IIb and its extension study and 42 patients who took conventional disease modifying antirheumatic drugs (DMARDs), using simple erosion narrowing score. For tofacitinib group, changes before and after the treatment were also compared. The changes of erosion and sum scores were significantly less in tofacitinib than DMARDs group (for erosion, -0.60 ± 1.83 vs 0.51 ± 1.77, P = 0.038; for sum, -0.50 ± 1.72 vs 1.57 ± 4.13, P = 0.012). Joint space narrowing score (JSN) was also less in tofacitinib group (0.095 ± 0.58 vs 1.06 ± 2.60, P = 0.055). In tofacitinib group, yearly rates of both erosion and JSN were significantly decreased after administration of tofacitinib (For erosion, 0.62 ± 0.93 to -0.14 ± 0.48, P = 0.009; for JSN, 0.47 ± 0.64 to 0.03 ± 0.40, P = 0.032), as was change of sum score (1.09 ± 1.27 to -0.10 ± 0.63, P < 0.001). In conclusion, tofacitinib may prevent structural damage caused by RA.

The Affection of Intimate Relationship Towards Anxiety and Depression

“…They used a survey done in the past in between 2006-2009 on welfare for women. This includes the behaviour of the participants above 15 [11].…”

Tomosynthesis can facilitate accurate measurement of joint space width under the condition of the oblique incidence of X-rays in patients with rheumatoid arthritis

“…Patients with progressive RA exhibit significant functional impairment, with a consequent reduction in quality of life. 1,[22][23][24] Cartilage thinning caused by RA is revealed as JSN in radiographic images. 3,4 The degree of JSN is an indirect index that suggests the degree of cartilage thinning or the progression of RA.…”

“…Cartilage thinning is one effect of this progressive joint damage. 1,2 Although cartilage thinning is revealed as joint space narrowing (JSN) in diagnostic imaging, the first radiographic sign of RA in relation to joint space width (JSW) is widening. JSW can therefore be an indirect index used to assess the degree of cartilage damage and hence the progression of RA.…”