Tokuhashi score and other prognostic factors in 260 patients with surgery for vertebral metastases

Abstract

Our cohort study supports the validity and reproducibility of the Tokuhashi score. Our finding that shorter time to metastasis diagnosis and age ≥ 70 years were also significantly associated with survival in our population invites further efforts to improve and update the Tokuhashi score.

Prognostic Factors of Surgical Complications and Overall Survival of Patients with Metastatic Spinal Tumor

“…Age, preoperative motor disorders, Frankel grade categories, KPS, type of the primary tumor, presence of internal metastasis, and number of metastases in the vertebral body were found to have a significant negative effect on OS. Eap et al [18] found increased age to be a bad prognostic factor for survival, which our results also confirm. Preoperative motor disorders were previously reported to be a bad prognostic factor for survival [19,20].…”

Treatment, complications, and outcomes of metastatic disease of the spine: from Patchell to PROMIS

“…Mean survival for spinal metastases is dependent on tumor histology and, depending on the study cited, may range from 51 months for myeloma to 26 months for thyroid cancer to less than 6 months for lung, stomach, esophagus, or pancreatic cancer (57,58). A number of studies (57)(58)(59)(60)(61)(62)(63) have attempted to identify prognosticators or use scoring systems to predict post-treatment survival in these patients. A systematic review and meta-analysis by Luksanapruksa et al (64) identified seventeen prognosticators of poor outcomes across 43 studies, including factors such as age >65 years old, multiple metastases (bone or visceral), ≥3 involved vertebrae, non-ambulatory status before treatment, KPS <70, male gender, and increasing time from cancer diagnosis to surgery.…”

Analysis of Four Scoring Systems for the Prognosis of Patients with Metastasis of the Vertebral Column

“…Eap at al. [26] reported the reproducibility and usefulness of the system in a 260-patient population and found a weighted Cohen k coefficient of 0.41 (95% CI, 0.33-0.50). Our results confirm the findings in the literature.…”

“…The scoring systems have their own errors and pitfalls, [7,11,25,31,32] but they are widely accepted in clinical practice. [7,11,24,26,27,[33][34][35][36] The results are shown in Table 11.…”