Toggling Between Blue- and Red-Emitting Fluorescent Silver Nanoclusters

Anand, Uttam; Ghosh, Subhadip; Mukherjee, Saptarshi

doi:10.1021/jz301733y

Cited by 77 publications

(112 citation statements)

References 30 publications

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“…[1][2][3] The ultra small size regime of these NCs (<1 nm, comparable to the Fermi wavelength of conduction electrons) results in its quantum like behaviour giving rise to discrete electronic transitions and size dependent luminescence, in contrast to metal nanoparticles which are larger in size. 3,4 Further these NCs are less toxic than quantum dots which closely resemble them in terms of quantum phenomenon. 4,5 Several synthetic strategies have been proposed for these NCs using various selforganised assemblies like, protein, 3 DNA, 6 peptides, 7 polymer, 8 dendrimer 9 and thiols 1,10 as templates.…”

Section: Introductionmentioning

confidence: 99%

“…As the synthetic protocol of NCs mentioned herein is biocompatible and non-toxic hence, it can be efficiently applied for cell imaging, optical sensing and various bio-medical investigations. 3 During the past decade researchers mainly focused on the synthesis of Gold and Silver NCs and developed multiple interdisciplinary applications using them as the luminescent probes. 11 On the contrary, Copper NCs (CuNCs) are still rarely explored due to the limitations involved in their synthesis in controlling ultra fine size and their propensity to undergo oxidation.…”

Section: Introductionmentioning

confidence: 99%

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Luminescent Copper Nanoclusters as a Specific Cell-Imaging Probe and a Selective Metal Ion Sensor

et al. 2015

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Copper nanoclusters (CuNCs) exhibit a high tendency to undergo oxidation particularly at the subnanometer size regime. In the light of overcoming this bottleneck, we have been successful in developing tripeptide (glutathione, GSH) templated CuNCs which show high biocompatibility and stability, in spite of being ultrafine in size. These blue-emitting CuNCs possess very promising optical features such as significant quantum yield (QY) and excellent photostability. Our cell-imaging studies reveal that the CuNCs localize primarily in nuclear membranes of the different cancerous (Hela, MDAMB-231, and A549) cells, and the cell viability assay conclusively established their nontoxic nature. Apart from their biological significances, these CuNCs also illustrate their ability to serve as a metal ion sensor, selectively detecting Fe 3+ ions in solution at the nanomolar concentration regime. This unique luminescent property of the NCs will enable them to serve as label-free and versatile probes having several biological and analytical applications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Luminescent Copper Nanoclusters as a Specific Cell-Imaging Probe and a Selective Metal Ion Sensor

et al. 2015

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“…To the authors' knowledge, no Cu-NCs based fluorescent probes have been reported for hypochlorite until now. In addition, although various synthetic methods have been used for the preparation of metal NCs, it remains a great challenge to increase the fluorescent properties of these NCs [16].…”

Section: Introductionmentioning

confidence: 99%

Copper nanocluster-based fluorescent probe for hypochlorite

2015

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Copper nanoclusters (Cu-NCs) were fabricated by chemical reduction of Cu(II) ions using formaldehyde as the reductant and poly(vinyl pyrrolidone) as the protecting agent. The resulting Cu-NCs were characterized by TEM, FT-IR, UV-vis and XPS and fluorescence spectroscopy. The CuNCs display a luminescence quantum yield of about 13 %, and the emission peaks shift from 398 to 457 nm on increasing the excitation wavelength from 310 to 390 nm. The Cu-NCs possess a storage stability of at least 2 months and are stable in the presence of high concentrations of salt. Their fluorescence is strongly quenched by hypochlorite, while other common cations, anions and hydrogen peroxide have minor (or no) effects on fluorescence. On this basis, a fluorometric hypochlorite assay was developed that has a 0.1 μM detection limit and a linear range that extends from 1 to 30 μM. The method was successfully used to the determination of hypochlorite in local tap water samples, and the results agreed well with those obtained by a colorimetric method.

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“…12−37 However, very few demonstrations of the synthesis of green and blue light-emitting AgNCs are available because of their ultrasmall size in comparison to that of the red lightemitting AgNCs. 5,17,18,20,29,38,39 Though substantial progress has been achieved in the preparation of AgNCs, several synthetic issues remain in the reported methods, such as larger templates, expensive chemicals, toxic reducing agents, and organic solvents, which may limit the biological applications. Therefore, it would be of great interest to develop a facile and convenient procedure for synthesizing stable, highly luminescent, and biocompatible AgNCs.…”

Section: ■ Introductionmentioning

confidence: 99%

Sodium Cholate-Templated Blue Light-Emitting Ag Subnanoclusters: In Vivo Toxicity and Imaging in Zebrafish Embryos

Chandirasekar

Chandrasekaran

Muthukumarasamyvel

et al. 2015

ACS Appl. Mater. Interfaces

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We report a novel green chemical approach for the synthesis of blue light-emitting and water-soluble Ag subnanoclusters, using sodium cholate (NaC) as a template at a concentration higher than the critical micelle concentration (CMC) at room temperature. However, under photochemical irradiation, small anisotropic and spherically shaped Ag nanoparticles (3-11 nm) were obtained upon changing the concentration of NaC from below to above the CMC. The matrix-assisted laser desorption ionization time-of-flight and electrospray ionization mass spectra showed that the cluster sample was composed of Ag4 and Ag6. The optical properties of the clusters were studied by UV-visible and luminescence spectroscopy. The lifetime of the synthesized fluorescent Ag nanoclusters (AgNCs) was measured using a time-correlated single-photon counting technique. High-resolution transmission electron microscopy was used to assess the size of clusters and nanoparticles. A protocol for transferring nanoclusters to organic solvents is also described. Toxicity and bioimaging studies of NaC templated AgNCs were conducted using developmental stage zebrafish embryos. From the survival and hatching experiment, no significant toxic effect was observed at AgNC concentrations of up to 200 μL/mL, and the NC-stained embryos exhibited blue fluorescence with high intensity for a long period of time, which shows that AgNCs are more stable in living system.

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Toggling Between Blue- and Red-Emitting Fluorescent Silver Nanoclusters

Cited by 77 publications

References 30 publications

Luminescent Copper Nanoclusters as a Specific Cell-Imaging Probe and a Selective Metal Ion Sensor

Luminescent Copper Nanoclusters as a Specific Cell-Imaging Probe and a Selective Metal Ion Sensor

Copper nanocluster-based fluorescent probe for hypochlorite

Sodium Cholate-Templated Blue Light-Emitting Ag Subnanoclusters: In Vivo Toxicity and Imaging in Zebrafish Embryos

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