Tofranil (Imipramine) in the Treatment of Depressive States

Keup, W; Apolito, A; Olinger, Leon; Schwartz, Milton M.; Yachnes, Eleanor

doi:10.1097/00005053-196002000-00007

Cited by 9 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 1958, when Kuhn first reported on the antidepressant effects of imipramine, he noted that patients with 'endogenous depressions' showed a better clinical response than other depressive patients, including those with 'reactive depressions'. Since 1958 there have been numerous published reports confirming Kuhn's initial observation (Blair, 1960;Delay & Deniker, 1959;Friedman et al, 1961;Keup et al, 1960;Kiloh & Garside, 1963). There have also been instances in which investigators have failed to replicate Kuhn's findings (Abraham et al, 1963;Fleminger & Groden, 1962;Lemene, 1959;Richmond & Roberts, 1964;Spear et al, 1964).…”

mentioning

confidence: 93%

The endogenous—neurotic distinction as a predictor of response to antidepressant drugs

1976

View full text Add to dashboard Cite

SynopsisAn inverse factor analysis of 880 depressed inpatients on 33 endogenous–neurotic variables yielded four patient types. Type 3 resembled the endogenous depressions and Type 2 the neurotic depressions. Type 3 patients responded well to both imipramine and chlorpromazine and did poorly on a placebo. Type 2 patients showed the greatest overall improvement at three weeks irrespective of treatment received, including a placebo.

show abstract

mentioning

confidence: 93%

The endogenous—neurotic distinction as a predictor of response to antidepressant drugs

1976

View full text Add to dashboard Cite

show abstract

“…Sargant (1967) has suggested that members of the imipramine group are useful in endogenous and MAOT groups in neurotic depression. These observations have been confirmed by many (Ayd, 1959;Blair, 1960;Friedman, DeMowbray and Hamilton, 1961;Greenblatt, Grosser and Weschsler, 1962;Keup et al, 1960;Kiloh, Ball andGarsidè, 1962, Lehmann, 1965) while others have failed to confirm Kuhn's original finding (Abraham et al, 1976;Fleminger and Görden, 1962, Rees et al, 1961, and Spear et al, 1964. The diagnostic criteria of endogenous depression have not been spelled out in most instances and thus predictive value is lost.…”

Section: Endogenous-neuroticmentioning

confidence: 94%

Clinical Prediction of Antidepressant Response

Ananth¹

1978

Int Pharmacopsychiatry

View full text Add to dashboard Cite

Depression is not a unitary disease and not all cases of depression can be treated alike. Therefore, predictors of antidepressant response to different drugs need to be identified. Premorbid personality, age and sex and family history are useful in prediction. As an example, only females respond to the addition of triiodothyronine to the antidepressant therapy. Endogenous depressions respond favourably to antidepressants, so also do psychotic depressions. On the other hand, delusional depressions do not respond to antidepressants. While atypical depressions are best treated with MAOI, motor retardation improves with imipramine and obsessive symptoms with chlorimipramine. In addition to clinical variables, biochemical and statistical approaches have also yielded significant results in prediction.

show abstract

A Criticism of Drug Therapy in Psychiatry

Liberman¹

1961

Arch Gen Psychiatry

View full text Add to dashboard Cite

Tofranil (Imipramine) in the Treatment of Depressive States

Cited by 9 publications

References 0 publications

The endogenous—neurotic distinction as a predictor of response to antidepressant drugs

The endogenous—neurotic distinction as a predictor of response to antidepressant drugs

Clinical Prediction of Antidepressant Response

A Criticism of Drug Therapy in Psychiatry

Contact Info

Product

Resources

About